scholarly journals Deciphering the molecular basis of human cardiovascular disease through network biology

2012 ◽  
Vol 27 (3) ◽  
pp. 202-209 ◽  
Author(s):  
Stephen Y. Chan ◽  
Kevin White ◽  
Joseph Loscalzo
Keyword(s):  
Cardiovascular Disease ◽  
Molecular Basis ◽  
Network Biology

Molecular Basis of Obesity and the Risk for Cardiovascular Disease

Herz ◽  
2006 ◽  
Vol 31 (3) ◽  
pp. 200-206 ◽  
Author(s):  
Muhidien Soufi ◽  
Alexander M. Sattler ◽  
Matthias Herzum ◽  
Bernhard Maisch ◽  
Jürgen R. Schaefer
Keyword(s):  
Cardiovascular Disease ◽  
Molecular Basis

scholarly journals The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

2021 ◽  
Vol 128 (2) ◽  
pp. 287-303
Author(s):  
Matthew Nayor ◽  
Kemar J. Brown ◽  
Ramachandran S. Vasan
Keyword(s):  
Cardiovascular Disease ◽  
Molecular Basis ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Molecular Data ◽  
High Dimensional ◽  
Atherosclerotic Cardiovascular Disease ◽  
Molecular Signatures ◽  
Atherosclerotic Cardiovascular Disease Risk ◽  
The Life Course

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual’s atherosclerotic cardiovascular disease risk status throughout the life course.

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