Early Increase of Retinal Arterial and Venous Blood Flow Velocities at Color Doppler Imaging in Brittle Type 1 Diabetes after Islet Transplant Alone

2006 ◽  
Vol 81 (9) ◽  
pp. 1274-1277 ◽  
Author(s):  
Massimo Venturini ◽  
Paolo Fiorina ◽  
Paola Maffi ◽  
Claudio Losio ◽  
Andrea Vergani ◽  
...  
2017 ◽  
Vol 27 (6) ◽  
pp. 751-755 ◽  
Author(s):  
Emine A. Sukgen ◽  
Gökhan Söker ◽  
Yusuf Koçluk ◽  
Bozkurt Gülek

Purpose To evaluate the blood flow changes of the central retinal artery measured with color Doppler imaging (CDI) in infants receiving intravitreal aflibercept (IVA) for treatment of type 1 retinopathy of prematurity (ROP). Methods Patients with type 1 ROP were assessed prospectively by CDI following IVA. Color Doppler imaging was used to measure the peak systolic velocity, end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) of the central retinal artery (CRA) before IVA injection and 1 hour, 1 week, and 1 month after injection. Results A total of 29 eyes of 15 infants were included in this study. The mean gestational age at birth was 28.62 ± 2.48 weeks and the mean birthweight was 1,198.62 ± 348.99 g. All treated eyes showed complete regression of ROP and peripheral retinal vascularization continued. Measurements of EDV-CRA, RI-CRA, and PI-CRA showed significant changes after IVA treatment. Conclusions This study showed that IVA is an effective treatment for type 1 ROP. After IVA treatment, vascular resistance increases, ocular blood flow decreases, and changes in hemodynamic parameters of CRA may remain for a month. Further studies are needed to evaluate the effect of anti-vascular endothelial growth factor agents on ocular hemodynamics in infants with ROP.


1998 ◽  
Vol 95 (4) ◽  
pp. 225-228 ◽  
Author(s):  
Frank Schüttauf ◽  
Ulrich Cobet ◽  
Albrecht Klemenz ◽  
Albrecht Krause

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