T follicular helper cells and HIV/SIV-specific antibody responses

2014 ◽  
Vol 9 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Constantinos Petrovas ◽  
Richard A. Koup
Keyword(s):  
Specific Antibody ◽  
Antibody Responses ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Heather D Marshall ◽  
John P Ray ◽  
Brian J Laidlaw ◽  
Nianzhi Zhang ◽  
Dipika Gawande ◽  
...  
Keyword(s):  
T Cells ◽  
Transforming Growth Factor Beta ◽  
Cd4 T Cells ◽  
Transforming Growth Factor ◽  
Antibody Responses ◽  
T Follicular Helper Cells ◽  
High Affinity ◽  
Tfh Cells ◽  
Helper Cells ◽  
Follicular Helper

T follicular helper cells (Tfh) are crucial for the initiation and maintenance of germinal center (GC) reactions and high affinity, isotype-switched antibody responses. In this study, we demonstrate that direct TGF-β signaling to CD4 T cells is important for the formation of influenza-specific Tfh cells, GC reactions, and development of isotype-switched, flu-specific antibody responses. Early during infection, TGF-β signaling suppressed the expression of the high affinity IL-2 receptor α chain (CD25) on virus-specific CD4 T cells, which tempered IL-2 signaling and STAT5 and mammalian target of rapamycin (mTOR) activation in Tfh precursor CD4 T cells. Inhibition of mTOR allowed for the differentiation of Tfh cells in the absence of TGF-βR signaling, suggesting that TGF-β insulates Tfh progenitor cells from IL-2-delivered mTOR signals, thereby promoting Tfh differentiation during acute viral infection. These findings identify a new pathway critical for the generation of Tfh cells and humoral responses during respiratory viral infections.

The right adjuvant gives T follicular helper cells a boost

2019 ◽  
Vol 11 (497) ◽  
pp. eaax9565
Author(s):  
Michelle Boyle
Keyword(s):  
Antibody Responses ◽  
Vaccine Adjuvant ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
The Right

The vaccine adjuvant GLA-SE increases the magnitude and longevity of antibody responses by increasing the quantity of T follicular helper cells in humans.

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