Remission Rate and Functional Outcomes During a 6-Month Treatment With Osmotic-Release Oral-System Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder

2015 ◽  
Vol 35 (5) ◽  
pp. 525-534 ◽  
Author(s):  
Yi Su ◽  
Haibo Li ◽  
Yixin Chen ◽  
Fang Fang ◽  
Tong Xu ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Functional Outcomes ◽  
Remission Rate ◽  
Hyperactivity Disorder

scholarly journals Adjuvant effects of vitamin A and vitamin D supplementation on treatment of children with attention-deficit/hyperactivity disorder: a study protocol for a randomised, double-blinded, placebo-controlled, multicentric trial in China

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e050541
Author(s):  
Ping Zhou ◽  
Mark Lee Wolraich ◽  
Ai-hua Cao ◽  
Fei-Yong Jia ◽  
Bin Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Attention Deficit Hyperactivity Disorder ◽  
Vitamin A ◽  
Attention Deficit ◽  
Remission Rate ◽  
Vitamin D Supplementation ◽  
Multicentric Study ◽  
Hyperactivity Disorder ◽  
Institutional Review ◽  
Double Blinded

IntroductionApproximately 7.2% of children in the world suffer from attention-deficit/hyperactivity disorder (ADHD). Due to the availability of the osmotic-release oral-system methylphenidate, ADHD currently has a remission rate of up to 30.72%. Nevertheless, it has been reported that patients with ADHD tend to exhibit vitamin A and vitamin D deficiency, which may aggravate the symptoms of ADHD. This study aims to determine the effect of vitamin A and vitamin D supplementation as adjunctive therapy to methylphenidate on the symptoms of ADHD.Methods and analysisThis is a parallel, prospective, interventional multicentric study. Patients will be enrolled from the southern, central and northern parts of China. A target of 504 patients will be followed for 8 weeks. They will be allocated into three groups (vitamin AD, vitamin D and placebo) and administered the interventions accordingly. Data on changes in the symptoms of ADHD as well as changes in the serum concentrations of vitamin A and vitamin D will be recorded. Both responders and nonresponders based on the sociodemographic and clinical data will also be described to mitigate selection bias.Ethics and disseminationThis study is performed in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of Children’s Hospital of Chongqing Medical University, China (approval number: (2019) IRB (STUDY) number 262). The results of the trial will be reported in peer-reviewed scientific journals and academic conferences regardless of the outcomes.Trial registration numberNCT04284059.

Methylphenidate Effects on Functional Outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)

2007 ◽  
Vol 17 (5) ◽  
pp. 581-592 ◽  
Author(s):  
Howard B. Abikoff ◽  
Benedetto Vitiello ◽  
Mark A. Riddle ◽  
Charles Cunningham ◽  
Laurence L. Greenhill ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Functional Outcomes ◽  
Hyperactivity Disorder ◽  
Disorder Treatment
Sign in / Sign up

Export Citation Format

Share Document