scholarly journals Liver Transplantation for Hepatocellular Carcinoma: Need for a New Patient Selection Strategy

2004 ◽  
Vol 240 (5) ◽  
pp. 923-924 ◽  
Author(s):  
Timothy M. Pawlik ◽  
Eddie K. Abdalla ◽  
Jean-Nicolas Vauthey
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Selection Strategy

Patient Selection by Tumor Markers in Liver Transplantation for Advanced Hepatocellular Carcinoma

2018 ◽  
Vol 24 (9) ◽  
pp. 1243-1251 ◽  
Author(s):  
Hae Won Lee ◽  
Gi-Won Song ◽  
Sung-Gyu Lee ◽  
Jong Man Kim ◽  
Jae-Won Joh ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Markers ◽  
Patient Selection ◽  
Advanced Hepatocellular Carcinoma

TACE as Bridging to Liver Transplantation in Patients with Hepatocellular Carcinoma: Are Milan Criteria Suitable for Patient Selection?

2012 ◽  
Vol 94 (10S) ◽  
pp. 638
Author(s):  
G. Otto ◽  
M. Heise ◽  
M. Hoppe-Lotichius ◽  
T. Hansen ◽  
M. Woerns ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Milan Criteria

The Outcome of Liver Transplantation in Patients With Hepatocellular Carcinoma in the United States Between 1988 and 2001: 5-Year Survival Has Improved Significantly With Time

2003 ◽  
Vol 21 (23) ◽  
pp. 4329-4335 ◽  
Author(s):  
Hwan Y. Yoo ◽  
Cary H. Patt ◽  
Jean-Francois Geschwind ◽  
Paul J. Thuluvath
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Patient Survival ◽  
The United States ◽  
Control Group ◽  
Cox Regression Analysis ◽  
The Past ◽  
Kaplan Meier ◽  
Improvement In Survival

Purpose: We hypothesized that the outcome of liver transplantation in patients with hepatocellular carcinoma (HCC) has improved over the past decade because of the application of published criteria for patient selection. In this study, we compared the outcome of liver transplantation in patients with and without HCC at different time periods using the United Network for Organ Sharing data. Patients and Methods: We excluded children, patients with multiple organ transplantation or retransplantation, and those with incomplete survival data. The study period was arbitrarily divided into three time intervals: 1987 to 1991, 1992 to 1996, and 1997 to 2001. Results: During the study period, 985 patients with HCC (HCC group), and 33,339 without HCC underwent liver transplantation (control group). Kaplan-Meier patient and graft survivals were significantly lower for the HCC group compared with the control group. Cox regression analysis (after adjusting for other confounding variables) confirmed a lower patient survival in the HCC group (1-year survival, 77.0% v 86.7%; hazard ratio [HR], 1.7; 95% CI, 1.5 to 2.0; P < .0001) compared with the control group (5-year survival, 48.2% v 74.7%; HR, 2.2; 95% CI, 1.9 to 2.4; P < .0001); HCC was an independent predictor of survival. Kaplan-Meier analysis showed a significant improvement in 5-year patient survival with time in patients with HCC (1987 to 1991, 25.3%; 1992 to 1996, 46.6%; 1997 to 2001, 61.1%; P < .0001). During the same period, there was only minimal improvement in survival among the control group. Conclusion: Five-year survival of patients transplanted for HCC is excellent, with a steady improvement in survival over the past decade. It is possible that the published criteria for patient selection may have contributed to the better outcome.

Impact of the alpha-Fetoprotein model for patient selection for Liver Transplantation for Hepatocellular Carcinoma, a French experience

2018 ◽  
Vol 68 ◽  
pp. S204-S205
Author(s):  
B. Brusset ◽  
Q.J. Louis ◽  
J. Dumortier ◽  
D. Cherqui ◽  
G.-P. Pageaux ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Alpha Fetoprotein ◽  
French Experience ◽  
Selection For

623 LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA BEYOND MILAN CRITERIA: POTENTIAL IMPACT OF UCSF CRITERIA IN PATIENT SELECTION

2011 ◽  
Vol 54 ◽  
pp. S252
Author(s):  
M.C. Bosso ◽  
G. Paraluppi ◽  
S. Mirabella ◽  
M.C. Saffioti ◽  
F. Manfredotti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Milan Criteria ◽  
Ucsf Criteria ◽  
Potential Impact

Multifocal manifestation does not affect vascular invasion of hepatocellular carcinoma: implications for patient selection in liver transplantation

2007 ◽  
Vol 0 (0) ◽  
pp. 070508211755005-??? ◽  
Author(s):  
Florian Löhe ◽  
Martin K Angele ◽  
Markus Rentsch ◽  
Christian Graeb ◽  
Alexander Gerbes ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Vascular Invasion

Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression?

2002 ◽  
pp. 1746-1751 ◽  
Author(s):  
Marco Vivarelli ◽  
Roberto Bellusci ◽  
Alessandro Cucchetti ◽  
Giulia Cavrini ◽  
Nicola De Ruvo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Recurrence Rate ◽  
Patient Selection

scholarly journals Liver Transplantation for Hepatocellular Carcinoma: How Should We Improve the Thresholds?

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 419
Author(s):  
Tsuyoshi Shimamura ◽  
Ryoichi Goto ◽  
Masaaki Watanabe ◽  
Norio Kawamura ◽  
Yasutsugu Takada
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Tumor Burden ◽  
Biological Behavior ◽  
Locoregional Therapy ◽  
Milan Criteria ◽  
Surrogate Markers ◽  
Patient Selection Criteria ◽  
Fdg Pet Ct

Hepatocellular carcinoma (HCC) is the third highest cause of cancer-related mortality, and liver transplantation is the ideal treatment for this disease. The Milan criteria provided the opportunity for HCC patients to undergo LT with favorable outcomes and have been the international gold standard and benchmark. With the accumulation of data, however, the Milan criteria are not regarded as too restrictive. After the implementation of the Milan criteria, many extended criteria have been proposed, which increases the limitations regarding the morphological tumor burden, and incorporates the tumor’s biological behavior using surrogate markers. The paradigm for the patient selection for LT appears to be shifting from morphologic criteria to a combination of biologic, histologic, and morphologic criteria, and to the establishment of a model for predicting post-transplant recurrence and outcomes. This review article aims to characterize the various patient selection criteria for LT, with reference to several surrogate markers for the biological behavior of HCC (e.g., AFP, PIVKA-II, NLR, 18F-FDG PET/CT, liquid biopsy), and the response to locoregional therapy. Furthermore, the allocation rules in each country and the present evidence on the role of down-staging large tumors are addressed.

scholarly journals Living donor liver transplantation for hepatocellular carcinoma: results of prospective patient selection by Kyushu University Criteria in 7 years

HPB ◽  
2017 ◽  
Vol 19 (12) ◽  
pp. 1082-1090 ◽  
Author(s):  
Hideaki Uchiyama ◽  
Shinji Itoh ◽  
Tomoharu Yoshizumi ◽  
Toru Ikegami ◽  
Norifumi Harimoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Patient Selection ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Donor Liver Transplantation
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