The Impact of Donor/Recipient Age Difference and HLA Matching on Graft Outcome in Pediatric Kidney Transplantation

Significant progress has been made in pediatric kidney transplantation. Advances in immunosuppression have dramatically decreased rates of acute rejection leading to improved short term graft survival but similar improvements in long term graft survival remain elusive. Changes in allocation policy provide the pediatric population with timely access to transplant but there remains concern about the impact of less HLA matching and a decrease in living donors. This report presents data from North America on these successes and the ongoing challenges that face the pediatric transplant community.

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Does donor–recipient age difference matter in outcome of kidney transplantation? Implications for kidney paired donation

Renal Failure ◽

10.3109/0886022x.2013.862769 ◽

2013 ◽

Vol 36 (3) ◽

pp. 378-383 ◽

Cited By ~ 5

Author(s):

Vivek B. Kute ◽

Aruna V. Vanikar ◽

Pankaj R. Shah ◽

Manoj R. Gumber ◽

Himanshu V. Patel ◽

...

Keyword(s):

Kidney Transplantation ◽

Age Difference ◽

Kidney Paired Donation ◽

Recipient Age

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ARTERIAL WALL MECHANICAL PROPERTIES AND KIDNEY GRAFT ARTERIAL STENOSIS

Journal of Mechanics in Medicine and Biology ◽

10.1142/s0219519406001832 ◽

2006 ◽

Vol 06 (02) ◽

pp. 209-214 ◽

Cited By ~ 1

Author(s):

L. COLÌ ◽

G. DONATI ◽

A. TEDESCO ◽

G. PALLOTTI ◽

P. PETTAZZONI ◽

...

Keyword(s):

Mechanical Properties ◽

Kidney Transplantation ◽

Renal Artery ◽

Arterial Wall ◽

Turbulent Fluxes ◽

Arterial Stenosis ◽

Age Difference ◽

Kidney Graft ◽

Atherosclerotic Stenosis ◽

Recipient Age

The connection of vascular segments with different mechanical properties increases the risk of generating blood turbulent fluxes, and involves the development of complications such as atherosclerosis in the arterial vessels. The mechanical properties of arterial vessel of two different subjects, the donor and the recipient, were analyzed. To experimentally validate the effects of the arterial wall mechanical properties on blood fluxes, 352 patients who received kidney transplantation were studied, concerning the development of renal artery atherosclerotic stenosis. An anastomothic arterial stenosis was observed in 92% of transplanted patients with donor/recipient age difference > 15 years, and in 5.7% of transplanted patients with donor/recipient age difference ≤ 15 years. In conclusion, it is useful to give more consideration to the patient's age difference in organ and vessel transplantations.

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The impact of donor and recipient age on the outcome of kidney transplantation

Transplantation Proceedings ◽

10.1016/j.transproceed.2004.07.047 ◽

2004 ◽

Vol 36 (7) ◽

pp. 2043-2045 ◽

Cited By ~ 17

Author(s):

O.J. Kwon ◽

H.G. Lee ◽

J.Y. Kwak

Keyword(s):

Kidney Transplantation ◽

Recipient Age ◽

The Impact

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Clinical Relevance of HLA Antibody Monitoring after Kidney Transplantation

Journal of Immunology Research ◽

10.1155/2014/845040 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 27

Author(s):

Christian Morath ◽

Gerhard Opelz ◽

Martin Zeier ◽

Caner Süsal

Keyword(s):

Risk Factors ◽

Kidney Transplantation ◽

Organ Transplantation ◽

Clinical Relevance ◽

De Novo ◽

Graft Loss ◽

Specific Antibodies ◽

Graft Outcome ◽

The Impact ◽

Hla Antibody

In kidney transplantation, antibody-mediated allograft injury caused by donor HLA-specific antibodies (DSA) has recently been identified as one of the major causes of late graft loss. This paper gives a brief overview on the impact of DSA development on graft outcome in organ transplantation with a focus on risk factors forde novoalloantibody induction and recently published guidelines for monitoring of DSA during the posttransplant phase.

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