scholarly journals Research Progress on the Pathogenesis of Hemorrhagic Fever with Renal Syndrome

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hong Du ◽  
Pingzhong Wang ◽  
Xuefan Bai ◽  
Jing Li ◽  
Xiaoyan Wang ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Keke Wu ◽  
Shuangqi Fan ◽  
Linke Zou ◽  
Feifan Zhao ◽  
Shengming Ma ◽  
...  

Diseases caused by Flaviviridae have a wide global and economic impact due to high morbidity and mortality. Flaviviridae infection usually leads to severe, acute or chronic diseases, such as liver injury and liver cancer resulting from hepatitis C virus (HCV) infection, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) caused by dengue virus (DENV). Given the highly complex pathogenesis of Flaviviridae infections, they are still not fully understood at present. Accumulating evidence suggests that host autophagy is disrupted to regulate the life cycle of Flaviviridae. Organelle-specific autophagy is able to selectively target different organelles for quality control, which is essential for regulating cellular homeostasis. As an important sub process of autophagy, lipophagy regulates lipid metabolism by targeting lipid droplets (LDs) and is also closely related to the infection of a variety of pathogenic microorganisms. In this review, we briefly understand the LDs interaction relationship with Flaviviridae infection, outline the molecular events of how lipophagy occurs and the related research progress on the regulatory mechanisms of lipophagy in Flaviviridae infection. Exploring the crosstalk between viral infection and lipophagy induced molecular events may provide new avenues for antiviral therapy.


2016 ◽  
Vol 4 (4) ◽  
pp. 259-262
Author(s):  
Maria Saleem ◽  
◽  
Syed Zawar Shah ◽  
Asma Haidari ◽  
Fatima Idrees ◽  
...  

2015 ◽  
Vol 4 (2) ◽  
pp. 37
Author(s):  
Yunpeng Wang ◽  
Yuchen Zhang

<p>Ebola hemorrhagic fever is a potent infectious disease by Ebola virus caused 90% mortality rate. Ebola virus was first isolated in 1976 by, for single-stranded negative segment, non-segmented, enveloped RNA viruses belonging to filamentous virus family. Ebola virus can be divided into five different subtypes. Vaccination is the most conventional and effective prevention and infection control methods in recent years. It has made great progress in the study on the vaccine for Ebola virus. In this paper, research progress Ebola hemorrhagic fever vaccine was reviewed.</p>


2019 ◽  
Vol 227 (1) ◽  
pp. 64-82 ◽  
Author(s):  
Martin Voracek ◽  
Michael Kossmeier ◽  
Ulrich S. Tran

Abstract. Which data to analyze, and how, are fundamental questions of all empirical research. As there are always numerous flexibilities in data-analytic decisions (a “garden of forking paths”), this poses perennial problems to all empirical research. Specification-curve analysis and multiverse analysis have recently been proposed as solutions to these issues. Building on the structural analogies between primary data analysis and meta-analysis, we transform and adapt these approaches to the meta-analytic level, in tandem with combinatorial meta-analysis. We explain the rationale of this idea, suggest descriptive and inferential statistical procedures, as well as graphical displays, provide code for meta-analytic practitioners to generate and use these, and present a fully worked real example from digit ratio (2D:4D) research, totaling 1,592 meta-analytic specifications. Specification-curve and multiverse meta-analysis holds promise to resolve conflicting meta-analyses, contested evidence, controversial empirical literatures, and polarized research, and to mitigate the associated detrimental effects of these phenomena on research progress.


2002 ◽  
Author(s):  
Raymond A. Levy ◽  
Stuart Ablon
Keyword(s):  

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