Unusual Femur Stress Fractures in Children With Osteogenesis Imperfecta and Intramedullary Rods on Long-term Intravenous Pamidronate Therapy

2016 ◽  
Vol 36 (7) ◽  
pp. 757-761 ◽  
Author(s):  
Abdelsalam Hegazy ◽  
Mohamed Kenawey ◽  
Etienne Sochett ◽  
Lianne Tile ◽  
Angela M. Cheung ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Stress Fractures ◽  
Fractures In Children ◽  
Intravenous Pamidronate ◽  
Pamidronate Therapy

Intravenous Pamidronate Therapy in Osteogenesis Imperfecta

2007 ◽  
Vol 27 (2) ◽  
pp. 225-227 ◽  
Author(s):  
Anurag Bajpai ◽  
Madhulika Kabra ◽  
Neerja Gupta ◽  
Sheetal Sharda ◽  
Manju Ghosh
Keyword(s):  
Osteogenesis Imperfecta ◽  
Intravenous Pamidronate ◽  
Pamidronate Therapy

Efficacy of Cyclic Intravenous Pamidronate Therapy for Children with Osteogenesis Imperfecta

2003 ◽  
Vol 38 (7) ◽  
pp. 741 ◽  
Author(s):  
Tae Joon Cho ◽  
Moon Seok Park ◽  
In Ho Choi ◽  
Chin Youb Chung ◽  
Won Joon Yoo
Keyword(s):  
Osteogenesis Imperfecta ◽  
Intravenous Pamidronate ◽  
Pamidronate Therapy

Osteogenesis imperfecta — Clinical outcomes after a 4-year experience with cyclical intravenous pamidronate therapy

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S59
Author(s):  
L.C. Castro ◽  
C.C. Santos ◽  
M.L. Campos ◽  
K.P. Gameleira ◽  
M.G. Rorato ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Clinical Outcomes ◽  
Intravenous Pamidronate ◽  
Pamidronate Therapy

scholarly journals The Role of Pamidronate in Pediatric Patients with Severe Osteogenesis Imperfecta

2004 ◽  
Vol 9 (1) ◽  
pp. 27-35
Author(s):  
Jennifer L. Tsuji ◽  
Katherine P. Smith
Keyword(s):  
Osteogenesis Imperfecta ◽  
Bone Fragility ◽  
Clinical Severity ◽  
Long Term Effects ◽  
Fractures In Children ◽  
Wide Range ◽  
Col1a2 Gene ◽  
Adults And Children ◽  
Blue Sclerae ◽  
Pamidronate Therapy

Osteogenesis imperfecta (OI) is a heritable bone disorder with clinical features that include bone fragility, blue sclerae, and short stature. There are four main subtypes of OI, encompassing a wide range of clinical severity. The majority of patients have mutations in either the COL1A1 or COL1A2 gene that ultimately lead to an abnormal synthesis of or a decrease in the production of collagen. Bisphosphonates have been used effectively in adults and children to treat other bone disorders, since they have been proven to increase bone density through inhibition of bone resorption. Recent studies have demonstrated the advantages of pamidronate therapy in the treatment of children and adolescents with the more severe forms of OI. Pamidronate consistently increases bone mass, vertebral growth, and quality-of-life while decreasing the number of fractures in children with severe OI. Long-term effects are promising, and benefits of pamidronate therapy appear to outweigh the possible risks.

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