Nodular Lymphocyte-predominant Hodgkin Lymphoma Presenting as Fulminant Hepatic Failure in a Pediatric Patient: A Case Report With Pathologic, Immunophenotypic, and Molecular Findings

2008 ◽  
Vol 16 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Kirsten M. W. Woolf ◽  
Michael C. Wei ◽  
Michael P. Link ◽  
Daniel A. Arber ◽  
Roger A. Warnke
Keyword(s):  
Case Report ◽  
Hodgkin Lymphoma ◽  
Pediatric Patient ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure

A successful initiation of treatment of Hodgkin's lymphoma with adriamycin-bleomycin-vinblastine-dacarbazine dose reduction in a patient with fulminant hepatic failure and co-infection with human immunodeficiency virus and hepatitis B

2021 ◽  
pp. 107815522110401
Author(s):  
Sindhusha Veeraballi ◽  
Kok H Chan ◽  
Jihad Slim ◽  
Hamid S Shaaban ◽  
Gunwant Guron
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Survival Rate ◽  
Hepatitis B ◽  
Hodgkin Lymphoma ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Hepatic Function ◽  
Full Dose ◽  
Immunodeficiency Virus

Introduction Hodgkin lymphoma is a highly curable lymphoproliferative malignancy with an overall relative survival rate of 87.4%. It is characterized by multinucleated Reed–Sternberg cells which are mostly derived from B cells in the germinal center. Case report We present a case of a 40-year-old gentleman with acquired immunodeficiency syndrome who presented with Stage 4b Hodgkin lymphoma complicated with fulminant hepatic failure and direct hyperbilirubinemia. The initial presentation of Hodgkin lymphoma as cholestatic jaundice is extremely rare. Management and outcome Though the survival rate with chemotherapy is high, the fulminant hepatic failure made the situation challenging with the use of chemotherapeutic regimens that require hepatic excretion. He received dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen [doxorubicin 12.5 mg (6.75 mg/m2), bleomycin 18 units (10 units/m2), vinblastine 3 mg (1.5 mg/m2), dacarbazine 380 mg (190 mg/m2)] as well as bictegravir/emtricitabine/tenofovir alafenamide since admission for treatment of human immunodeficiency virus and hepatitis B. He started responding with the first cycle of dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen with bilirubin levels trended down and normalized as well as his clinical condition improved. He received the full dose of adriamycin-bleomycin-vinblastine-dacarbazine on day 15. Discussion Our case report emphasizes that the early usage of dose reduced adriamycin-bleomycin-vinblastine-dacarbazine regimen can restore hepatic function and can achieve improvement in hepatic function allowing the delivery of full-dose chemotherapy.

Fulminant Hepatic Failure After Open Heart Surgery: A Case Report

1984 ◽  
Vol 18 (3) ◽  
pp. 185-188
Author(s):  
Yasuo Morishita ◽  
Akira Taira
Keyword(s):  
Case Report ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Hodgkin lymphoma and fulminant hepatic failure

2010 ◽  
Vol 51 (5) ◽  
pp. 947-951 ◽  
Author(s):  
Frank S. Hong ◽  
Carole L. Smith ◽  
Peter W. Angus ◽  
Peter Crowley ◽  
Wai Khoon Ho
Keyword(s):  
Hodgkin Lymphoma ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure

Case Report: Fulminant Hepatic Failure Involving Duloxetine Hydrochloride

2006 ◽  
Vol 4 (7) ◽  
pp. 912-917 ◽  
Author(s):  
A. James Hanje ◽  
Lindsay J. Pell ◽  
Nicholas A. Votolato ◽  
Wendy L. Frankel ◽  
Robert B. Kirkpatrick
Keyword(s):  
Case Report ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Duloxetine Hydrochloride

Fulminant hepatic failure after repeated exposure to isoflurane anesthesia: A case report

Hepatology ◽  
1991 ◽  
Vol 13 (6) ◽  
pp. 1017-1021 ◽  
Author(s):  
Elizabeth M. Brunt ◽  
Heather White ◽  
J. Wallis Marsh ◽  
Barbel Holtmann ◽  
Marion G. Peters
Keyword(s):  
Case Report ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Repeated Exposure ◽  
Isoflurane Anesthesia
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