Re: “Hyperbaric Oxygen Therapy as Further Adjunctive Therapy in Group A Streptococcus Periorbital Necrotizing Fasciitis”

PURPOSE: To evaluate hyperbaric oxygen therapy (HBO) after esophagojejunal anastomosis in a rat experimental model and the effect of HBO on the healing of esophagojejunal anastomosis in gastrectomized rats. METHODS: Forty adult male Wistar rats, weighing 322 g to 506 g, were divided into two random groups. In group A (control group), 20 rats were subjected to total gastrectomy. In group B, 20 rats were similarly gastrectomized, but also received postoperative HBO treatment for 90 minutes/day for seven days. All rats were sacrificed on the eighth postoperative day and evaluated according to the following study variables: a) presence of anastomotic fistula; b) evaluation of esophagojejunal anastomosis healing by measuring the breaking strength at the suture line as per Hendriks & Mastboom; and c) determining the collagen concentration in the anastomosis, as per Kovács criteria. For the comparative statistical analysis between groups, Student's "t" test was used. A value of p<0.05 was considered significant. RESULTS: There was a 20% mortality rate. There were five deaths in group A and three in group B (p=N.S.). There was only one anastomotic fistula in each group, and neither caused any morbidity or death. Breaking strength measured at the suture line (p=0.528) and collagen concentration determined at the esophagojejunal anastomosis (p=0.89) were not significantly different between Groups A and B. CONCLUSION: Hyperbaric oxygen therapy did not affect the healing process of esophagojejunal anastomosis.

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Research on the Possibility of Treating Streptococcal Infections with Hyperbaric Oxygenation

Polish Hyperbaric Research ◽

10.2478/phr-2020-0003 ◽

2020 ◽

Vol 70 (1) ◽

pp. 43-46

Author(s):

Władysław Wolański

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Hyperbaric Oxygenation ◽

Lethal Effect ◽

Streptococcal Infections ◽

Group A

AbstractThe aim of the study was to determine the effect of the application of hyperbaric oxygen therapy on the course of an infection with group A type T-3 hemolytic β streptococcus. Experiments were carried out on Porton white mice and in vitro blood plates. General and local infections with streptococci were induced in animals. The infected animals were treated with hyperbaric oxygenation. The lethal effect of infection was significantly inhibited using hyperbaric oxygenation on the first and second day following the infection.

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Adjunctive Therapy Application of Hyperbaric Oxygen Therapy in Children Already Treated with Mild Hypothermia for Disturbance of Consciousness

Hypothermia for Acute Brain Damage ◽

10.1007/978-4-431-53961-2_25 ◽

2004 ◽

pp. 174-177

Author(s):

Hiroshi Dohgomori ◽

Kazuhiro Arikawa ◽

Hiroaki Iwaya ◽

Ri Matsubayashi ◽

Ichiro Kukita ◽

...

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Adjunctive Therapy ◽

Oxygen Therapy ◽

Mild Hypothermia ◽

Disturbance Of Consciousness

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Effect of hyperbaric oxygen therapy in rats with subtotal splenectomy preserving the inferior pole

Acta Cirurgica Brasileira ◽

10.1590/s0102-86502011000300002 ◽

2011 ◽

Vol 26 (3) ◽

pp. 156-164 ◽

Cited By ~ 9

Author(s):

Marcela Souza Lima Paulo ◽

Isabel Cristina Andreatta Lemos Paulo ◽

Tarcizo Afonso Nunes ◽

Alcino Lázaro da Silva ◽

Luiz Cálice Cintra ◽

...

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Wistar Rats ◽

Oxygen Therapy ◽

Inferior Pole ◽

Group A ◽

Group B ◽

Oxygen Group ◽

Subtotal Splenectomy

PURPOSE: To evaluate the effect of hyperbaric oxygen therapy on the survival and weight of rats submitted to subtotal splenectomy and on the viability and growth of the inferior pole. METHODS: Forty Wistar rats underwent subtotal splenectomy with preservation of the inferior pole and distributed into two groups: Group A (n=20) - not treated with hyperbaric oxygen, Group B (n=20) - treated with hyperbaric oxygen. These groups were divided into two subgroups of 10 animals each, according to the time of euthanasia, 15th and 45th days. The survival and weight of the animals were recorded. The inferior pole was measured, weighed and morphologically analyzed. RESULTS: All animals survived. The weight of the animals increased in all subgroups, but decreased on the 10th day in the subgroups treated with hyperbaric oxygen (p<0.001). The viability of the inferior pole was more evident in animals treated on the 15th day, but did not differ on the 45th day. The growth of the inferior pole has not occurred on the 15th day but on the 45th day after surgery in untreated animals (p<0.01) and treated animals (p<0.05). Vascular and cellular increase in treated animals was significantly higher than in untreated ones. CONCLUSION: Hyperbaric oxygen therapy did not affect the survival of animals but reduced their weight. It improved the viability of the inferior splenic pole, but did not interfere with their growth.

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Hyperbaric Oxygen Therapy in Ischaemic Foot Ulcers in Type 2 Diabetes: A Clinical Trial

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192401812010080 ◽

2018 ◽

Vol 12 (1) ◽

pp. 80-85 ◽

Cited By ~ 6

Author(s):

Sarah Perren ◽

Alfred Gatt ◽

Nikolaos Papanas ◽

Cynthia Formosa

Keyword(s):

Type 2 Diabetes ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Foot Ulcer ◽

Treatment Modalities ◽

Foot Ulcers ◽

Ulcer Area ◽

Group A

Background and Aims: Several treatment modalities and protocols for ischaemic foot ulcers are available. However, little consensus exists on optimal treatment. The aim of this study was to compare Standard Wound Care (SWC) alone vs. SWC with adjunct hyperbaric oxygen therapy (HBOT) in the treatment of ischaemic Diabetic Foot Ulcers (DFUs). Patients and Methods: Twenty-six patients with Type 2 Diabetes Mellitus (T2DM) presenting with a newly diagnosed ischaemic foot ulcer were included. These were divided into group A (SWC with adjunct HBOT) and group B (SWC only). Participants were followed every week for 4 weeks and their ulcers were measured for their surface area and depth to assess any change in wound size. Results: Both treatment arms succeeded in reducing ulcer area and depth (p<0.001). However, ulcer area (p<0.001) and depth (p<0.001) exhibited superior improvement in group A. Conclusion : Adjunctive HBOT appears to improve wound healing in ischaemic DFUs and merits further study.

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