Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors

2019 ◽  
Vol 42 (5) ◽  
pp. 413-420 ◽  
Author(s):  
Hiral A. Shah ◽  
James H. Fischer ◽  
Neeta K. Venepalli ◽  
Oana C. Danciu ◽  
Sonia Christian ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Vegfr Inhibitor

A phase I study of MK-5108, an oral aurora A kinase inhibitor, in both monotherapy and in combination with docetaxel in patients with advanced solid tumors.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e13026-e13026 ◽  
Author(s):  
S. E. Minton ◽  
P. LoRusso ◽  
A. C. Lockhart ◽  
M. Saif ◽  
S. S. Krishnamurthi ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors ◽  
Aurora A Kinase ◽  
Aurora A

Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations

2012 ◽  
Vol 18 (17) ◽  
pp. 4775-4784 ◽  
Author(s):  
E. Claire Dees ◽  
Roger B. Cohen ◽  
Margaret von Mehren ◽  
Thomas E. Stinchcombe ◽  
Hua Liu ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Oral Formulations

STM-01: Phase I EffTox study of aurora A kinase inhibitor alisertib (MLN8237) given in combination with selective VEGFR inhibitor pazopanib for therapy of solid tumors.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 2587-2587 ◽  
Author(s):  
Hiral A. Shah ◽  
Sonia Christian ◽  
Bilawal Ahmed ◽  
Rozina A. Chowdhery ◽  
Neeta K. Venepalli ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Kinase Inhibitor ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Vegfr Inhibitor

STM-01: Phase I EFFTox study of aurora A kinase inhibitor alisertib (MLN8237) given in combination with selective VEGFR inhibitor pazopanib for therapy of solid tumors.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. TPS2610-TPS2610
Author(s):  
Arkadiusz Z. Dudek ◽  
Imran Unal ◽  
Hui Xie ◽  
Lawrence Eric Feldman ◽  
Neeta K. Venepalli ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Kinase Inhibitor ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Vegfr Inhibitor

scholarly journals Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors

2012 ◽  
Vol 18 (17) ◽  
pp. 4764-4774 ◽  
Author(s):  
Andres Cervantes ◽  
Elena Elez ◽  
Desamparados Roda ◽  
Jeffrey Ecsedy ◽  
Teresa Macarulla ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Pharmacodynamic Study

scholarly journals A phase I study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with docetaxel, in patients with advanced or refractory solid tumors

2015 ◽  
Vol 34 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Manik Amin ◽  
Susan E. Minton ◽  
Patricia M. LoRusso ◽  
Smitha S. Krishnamurthi ◽  
Cheryl A. Pickett ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Aurora A Kinase ◽  
Aurora A

scholarly journals Phase I Study of Bosutinib, a Src/Abl Tyrosine Kinase Inhibitor, Administered to Patients with Advanced Solid Tumors

2011 ◽  
Vol 18 (4) ◽  
pp. 1092-1100 ◽  
Author(s):  
Adil I. Daud ◽  
Smitha S. Krishnamurthi ◽  
Mansoor N. Saleh ◽  
Barbara J. Gitlitz ◽  
Mitesh J. Borad ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Phase I ◽  
Tyrosine Kinase Inhibitor ◽  
Solid Tumors ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Advanced Solid Tumors ◽  
Abl Tyrosine Kinase ◽  
Abl Tyrosine Kinase Inhibitor

scholarly journals Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma

2018 ◽  
Vol 24 (24) ◽  
pp. 6150-6159 ◽  
Author(s):  
Kevin R. Kelly ◽  
Jonathan W. Friedberg ◽  
Steven I. Park ◽  
Kevin McDonagh ◽  
John Hayslip ◽  
...  
Keyword(s):  
Phase I ◽  
B Cell ◽  
Phase I Study ◽  
Kinase Inhibitor ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Aggressive B Cell Lymphoma
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