How medical treatment affects mean platelet volume as a cardiovascular risk marker in polycystic ovary syndrome?

2015 ◽  
Vol 26 (8) ◽  
pp. 862-865 ◽  
Author(s):  
Suna Kabil Kucur ◽  
Ilay Gozukara ◽  
Aysenur Aksoy ◽  
Eda U. Uludag ◽  
Havva Keskin ◽  
...  
2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110673
Author(s):  
Li Li ◽  
Jianxiu Yu ◽  
Zhongwei Zhou

Objective This meta-analysis evaluated the association between the mean platelet volume (MPV) and polycystic ovary syndrome (PCOS). Methods A systematic literature search using PubMed, EMBASE, and Web of Science databases until June 2021 was conducted. Pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were determined using a random effects model. Results Ten studies involving 866 women with PCOS and 548 age- and body mass index-matched women without PCOS were included. The MPV was significantly increased in women with PCOS compared with non-PCOS women (SMD = 0.43, 95% CI = 0.13–0.72). Subgroup analyses showed that this trend was consistent in cross-sectional studies (SMD = 0.44, 95% CI = 0.03–0.86) and in Turkish women (SMD = 0.46, 95% CI = 0.13–0.79). Meta-regression analysis revealed a marginally positive correlation between the MPV and the homoeostasis model assessment of insulin resistance in women with PCOS. The sensitivity analysis showed that the effect estimate was robust and stable, and publication bias was not evidenced in the pooled analysis. Conclusions This meta-analysis revealed that women with PCOS have a significantly increased MPV than women without PCOS, which is probably associated with insulin resistance. INPLASY registration number: INPLASY2021100021.


1969 ◽  
Vol 30 (3) ◽  
Author(s):  
Dilek Benk silfeler ◽  
Raziye Keskin kurt ◽  
Erhan Yengil ◽  
Burak Un ◽  
Secil Arica ◽  
...  

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