scholarly journals Successful treatment of multisite hemorrhage by several methods in brain metastasis of choriocarcinoma

Medicine ◽  
2018 ◽  
Vol 97 (21) ◽  
pp. e10794 ◽  
Author(s):  
Zhen Ren ◽  
Li Yu ◽  
Mengnv Xie ◽  
Yiyi Liang ◽  
Fang Zhu ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Successful Treatment

scholarly journals Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

2015 ◽  
Vol 65 (1) ◽  
pp. 137-142
Author(s):  
PINCZOWSKI Pedro ◽  
GIMENO Marina ◽  
ACEÑA Carmen ◽  
VILLEGAS Ainara ◽  
de MARTINO Alba ◽  
...  
Keyword(s):  
Brain Metastasis ◽  
Brain Metastases ◽  
Blood Brain Barrier ◽  
Successful Treatment ◽  
Rare Event ◽  
Brain Barrier ◽  
Splenic Metastasis ◽  
Vincristine Sulfate ◽  
S 100 ◽  
The Brain

Abstract A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.

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