scholarly journals High Mortality of Cirrhotic Patients With End-Stage Renal Disease

Medicine ◽  
2016 ◽  
Vol 95 (10) ◽  
pp. e3057 ◽  
Author(s):  
Tsung-Hsing Hung ◽  
Chen-Chi Tsai ◽  
Kuo-Chih Tseng ◽  
Chih -Wei Tseng ◽  
Yu-Hsi Hsieh ◽  
...  
2017 ◽  
Vol 66 (4) ◽  
pp. 991-996 ◽  
Author(s):  
Nathan L. Liang ◽  
Theodore H. Yuo ◽  
Georges E. Al-Khoury ◽  
Eric S. Hager ◽  
Michel S. Makaroun ◽  
...  

2011 ◽  
Vol 76 (10) ◽  
pp. 306-313 ◽  
Author(s):  
S.-T. Huang ◽  
Y.-W. Chuang ◽  
C.-H. Cheng ◽  
M.-J. Wu ◽  
C.-H. Chen ◽  
...  

2008 ◽  
Vol 28 (2) ◽  
pp. 118-122 ◽  
Author(s):  
Rafael Selgas ◽  
M.-Auxiliadora Bajo ◽  
Gloria Del Peso ◽  
Rafael Sánchez-Villanueva ◽  
Elena Gonzalez ◽  
...  

The treatment of cirrhotic patients with ascites and end-stage renal disease is complex, due mainly to decreased effective arterial volume and hemodynamic instability. Peritoneal dialysis as a continuous therapy represents an alternative to hemodialysis-related intolerance. We report on our experience and that of others with cirrhotic patients with ascites treated by peritoneal dialysis. Hemodynamic tolerance was excellent in all patients and solute and water peritoneal transport increased to above the normal range in almost all cases. Morbidity and mortality were related principally to liver disease and other comorbidities. Peritoneal protein losses, initially high, decreased over time, maintaining serum albumin within the low normal range. The incidence of peritonitis was similar or slightly higher than usual in these patients, with peculiar etiology. The experiences with peritoneal dialysis suggest consideration of this treatment as the first choice for cirrhotic patients with ascites and that need to start dialysis.


2017 ◽  
Vol 37 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Mark A. Nader ◽  
Rodrigo Aguilar ◽  
Prabin Sharma ◽  
Parasuram Krishnamoorthy ◽  
Dragoi Serban ◽  
...  

BackgroundCirrhotic patients often develop end-stage renal disease (ESRD) requiring renal replacement therapy in the form of hemodialysis (HD) or peritoneal dialysis (PD). Studies comparing the outcomes and difference in in-hospital mortality between these 2 groups, particularly among those with ascites, are sparse. We set our objective to determine the dialysis modality with a better in-hospital survival rate among cirrhotic patients with ESRD (ESRD-cirrhosis).MethodsData was extracted from the 2005 to 2012 Nationwide Inpatient Sample (NIS). Using propensity score matching, ESRD-cirrhosis patients on PD were matched with patients on HD at a 1:1 ratio. Another subgroup analysis of ESRD-cirrhosis patients with ascites was performed using the same matching algorithm. Analyses were performed using SAS version 9.3 (SAS Institute, Cary, NC, USA).ResultsAmong 26,135 cirrhotic patients with incident ESRD, 25,686 (98.3%) and 449 (1.7%) were initiated on HD and PD, respectively, during the hospitalization. There was a nonsignificant mortality difference between the ESRD-cirrhosis patients treated with PD and those treated with HD. In a subgroup analysis of these patients with ascites, 18 patients underwent PD while 1,878 patients required HD. Also, PD had a significantly lower in-hospital mortality compared with HD in this subgroup (0% vs 26.67%, p = 0.03). Mean length of stay for those who received HD was 8.34 days compared with 7.06 days for the PD group ( p < 0.0001). Similarly, mean hospital charges were greater for those who had HD compared with PD ($74,501 vs $57,460; p < 0.001).ConclusionCirrhotic patients with ESRD and ascites who undergo PD have a significantly lower mortality than those who are started on HD. However PD is rarely initiated for ESRD in cirrhotic patients with ascites during hospitalization in the United States. Due to the potential advantages of PD, nephrologists should encourage PD when selecting dialysis modality in this subgroup of patients whenever possible.


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