scholarly journals PRE-TRANSPLANT INFUSION OF EXTRACORPOREAL PHOTOPHERESIS (ECP) TREATED DONOR SPLENOCYTES LEADS TO LONG-TERM LIVER ALLOGRAFT SURVIVAL AND DONOR SPECIFIC TOLERANCE IN RATS

2020 ◽  
Vol 104 (S3) ◽  
pp. S159-S159
Author(s):  
Yan Xie ◽  
Wentao Jiang ◽  
Jisan Sun
Keyword(s):  
Extracorporeal Photopheresis ◽  
Allograft Survival ◽  
Liver Allograft ◽  
Donor Specific Tolerance ◽  
Specific Tolerance

Induction of Tolerance for Long-Term Liver Allograft Survival Without Immunosuppression in Cynomolgus Monkeys

2018 ◽  
Vol 102 ◽  
pp. S261 ◽  
Author(s):  
Erik Berglund ◽  
Sulemon Chaudhry ◽  
Yojiro Kato ◽  
Joshua Weiner ◽  
Paula Alonso-Guallart ◽  
...  
Keyword(s):  
Allograft Survival ◽  
Liver Allograft ◽  
Cynomolgus Monkeys ◽  
Induction Of Tolerance

Long-Term Immunologic Induction of Donor-Specific Tolerance to Skin Allografts by Bone Marrow Transplant in Rabbits

2003 ◽  
Vol 111 (1) ◽  
pp. 291-297 ◽  
Author(s):  
Yi Biao Wang ◽  
Yutaka Ogawa ◽  
Hideaki Doi ◽  
Kenji Kusumoto ◽  
Tie Nan Jin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Skin Allografts ◽  
Donor Specific Tolerance ◽  
Specific Tolerance

Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK5061

2003 ◽  
Vol 75 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Zhenfan Yang ◽  
Xiaobing Wu ◽  
Tung-Yu Tsui ◽  
Yunde Hou ◽  
John M. Luk ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Low Dose ◽  
Combined Treatment ◽  
Allograft Survival ◽  
Liver Allograft

Long-Term Immunologic Induction of Donor-Specific Tolerance to Skin Allografts by Bone Marrow Transplant in Rabbits

2003 ◽  
Vol 111 (1) ◽  
pp. 291-297 ◽  
Author(s):  
Yi Biao Wang ◽  
Yutaka Ogawa ◽  
Hideaki Doi ◽  
Kenji Kusumoto ◽  
Tie Nan Jin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplant ◽  
Marrow Transplant ◽  
Skin Allografts ◽  
Donor Specific Tolerance ◽  
Specific Tolerance

scholarly journals The Need for Inducing Tolerance in Vascularized Composite Allotransplantation

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kadiyala V. Ravindra ◽  
Hong Xu ◽  
Larry D. Bozulic ◽  
David D. Song ◽  
Suzanne T. Ildstad
Keyword(s):  
Solid Organ Transplantation ◽  
Tolerance Induction ◽  
Mixed Chimerism ◽  
Future Research ◽  
Solid Organ ◽  
Vascularized Composite Allotransplantation ◽  
Split Tolerance ◽  
Donor Specific Tolerance ◽  
Specific Tolerance

Successful hand and face transplantation in the last decade has firmly established the field of vascularized composite allotransplantation (VCA). The experience in VCA has thus far been very similar to solid organ transplantation in terms of the morbidity associated with long-term immunosuppression. The unique immunological features of VCA such as split tolerance and resistance to chronic rejection are being investigated. Simultaneously there has been laboratory work studying tolerogenic protocols in animal VCA models. In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. This article reviews the immunology, animal models, mixed chimerism & tolerance induction in VCA and the direction of future research to enable better understanding and wider application of VCA.

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