scholarly journals Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma

2018 ◽  
Vol 27 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Li Zhu ◽  
Yuan Zong ◽  
Jian Yu ◽  
Chunhui Jiang ◽  
Yi He ◽  
...  
Keyword(s):  
Retinal Vessel ◽  
Angle Closure Glaucoma ◽  
Vessel Density ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Retinal Vessel Density

scholarly journals Spatial positional relationship between macular superficial vessel density and ganglion cell-inner plexiform layer thickness in primary angle closure glaucoma

2021 ◽  
Author(s):  
Yongdong Lin ◽  
Di Ma ◽  
Hongxi Wang ◽  
Shirong Chen ◽  
Weihao Cai ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Strong Correlation ◽  
Plexiform Layer ◽  
Angle Closure Glaucoma ◽  
Vessel Density ◽  
Angle Closure ◽  
Inner Plexiform Layer ◽  
Swept Source ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Abstract Purpose To evaluate the spatial relationship between macular superficial vessel density (SVD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in primary angle closure glaucoma (PACG), and to investigate diagnostic abilities of macular SVD and foveal avascular zone (FAZ) parameters. Methods This was a cross-sectional study on 38 PACG patients (38 eyes) and 25 healthy subjects (25 eyes). Macular region was imaged using a 1050-nm-wavelength swept-source optical coherence tomography (OCT) angiography (OCTA) system (DRI OCT Triton, TOPCON). Vessel density of the macular region was quantified by ImageJ software. The peripapillary retinal nerve fiber layer (pRNFL) thicknesses and macular GCIPL thickness were obtained by swept-source OCT. Pearson correlation analysis was used to evaluate the spatial positional relationship between macular SVD and macular GCIPL thickness. At the same time, the correlation between macular SVD and pRNFL thickness was evaluated. Areas under the receiver operating characteristics curves (AUCs) of OCT, OCTA and FAZ measurement metrics were calculated to assess the diagnostic ability for glaucoma. Results Macular GCIPL thickness had a moderate correlation with the macular SVD in the inferonasal sector (r = 0.426, P = 0.008). In addition, there was a strong correlation between inferonasal sector of macular vessel density and 5,6,7,8 clock-hour regions of the pRNFL thicknesses (all r > 0.5). Inferoinferior sector of macular SVD and 6,7 clock-hour regions of pRNFL thicknesses also had strong correlation (all r > 0.5). The AUCs of macular SVD ranged between 0.61 (superonasal sector) and 0.76 (inferoinferior sector). The FAZ circularity index showed the highest diagnostic power (AUC = 0.94;95% CI, 0.85–0.99), followed by superotemporal sector of macular GCIPL thicknesses (0.93;95% CI,0.83–0.98). Conclusions Sector of macular SVD not only had a spatial positional correlation with corresponding macular GCIPL thickness, but also with clock-hour regional pRNFL thicknesses in PACG eyes. FAZ circulation index might be a useful diagnostic parameter.

Spatial Positional Relationship Between Macular Superficial Vessel Density and Ganglion Cell-Inner Plexiform Layer Thickness in Primary Angle Closure Glaucoma

2021 ◽  
Author(s):  
Yongdong Lin ◽  
Di Ma ◽  
Hongxi Wang ◽  
Shirong Chen ◽  
Mingzhi Zhang
Keyword(s):  
Ganglion Cell ◽  
Strong Correlation ◽  
Plexiform Layer ◽  
Angle Closure Glaucoma ◽  
Vessel Density ◽  
Angle Closure ◽  
Inner Plexiform Layer ◽  
Swept Source ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma

Abstract Purpose: To evaluate the spatial relationship between macular superficial vessel density (SVD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in primary angle-closure glaucoma (PACG), and to investigate diagnostic abilities of macular SVD and foveal avascular zone (FAZ) parameters.Methods: This was a cross-sectional study on 38 PACG patients (38 eyes) and 25 healthy subjects (25 eyes). Macular region was imaged using a 1050-nm-wavelength swept-source optical coherence tomography (OCT) angiography (OCTA) system (DRI OCT Triton, TOPCON). Vessel density of the macular region was quantified by ImageJ software. The peripapillary retinal nerve fiber layer (pRNFL) thicknesses and macular GCIPL thickness were obtained by swept-source OCT. Pearson correlation analysis was used to evaluate the spatial positional relationship between macular SVD and macular GCIPL thickness. At the same time, the correlation between macular SVD and pRNFL thickness was evaluated. Areas under the receiver operating characteristics curves (AUCs) of OCT, OCTA and FAZ measurement metrics were calculated to assess the diagnostic ability for glaucoma.Results: Macular GCIPL thickness had a moderate correlation with the macular SVD in the inferonasal sector (r = 0.426, P = 0.008). In addition, there was a strong correlation between inferonasal sector of macular vessel density and 5,6,7,8 clock-hour regions of the pRNFL thicknesses(all r>0.5). Inferoinferior sector of macular SVD and 6,7 clock-hour regions of pRNFL thicknesses also had strong correlation (all r>0.5).The AUCs of macular SVD ranged between 0.61 (superonasal sector) and 0.76 (inferoinferior sector).The FAZ circularity index showed the highest diagnostic power (AUC= 0.94;95% CI, 0.85-0.99), followed by superotemporal sector of macular GCIPL thicknesses (0.93;95% CI,0.83-0.98).Conclusions: Sector of macular SVD not only had a spatial positional correlation with corresponding macular GCIPL thickness, but also with clock-hour regional pRNFL thicknesses in PACG eyes. FAZ circulation index might be a useful diagnostic parameter.

scholarly journals Vessel Density and Structural Measurements in Primary Angle-Closure Suspect Glaucoma Using Optical Coherence Tomography Angiography

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yi Zha ◽  
Juanjuan Chen ◽  
Shuyu Liu ◽  
Jinfei Zhuang ◽  
Jianqiu Cai
Keyword(s):  
Retinal Vessel ◽  
Normal Subjects ◽  
Vessel Density ◽  
Angle Closure ◽  
Control Group ◽  
Fiber Layer ◽  
Primary Angle Closure ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Retinal Vessel Density

Purpose. To measure the macular retinal vessel density (VD) and peripapillary retinal nerve fiber layer (RNFL) in primary angle-closure suspects (PACS) by Angio-OCT to be compared with normal subjects. Methods. Primary angle-closure suspect patients and normal subjects were enrolled in this study. The demographic and clinical characteristics of all subjects, such as RNFL thickness, retinal vessel density, and ocular perfusion pressure, were compared. Results. No significant difference was found in both groups on age, sex distribution, intraocular pressure (IOP), and retinal vessel density. The PACS group exhibited significantly thicker RNFL thickness compared with the control group. The deep vessel density was negatively associated with age ( P = − 0.034 ), while IOP had negative association with ACD ( P = − 0.019 ). OPP was independently associated with RNFL ( B = 0.334 , P = 0.038 ) in the PACS group. Conclusions. OCTA showed significant thicker change on RNFL in the PACS group. Only OPP was independently associated with RNFL in the PACS group.

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