scholarly journals Vessel Density and Structural Measurements in Primary Angle-Closure Suspect Glaucoma Using Optical Coherence Tomography Angiography

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yi Zha ◽  
Juanjuan Chen ◽  
Shuyu Liu ◽  
Jinfei Zhuang ◽  
Jianqiu Cai
Keyword(s):  
Retinal Vessel ◽  
Normal Subjects ◽  
Vessel Density ◽  
Angle Closure ◽  
Control Group ◽  
Fiber Layer ◽  
Primary Angle Closure ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Retinal Vessel Density

Purpose. To measure the macular retinal vessel density (VD) and peripapillary retinal nerve fiber layer (RNFL) in primary angle-closure suspects (PACS) by Angio-OCT to be compared with normal subjects. Methods. Primary angle-closure suspect patients and normal subjects were enrolled in this study. The demographic and clinical characteristics of all subjects, such as RNFL thickness, retinal vessel density, and ocular perfusion pressure, were compared. Results. No significant difference was found in both groups on age, sex distribution, intraocular pressure (IOP), and retinal vessel density. The PACS group exhibited significantly thicker RNFL thickness compared with the control group. The deep vessel density was negatively associated with age ( P = − 0.034 ), while IOP had negative association with ACD ( P = − 0.019 ). OPP was independently associated with RNFL ( B = 0.334 , P = 0.038 ) in the PACS group. Conclusions. OCTA showed significant thicker change on RNFL in the PACS group. Only OPP was independently associated with RNFL in the PACS group.

scholarly journals Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma

2018 ◽  
Vol 27 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Li Zhu ◽  
Yuan Zong ◽  
Jian Yu ◽  
Chunhui Jiang ◽  
Yi He ◽  
...  
Keyword(s):  
Retinal Vessel ◽  
Angle Closure Glaucoma ◽  
Vessel Density ◽  
Angle Closure ◽  
Primary Angle Closure ◽  
Primary Angle Closure Glaucoma ◽  
Retinal Vessel Density

scholarly journals Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kangcheng Liu ◽  
Huizhuo Xu ◽  
Haibo Jiang ◽  
Hua Wang ◽  
Pingbao Wang ◽  
...  
Keyword(s):  
Early Stage ◽  
Normal Subjects ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Circularity Index ◽  
Avascular Zone ◽  
And Control

Abstract This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.

scholarly journals Optic Disc Vascularization in Glaucoma: Value of Spectral-Domain Optical Coherence Tomography Angiography

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Pierre-Maxime Lévêque ◽  
Pierre Zéboulon ◽  
Emmanuelle Brasnu ◽  
Christophe Baudouin ◽  
Antoine Labbé
Keyword(s):  
Visual Field ◽  
Univariate Analysis ◽  
Normal Subjects ◽  
Vessel Density ◽  
Spectral Domain ◽  
Control Group ◽  
Mean Deviation ◽  
Ganglion Cell Complex ◽  
Fiber Layer ◽  
Spectral Domain Oct

Purpose. To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A).Material and Method. Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients. Correlations among total and temporal ONH vessel density and structural and VF parameters were analyzed.Results. In the glaucoma group, total and temporal ONH vessel density were reduced by 24.7% (0.412 versus 0.547;p<0.0001) and 22.88% (0.364 versus 0.472;p=0.001), respectively, as compared with the control group. Univariate analysis showed significant correlation between rim area (mm2) and temporal ONH vessel density (r=0.623;p<0.0001) and total ONH vessel density (r=0.609;p<0.0001). Significant correlations were found between temporal and total ONH vessel density and RNFL, GCC, VF mean deviation, and visual field index.Conclusion. In glaucoma patients OCT-A might detect reduced ONH blood vessel density that is associated with structural and functional glaucomatous damage. OCT-A might become a useful tool for the evaluation of ONH microcirculation changes in glaucoma.

scholarly journals Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study

2021 ◽  
Vol 10 (24) ◽  
pp. 5756
Author(s):  
Daniela Montorio ◽  
Roberta Lanzillo ◽  
Antonio Carotenuto ◽  
Maria Petracca ◽  
Marcello Moccia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Healthy Controls ◽  
Fiber Layer ◽  
Density Reduction ◽  
Capillary Plexus ◽  
Retinal Vessel Density ◽  
A Prospective Study

Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple sclerosis (MS) over the course of the disease. OCTA investigations at early MS stages are lacking. We aimed to investigate vessel density in macular and papillary regions over two years after an initial demyelinating event (IDE). Vessel density was analyzed in superficial, deep, choriocapillaris and radial peripapillary plexus at baseline, and after one and two years. We also evaluated structural OCT parameter changes of the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). We evaluated 30 eyes from 15 IDE patients (7 females, 8 males, mean age 28.4 ± 9.6 years) and 30 eyes from 15 healthy controls. After 2 years, we reported in the IDE group a reduced vessel density in the superficial capillary plexus, deep capillary plexus and radial peripapillary capillary plexus with respect to the baseline (coeff. β = −2.779, p = 0.013; coeff. β = −4.055, p = 0.018 and coeff. β = −2.687, p ≤ 0.001; respectively), while GCC and RNFL thicknesses did not change. Vessel density reduction was not associated with an expanded disability status scale (EDSS) change, relapse occurrence or magnetic resonance imaging activity. The analysis of healthy controls did not reveal any impairment in OCT and OCTA parameters over 2 years of follow-up. Retinal vascular loss occurs in patients with an IDE independently from clinical and radiological disease activity. Retinal vessel density could represent a novel early biomarker to monitor the MS pathological burden.

scholarly journals Ocular Biometry among primary angle closure

2018 ◽  
Vol 8 (1) ◽  
pp. 5-9
Author(s):  
Dakki Sherpa
Keyword(s):  
Risk Factor ◽  
Sampling Technique ◽  
Normal Subjects ◽  
Angle Closure ◽  
Control Group ◽  
Cross Sectional ◽  
Primary Angle Closure ◽  
Ocular Biometry ◽  
Lens Diameter ◽  
The Mean

Objective: To determine ocular biometry of primary angle closure. Materials and methods: A cross-sectional compara­tive study was carried out in Nepal Eye Hospital including thirty-six eyes of 29 diagnosed cases of primary angle closure and 44 eyes of 22 normal subjects selected by convenience sampling technique. A complete ocular examination of all the subjects was carried out. AL, ACD and LD measurement was done using ultrasound A scan. Result: Out of 80 eyes, there were 36 eyes of 29 diagnosed primary angle closure subjects and 44 eyes of 22 normal subjects. The mean age of primary angle closure patients were 61. 65+/- 10.44. The mean AL of PAC was 22.15mm +/-0.76. The mean AL of control group was 22.98 mm with SD of 0.63. The mean ACD of PAC patients were 2.85mm and SD of 0.46 and the mean ACD of control group was 3.59 with SD of .40. The mean lens diameter of PAC group was 4.57 mm +/- 0.58 and the mean LD of control group was 4.43mm +/- 0.54. The Sig (2-tailed) test showed: Age: 0.268, AL: 0.001, ACD: 0.000 and LD: 0.466. Conclusion: This study reveals that short AL and shallow ACD is a strong risk factor of primary angle closure. Though LD more than 4.5 mm is a risk factor of primary angle closure it is not statistically significant.

scholarly journals Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders

2019 ◽  
Vol 104 (2) ◽  
pp. 282-290 ◽  
Author(s):  
Jacqueline Chua ◽  
Florian Schwarzhans ◽  
Duc Quang Nguyen ◽  
Yih Chung Tham ◽  
Josh Tjunrong Sia ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Eye Diseases ◽  
Vessel Density ◽  
Rnfl Thickness ◽  
Nerve Fibre Layer ◽  
Retinal Vessel Density ◽  
Sd Oct

Background/AimsTo compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders.MethodsThe Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc centres (fovea distance) and their respective angle (fovea angle). Retinal vessels were segmented in the projection images and used to calculate the circumpapillary retinal vessel density profile. Compensated RNFL thickness was generated based on optic disc (ratio, orientation and area), fovea (distance and angle), retinal vessel density, refractive error and age. Linear regression models were used to investigate the effects of clinical factors on RNFL thickness.ResultsRetinal vessel density reduced significantly with increasing age (1487±214 µm in 40–49, 1458±208 µm in 50–59, 1429±223 µm in 60–69 and 1415±233 µm in ≥70). Compensation reduced the variability of RNFL thickness, where the effect was greatest for Chinese (10.9%; p<0.001), followed by Malays (6.6%; p=0.075) and then Indians (4.3%; p=0.192). Compensation reduced the age-related RNFL decline by 55% in all participants (β=−3.32 µm vs β=−1.50 µm/10 years; p<0.001). Nearly 62% of the individuals who were initially classified as having abnormally thin RNFL (outside the 99% normal limits) were later reclassified as having normal RNFL.ConclusionsRNFL thickness compensated for anatomical parameters reduced the variability of measurements and may improve glaucoma detection, which needs to be confirmed in future studies.

scholarly journals The Impact of Chronic Heart Failure on Retinal Vessel Density Assessed by Optical Coherence Tomography Angiography in Children with Dilated Cardiomyopathy

2021 ◽  
Vol 10 (12) ◽  
pp. 2659
Author(s):  
Klaudia Rakusiewicz ◽  
Krystyna Kanigowska ◽  
Wojciech Hautz ◽  
Lidia Ziółkowska
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Vessel ◽  
Left Ventricular ◽  
Vessel Density ◽  
Control Group ◽  
Study Group ◽  
Capillary Plexus ◽  
Retinal Vessel Density

(1) Introduction: The aim of this study is to assess retinal vessel density (VD) in the superficial capillary plexus layer (SP) and deep capillary plexus layer (DP) in children with chronic heart failure (CHF) in the course of dilated cardiomyopathy (DCM) using optical coherence tomography angiography (OCTA). (2) Methods: Thirty children with CHF due to DCM lasting more than six months, with an enlarged left ventricle and impaired left ventricular systolic function (left ventricular ejection fraction (LVEF) ≤ 55%), were enrolled to have both their eyes assessed for this study. Mean age of the children was 9.9 ± 3.57 years. The control group consisted of an additional 30 children without CHF (mean age 11.27 ± 3.33 years) matched for age and gender against the study group. All participants underwent transthoracic echocardiography to measure LVEF using Simpson method. Blood serum was tested for N-terminal-pro-brain natriuretic peptide (NT-proBNP) marker value. All children underwent OCTA with evaluation of the foveal avascular zone (FAZ), whole superficial vessel density (wsVD), foveal superficial vessel density (fsVD), parafoveal superficial vessel density (psVD), whole deep vessel density (wdVD), foveal deep vessel density (fdVD), parafoveal deep vessel density (pdVD), whole thickness (WT), foveal thickness (FT), and parafoveal thickness (PFT). (3) Results: Retinal VD in SP was significantly lower in children with CHF as compared to the controls. The following SP parameters in the study group were statistically significantly lower than these same measurements for the control group. Details, with study group findings quantified first, include wsVD (46.2% vs. 49.83%, p < 0.05), fsVD (18.07% vs. 24.15%, p < 0.05), and psVD (49.24% vs. 52.51%, p < 0.05). The WT (311.03 micrometers (μm) vs. 323.55 μm, p < 0.05), FT (244.57 μm vs. 256.98 μm, p < 0.05), and PFT (320.63 μm vs. 332.02 μm, p < 0.05). No significant differences in DP retinal VD were found between the two groups. No statistically significant differences in the FAZ were found. The fsVD and FT were correlated with biometry and the age of the study participants. There was a correlation between FAZ and FT (p < 0.001). There were no correlations between retinal VD in both plexuses and refractive error, sex, NT-proBNP, and LVEF. (4) Conclusions: In children with CHF in the course of DCM as compared to the control group, significantly decreased retinal VD in SP was observed. The results of our study indicate that measurements of the OCTA may be a useful diagnostic method in children with chronic heart failure, but it is necessary to conduct further studies in larger groups of participants and long-term observation of these patients.

scholarly journals Optical Coherence Tomography Angiography of The Macular Microcirculation in Acute Primary Angle Closure Treated With Phacoemulsification

2021 ◽  
Author(s):  
Lin Fu ◽  
Yau Kei Chan ◽  
Jia Fang ◽  
Junbo Liu ◽  
Shumei Wen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Angle Closure ◽  
Field Pattern ◽  
Control Group ◽  
Optical Coherence ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Normal Individuals

Abstract Purpose To measure the changes of macular microcirculation in cases with unilateral acute primary angle closure (APAC) who were managed by phacoemulsification. Methods Patients with unilateral APAC and managed by phacoemulsification were enrolled. The contralateral unaffected eyes were served as fellow group, and normal individuals were recruited as control group. Optical coherence tomography angiography (OCT-A) was performed to analyse the macular whole image vessel density (wiVD) and parafoveal vessel density (pfVD). The retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses were assessed using spectral-domain optical coherence tomography. Results A total of 36 APAC patients and 35 eyes from 35 normal individuals were recruited. In the APAC eyes, the mean wiVD (42.1% ± 3.7%) and pfVD (45.2% ± 3.8%) in the superficial layers (wiVD-SL and pfVD-SL) were both significantly reduced, compared to fellow eyes (45.7% ± 3.1%, 48.7% ±3.1%) and control eyes (44.4% ± 4.7%, 47.4% ± 5.1%) (P < 0.05). They were all statistically correlated with RNFL, GCC, visual field pattern standard deviation (PSD), and mean deviation (MD). Conclusion The macular OCT-A parameters including wiVD-SL and pfVD-SL were significantly reduced in the eyes with APAC compared the fellow unaffected eyes and normal control eyes. They were correlated well with RNFL, GCC, PSD and MD. The macular vessel density parameters may help monitor the progression of APAC.

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