Metformin versus Ethinyl Estradiol-Cyproterone Acetate in the Treatment of Nonobese Women with Polycystic Ovary Syndrome: A Randomized Study

2003 ◽  
Vol 58 (6) ◽  
pp. 390-391 ◽  
Author(s):  
Laure Morin-Papunen ◽  
Ilkka Vauhkonen ◽  
Riitta Koivunen ◽  
Aimo Ruokonen ◽  
Hannu Martikainen ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cyproterone Acetate ◽  
Ethinyl Estradiol ◽  
Polycystic Ovary ◽  
Randomized Study ◽  
Ovary Syndrome

scholarly journals Effects of Oral Contraceptives and Metformin on The Concentrations of Anti-Müllerian Hormone in Women with Polycystic Ovary Syndrome

2020 ◽  
Author(s):  
Liping Wang ◽  
Ke Hua ◽  
Wenwei Cai ◽  
Weiping Fu ◽  
Hongxia Zhang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Cyproterone Acetate ◽  
Ethinyl Estradiol ◽  
Polycystic Ovary ◽  
Metformin Treatment ◽  
Metabolic Disturbances ◽  
Ovary Syndrome ◽  
Metformin Group ◽  
Before And After

Abstract Background: Whether treatment with oral contraceptives (OC) and metformin can reduce anti-Müllerian hormone (AMH) levels in PCOS remains controversial. This study aims to investigate the effects of OC and metformin on serum AMH concentrations in women with polycystic ovary syndrome (PCOS). Methods: This prospective study included 120 women with PCOS. Patients were treated with OC (35 μg of ethinyl estradiol plus 2 mg of cyproterone acetate), metformin, or OC plus metformin for 3 months according to their different endocrine/metabolic disturbances. Forty-eight patients with hyperandrogenism (HA) were treated with OC, 32 patients with insulin resistance (IR) were treated with metformin, and 40 patients with HA and IR were treated with a combination of OC and metformin. Serum AMH levels were compared before and after treatment within each group.Results: AMH levels decreased significantly in both OC groups (from 12.54 ± 5.59 ng/mL before treatment to 9.03 ± 4.49 ng/mL after treatment, P < 0.01) as well as in the OC + metformin group (from 10.62 ± 4.57 ng/mL to 7.74 ± 3.19 ng/mL, P < 0.01). However, AMH concentrations remained unchanged in the metformin group, although insulin sensitivity was improved. Conclusion: Treatment with OC alone or OC plus metformin led to a significant reduction of serum AMH in PCOS patients with HA, while metformin treatment alone did not affect AMH levels in patients with IR.

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