scholarly journals Atypical Case of POEMS Presented as Demyelinating Polyneuropathy With Motor Conduction Block

2021 ◽  
Vol 23 (2) ◽  
pp. 116-118
Author(s):  
Stacey Y. Guo ◽  
Alexandra O. Duffy ◽  
Ricardo A. Maselli ◽  
Ge Xiong
Keyword(s):  
Conduction Block ◽  
Demyelinating Polyneuropathy ◽  
Atypical Case

Case 18

2018 ◽  
Author(s):  
Bashar Katirji
Keyword(s):  
Monoclonal Gammopathy ◽  
Compound Muscle Action Potential ◽  
Conduction Block ◽  
Demyelinating Polyneuropathy ◽  
Type I ◽  
Charcot Marie Tooth Disease ◽  
Immune Mediated ◽  
Muscle Action Potential ◽  
Unknown Significance ◽  
Distinguishing Features

Immune-mediated polyneuropathies are important to recognize since the majority of them are treatable. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the prototype of the acquired chronic demyelinating polyneuropathies. It should be distinguished from other acquired demyelinating polyneuropathy such as those associated with monoclonal gammopathy, myeloproliferative disorder, and myelin-associated glycoprotein. This case presents a patient with a chronic demyelinating polyneuropathy associated with monoclonal gammopathy of unknown significance. The discussion includes the clinical and electrodiagnostic criteria for CIDP and distinguishing features from axonal polyneuropathies, other acquired demyelinating polyneuropathies, and inherited demyelinating polyneuropathies such as Charcot-Marie-Tooth disease type I. The case also highlights the diagnostic criteria for conduction block and temporal dispersion based on analysis of compound muscle action potential amplitude, area, and duration.

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