Full-blown graft-versus-host disease presenting with skin manifestations, jaundice and diarrhoea

2003 ◽  
Vol 15 (5) ◽  
pp. 565-569
Author(s):  
Stefan Sleijfer ◽  
Aukje Kaptein ◽  
Michel I.M. Versteegh ◽  
Vincent Noordhoek Hegt ◽  
Dyon G.C.T.M. Snels ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Skin Manifestations

Full-blown graft-versus-host disease presenting with skin manifestations, jaundice and diarrhoea

2003 ◽  
Vol 15 (5) ◽  
pp. 565-569 ◽  
Author(s):  
Stefan Sleijfer ◽  
Aukje Kaptein ◽  
Michel IM Versteegh ◽  
Vincent Noordhoek Hegt ◽  
Dyon GCTM Snels ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Skin Manifestations

Principles of Non-Pharmacological Correction of Skin Toxicity and Skin Manifestations of a Chronic «Graft Versus Host» Disease

2019 ◽  
Vol 6 (2) ◽  
pp. 87-93
Author(s):  
Elena A. Shuginina ◽  
Olga I. Rassokhina
Keyword(s):  
Graft Versus Host Disease ◽  
Contemporary Literature ◽  
Skin Toxicity ◽  
New Approach ◽  
Host Disease ◽  
Graft Versus Host ◽  
Skin Manifestations ◽  
Pharmacological Correction

This publication focuses on skin toxicity and skin manifestations of a chronic graft versus host disease (chGVHD). The article provides analysis of contemporary literature on these pathologies, presents new approach to preventing its development and also introduces pathogenetically determined patterns of non-drug correction of skin manifestations.

scholarly journals Nedocromil sodium ameliorates skin manifestations in a murine model of chronic graft-versus-host disease

1997 ◽  
Vol 19 (8) ◽  
pp. 823-828 ◽  
Author(s):  
F Levi-Schaffer ◽  
MA Goldenhersh ◽  
V Segal ◽  
A Nagler
Keyword(s):  
Graft Versus Host Disease ◽  
Murine Model ◽  
Nedocromil Sodium ◽  
Host Disease ◽  
Graft Versus Host ◽  
Skin Manifestations

scholarly journals Type 2 innate lymphoid cells from Id1 transgenic mice alleviate skin manifestations of graft-versus-host disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Anand Srinivasan ◽  
Sandra Bajana ◽  
Aneta Pankow ◽  
Carrie Yuen ◽  
Rikin K. Shah ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Graft Versus Host Disease ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Host Disease ◽  
Graft Versus Host ◽  
Skin Manifestations ◽  
Cell Based Therapy ◽  
E Protein ◽  
Genetically Engineered Mice

Abstract Background Acute graft-versus-host disease (aGVHD) is one of the most common causes of morbidity for patients undergoing allogeneic stem cell transplantation. There is preliminary evidence that activated Group 2 innate lymphoid cells (ILC2s) from wild type (WT) mice reduces the lethality of aGVHD and is effective in treating lower gastrointestinal (GI) tract manifestations of aGVHD. This raises the prospect that ILC2s may be used for cell-based therapy of aGVHD but vigorous investigation is necessary to assess their impacts on different aspects of aGVHD. Genetically engineered mice which either express Id1 protein (Id1tg/tg), an inhibitor of E protein transcription factors or have E protein genes knocked out (dKO) in the thymus produce massive numbers of ILC2s, thus allowing extensive evaluation of ILC2s. We investigated whether these ILC2s have protective effects in aGVHD as WT ILC2s do using an established mouse model of aGVHD. Results bone marrow transplant was performed by irradiating BALB/c strain of recipient mice and transplanting with bone marrow and T cells from the MHC-disparate C57BL/6 strain. We isolated ILC2s from Id1tg/tg and dKO mice and co-transplanted them to study their effects. Our results confirm that activated ILC2s have a protective role in aGVHD, but the effects varied depending on the origin of ILC2s. Co-transplantation of ILC2s from Id1tg/tg mice were beneficial in aGVHD and are especially helpful in ameliorating the skin manifestations of aGVHD. However, ILC2s from dKO mice were less effective at the protection and behaved differently depending on if the cells were isolated from dKO mice were pre-treated with IL-25 in vivo. Conclusion These findings support the notion that thymus-derived ILC2s from Id1tg/tg mice are protective against aGVHD, with a significant improvement of skin lesions and they behave differently from dKO mice in the setting of aGVHD.

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