Role of the gut–skin axis in IgE-mediated food allergy and atopic diseases

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Noor Hidayatul Aini Suaini ◽  
Kewin Tien Ho Siah ◽  
Elizabeth Huiwen Tham
Keyword(s):  
Food Allergy ◽  
Atopic Diseases ◽  
Ige Mediated

Non-IgE Mediated Food Allergy

2020 ◽  
Vol 16 (2) ◽  
pp. 95-105
Author(s):  
Antonella Cianferoni
Keyword(s):  
Food Allergy ◽  
Eosinophilic Esophagitis ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Food Protein ◽  
Ige Mediated ◽  
Food Challenges ◽  
Allergic Proctocolitis ◽  
Eosinophilic Disorders

Food allergies, defined as an immune response to food proteins, affect as many as 8% of young children and 2% of adults in western countries, and their prevalence appears to be rising like all allergic diseases. In addition to well-recognized urticaria and anaphylaxis triggered by IgE antibody– mediated immune responses, there is an increasing recognition of cell-mediated disorders, such as eosinophilic esophagitis and food protein–induced enterocolitis. Non-IgE-Mediated gastrointestinal food allergies are a heterogeneous group of food allergies in which there is an immune reaction against food but the primary pathogenesis is not a production of IgE and activation of mast cells and basophils. Those diseases tend to affect mainly the gastrointestinal tract and can present as acute (FPIES) or chronic reaction, such as Eosinophilic Esophagitis (EoE), Food Protein-Induced Allergic Proctocolitis (FPIAP). The role of food allergy in Non-EoE gastrointestinal Eosinophilic disorders (Non- EoE EGID) is poorly understood. In some diseases like EoE, T cell seems to play a major role in initiating the immunological reaction against food, however, in FPIES and FPIAP, the mechanism of sensitization is not clear. Diagnosis requires food challenges and/or endoscopies in most of the patients, as there are no validated biomarkers that can be used for monitoring or diagnosis of Non-IgE mediated food allergies. The treatment of Non-IgE food allergy is dependent on diet (FPIES, and EoE) and/or use of drugs (i.e. steroids, PPI) in EoE and Non-EoE EGID. Non-IgE mediated food allergies are being being investigated.

The role of dietary interventions in the prevention of IgE-mediated food allergy in children

2017 ◽  
Vol 28 (3) ◽  
pp. 222-229 ◽  
Author(s):  
George Du Toit ◽  
Ru-Xin Foong ◽  
Gideon Lack
Keyword(s):  
Food Allergy ◽  
Dietary Interventions ◽  
Ige Mediated

scholarly journals Food Allergy Prevention and Management in Children

2021 ◽  
Vol 3 (2) ◽  
pp. 080-086
Author(s):  
Melike YILDIZ ◽  
Gülcan ARUSOĞLU
Keyword(s):  
Food Allergy ◽  
Treatment Strategies ◽  
Public Health Problem ◽  
Epidemiological Data ◽  
Allergy Prevention ◽  
Important Public Health Problem ◽  
Immunological Mechanisms ◽  
Ige Mediated ◽  
Personalized Approach

Food allergy is a reaction mediated by immunological mechanisms that cause various symptoms in susceptible individuals while harmless in individuals who are not sensitive to the specific allergen. The reactions that take place are divided into three: IgE-mediated reactions, non-IgE-mediated reactions, and mixed-type reactions. While many types of food have the potential to cause allergen reactions, fewer foods are responsible for the most clinically severe reactions and for the majority of reported cases. Food allergy, which is increasingly common worldwide, is becoming an important public health problem. Although there are no clear epidemiological data, the prevalence of food allergy varies between 6-10% in preschool children and decreases to 2-5% in adulthood. Food allergy has long been recognized as a pediatric disease, as most cases tend to begin in childhood and disappear with growth. There is increasing evidence to support the role of early administration of potential food allergens to prevent food allergy. The management process of food allergy cases includes plans and innovative treatment strategies aimed at a personalized approach.

The role of the gastroenterologist in non-IgE mediated gastrointestinal food allergy

2016 ◽  
Vol 26 (10) ◽  
pp. 445-450
Author(s):  
Ru-Xin Foong ◽  
Helen A. Brough ◽  
Adriana Chebar Lozinsky ◽  
Neil Shah
Keyword(s):  
Food Allergy ◽  
Ige Mediated ◽  
Gastrointestinal Food Allergy

Non-IgE Mediated Food Allergy

2020 ◽  
Vol 16 (2) ◽  
pp. 95-105
Author(s):  
Antonella Cianferoni
Keyword(s):  
Food Allergy ◽  
Eosinophilic Esophagitis ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Food Protein ◽  
Ige Mediated ◽  
Food Challenges ◽  
Allergic Proctocolitis ◽  
Eosinophilic Disorders

: Food allergies, defined as an immune response to food proteins, affect as many as 8% of young children and 2% of adults in western countries, and their prevalence appears to be rising like all allergic diseases. In addition to well-recognized urticaria and anaphylaxis triggered by IgE antibody– mediated immune responses, there is an increasing recognition of cell-mediated disorders, such as eosinophilic esophagitis and food protein–induced enterocolitis. Non-IgE-Mediated gastrointestinal food allergies are a heterogeneous group of food allergies in which there is an immune reaction against food but the primary pathogenesis is not a production of IgE and activation of mast cells and basophils. : Those diseases tend to affect mainly the gastrointestinal tract and can present as acute (FPIES) or chronic reaction, such as Eosinophilic Esophagitis (EoE), Food Protein-Induced Allergic Proctocolitis (FPIAP). The role of food allergy in Non-EoE gastrointestinal Eosinophilic disorders (Non- EoE EGID) is poorly understood. : In some diseases like EoE, T cell seems to play a major role in initiating the immunological reaction against food, however, in FPIES and FPIAP, the mechanism of sensitization is not clear. : Diagnosis requires food challenges and/or endoscopies in most of the patients, as there are no validated biomarkers that can be used for monitoring or diagnosis of Non-IgE mediated food allergies. : The treatment of Non-IgE food allergy is dependent on diet (FPIES, and EoE) and/or use of drugs (i.e. steroids, PPI) in EoE and Non-EoE EGID. : Non-IgE mediated food allergies are being being investigated.

scholarly journals Eosinophilic Esophagitis: Association with atopic diseases and IgE mediated Food Allergy

2019 ◽  
Vol 143 (2) ◽  
pp. AB140
Author(s):  
Pablo Torres ◽  
Andressa Zanandrea ◽  
Antonio Penido ◽  
Catherine Sonaly Ferreira Martins ◽  
Claudia Castilho Mouco ◽  
...  
Keyword(s):  
Food Allergy ◽  
Eosinophilic Esophagitis ◽  
Atopic Diseases ◽  
Ige Mediated

scholarly journals Pertussis immunisation in infancy and atopic outcomes: A protocol for a population-based cohort study using linked administrative data

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0260388
Author(s):  
Gladymar Pérez Chacón ◽  
Parveen Fathima ◽  
Mark Jones ◽  
Rosanne Barnes ◽  
Peter C. Richmond ◽  
...  
Keyword(s):  
Food Allergy ◽  
Pertussis Vaccine ◽  
Recurrent Events ◽  
Hospital Admissions ◽  
Population Based ◽  
Noncommunicable Diseases ◽  
Linkage Data ◽  
Atopic Diseases ◽  
Whole Cell ◽  
Ige Mediated

Introduction The burden of IgE-mediated food allergy in Australian born children is reported to be among the highest globally. This illness shares risk factors and frequently coexists with asthma, one of the most common noncommunicable diseases of childhood. Findings from a case-control study suggest that compared to immunisation with acellular pertussis vaccine, early priming of infants with whole-cell pertussis vaccine may be associated with a lower risk of subsequent IgE-mediated food allergy. If whole-cell vaccination is protective of food allergy and other atopic diseases, especially if protective against childhood asthma, the population-level effects could justify its preferential recommendation. However, the potential beneficial effects of whole-cell pertussis vaccination for the prevention of atopic diseases at a population-scale are yet to be investigated. Methods and analysis Analyses of population-based record linkage data will be undertaken to compare the rates of admissions to hospital for asthma in children aged between 5 and 15 years old, who were born in Western Australia (WA) or New South Wales (NSW) between 1997 and 1999 (329,831) when pertussis immunisation in Australia transitioned from whole-cell to acellular only schedules. In the primary analysis we will estimate hazard ratios and 95% confidence intervals for the time-to-first-event (hospital admissions as above) using Cox proportional hazard models in recipients of a first dose of whole-cell versus acellular pertussis-containing vaccine before 112 days old (~4 months of age). Similarly, we will also fit time-to-recurrent events analyses using Andersen-Gill models, and robust variance estimates to account for potential within-child dependence. Hospitalisations for all-cause anaphylaxis, food anaphylaxis, venom, all-cause urticaria and atopic dermatitis will also be examined in children who received at least one dose of pertussis-containing vaccine by the time of the cohort entry, using analogous statistical methods. Presentations to the emergency departments will be assessed separately using the same statistical approach.

scholarly journals Sex Disparity in Food Allergy: Evidence from the PubMed Database

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Caleb Kelly ◽  
Venu Gangur
Keyword(s):  
Food Allergy ◽  
Food Allergies ◽  
Female Ratio ◽  
Immune Mediated ◽  
Pubmed Database ◽  
Male Female Ratio ◽  
Ige Mediated ◽  
Sex Disparity ◽  
The Relationship

Food allergies are potentially fatal immune-mediated disorders that are growing globally. The relationship between sex and food allergy remains incompletely understood. Here we tested the hypothesis that, should sex influence the clinical response to food allergens, this would be reflected by a sex disparity in published studies of food allergy. We performed a systematic search of the PubMed literature for IgE-mediated allergy to 11 allergenic foods of international regulatory importance. No date restriction was used and only articles in English were considered. Of the 4744 articles retrieved, 591 met the inclusion criteria representing 17528 subjects with food allergies. Whereas among children with food allergies, 64.35% were males and 35.65% were females (male/female ratio, 1.80), among adults 34.82% were males and 65.18% were females (male/female ratio, 0.53). Consequently, these data argue that there is need for further investigation to define the role of sex in the pathogenesis of food allergy.

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