Prognostic Significance of “Nonsolid” Microscopic Metastasis in Merkel Cell Carcinoma Sentinel Lymph Nodes

2019 ◽  
Vol 43 (7) ◽  
pp. 907-919 ◽  
Author(s):  
Emily M. Erstine ◽  
Michael T. Tetzlaff ◽  
Xuefei Jia ◽  
Phyu P. Aung ◽  
Victor G. Prieto ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Prognostic Significance ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

scholarly journals Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Cancer ◽  
2001 ◽  
Vol 92 (6) ◽  
pp. 1650-1655 ◽  
Author(s):  
Peter J. Allen ◽  
Klaus Busam ◽  
Arnold D. K. Hill ◽  
Alexander Stojadinovic ◽  
Daniel G. Coit
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immunohistochemical Analysis ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

scholarly journals Detection of Merkel cell virus and correlation with histologic presence of Merkel cell carcinoma in sentinel lymph nodes

2012 ◽  
Vol 106 (7) ◽  
pp. 1314-1319 ◽  
Author(s):  
M Loyo ◽  
J Schussel ◽  
E Colantuoni ◽  
J Califano ◽  
M Brait ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Sentinel Lymph Nodes ◽  
Merkel Cell

Immunostaining for cytokeratin 20 improves detection of micrometastatic Merkel cell carcinoma in sentinel lymph nodes

2002 ◽  
Vol 46 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Lyndon D. Su ◽  
Lori Lowe ◽  
Carol R. Bradford ◽  
Alan I. Yahanda ◽  
Timothy M. Johnson ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Sentinel Lymph Nodes ◽  
Cytokeratin 20 ◽  
Merkel Cell

Differentiating Merkel cell carcinoma of lymph nodes without a detectable primary skin tumor from other metastatic neuroendocrine carcinomas: The ELECTHIP criteria

2018 ◽  
Vol 78 (5) ◽  
pp. 964-972.e3 ◽  
Author(s):  
Thibault Kervarrec ◽  
Julia Zaragoza ◽  
Pauline Gaboriaud ◽  
Amélie Le Gouge ◽  
Agnès Beby-Defaux ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Skin Tumor ◽  
Merkel Cell ◽  
Neuroendocrine Carcinomas

scholarly journals Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Loren Masterson ◽  
Bryan J. Thibodeau ◽  
Laura E. Fortier ◽  
Timothy J. Geddes ◽  
Barbara L. Pruetz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Rna Isolation ◽  
Merkel Cell ◽  
Mucin 1 ◽  
Neurofilament Protein ◽  
Significant Differential Expression

Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical. This study aimed to identify biomarkers with prognostic significance. While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study. Patients were stratified into good, moderate, or poor prognosis. Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays. Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis. Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors. In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, andKITwere upregulated in specimens from patients with poor prognosis. Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients.

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