Basaloid Squamous Cell Carcinoma of the Esophagus: Assessment for High-risk Human Papillomavirus and Related Molecular Markers

Basaloid squamous cell carcinoma is an infiltrative and aggressive variant of squamous cell carcinoma with basaloid features. Primary skin-derived basaloid squamous cell carcinoma is rare. Basaloid squamous cell carcinoma is commonly observed in the oropharyngeal and anogenital regions and is associated with high-risk human papillomavirus. We report a case of primary basaloid squamous cell carcinoma overlying the right scapula with metastasis to the regional lymph nodes and brain despite surgical resection and adjuvant chemoradiation. Histopathologic investigations of high-risk cutaneous squamous cell carcinoma do not routinely involve human papillomavirus testing. In contrast, oncogenic human papillomavirus and p16 are screened in head and neck squamous cell carcinoma for prognostication. Since the patient presented with an aggressive variant of squamous cell carcinoma and distal metastasis despite standard therapies, human papillomavirus testing was performed. P16, a surrogate marker for human papillomavirus infection and specifically HPV16 was identified in the tumor. This is a unique report of HPV16 in primary cutaneous basaloid squamous cell carcinoma with distal brain metastasis.

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Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus

Diseases of the Esophagus ◽

10.1093/dote/dox076 ◽

2017 ◽

Vol 30 (12) ◽

pp. 1-5

Author(s):

J. Oguma ◽

S. Ozawa ◽

A. Kazuno ◽

M. Nitta ◽

Y. Ninomiya ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Basaloid Squamous Cell Carcinoma ◽

Carcinoma Of The Esophagus ◽

Basaloid Squamous

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Surgical Resection of a Solitary Pulmonary Metastasis from Basaloid Squamous Cell Carcinoma of the Esophagus: A Case Report

Annals of Thoracic and Cardiovascular Surgery ◽

10.5761/atcs.cr.13-00100 ◽

2014 ◽

Vol 20 (Supplement) ◽

pp. 646-649 ◽

Cited By ~ 3

Author(s):

Takayuki Kosaka ◽

Akira Mogi ◽

Ei Yamaki ◽

Tatsuya Miyazaki ◽

Hiroyuki Kuwano

Keyword(s):

Squamous Cell Carcinoma ◽

Case Report ◽

Cell Carcinoma ◽

Surgical Resection ◽

Pulmonary Metastasis ◽

Squamous Cell ◽

Basaloid Squamous Cell Carcinoma ◽

Carcinoma Of The Esophagus ◽

Basaloid Squamous

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Basaloid Squamous Cell Carcinoma of the Esophagus a Case Report

Tumori Journal ◽

10.1177/030089160509100118 ◽

2005 ◽

Vol 91 (1) ◽

pp. 87-89 ◽

Cited By ~ 1

Author(s):

Miroslav Bekavac-Bešlin ◽

August Mijić ◽

Aljoša Matejčić ◽

Željko Ferenčić

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Undifferentiated Carcinoma ◽

Endoscopic Biopsy ◽

Esophageal Wall ◽

Basaloid Squamous Cell Carcinoma ◽

Surgical Specimen ◽

Carcinoma Of The Esophagus ◽

Basaloid Squamous

Basaloid squamous cell carcinoma (BSCC) of the esophagus is an extremely rare tumor which should be differentiated from adenoid cystic and small cell undifferentiated carcinoma. We present the case of a 48-year-old male patient with esophageal BSCC. This tumor has specific histological features which may be difficult to recognize by small endoscopic biopsy examination. In our patient the surgical specimen revealed BSCC with an aggressive pattern (invasion of the whole esophageal wall thickness, lymph node metastases and intraneural spread). We proposed chemotherapy and radiotherapy after surgery, which resulted in a survival of 17 months.

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A Case of Basaloid Squamous Cell Carcinoma of Polypoid Type in the Esophagus

Case Reports in Gastroenterology ◽

10.1159/000479312 ◽

2017 ◽

Vol 11 (3) ◽

pp. 559-563

Author(s):

Ki Hun Lee ◽

Sang Jin Lee ◽

Hak Soo Kim ◽

Sung Eun Kim ◽

Soo Yong Choi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Endoscopic Examination ◽

Basaloid Squamous Cell Carcinoma ◽

Polypoid Mass ◽

Carcinoma Of The Esophagus ◽

Ivor Lewis ◽

Basaloid Squamous

Basaloid squamous cell carcinoma of the esophagus is very rare. Further, polypoid type of esophageal cancer is also rare. We have recently treated a case of basaloid squamous cell carcinoma which presented as a 1.3-cm esophageal polyp. A 48-year-old woman was referred to our hospital because of a polypoid mass at 36 cm distance from the upper incisor on endoscopic examination, and the result of the biopsy was basaloid squamous cell carcinoma. The patient underwent Ivor Lewis operation with lymph node dissection. Two basaloid squamous cell carcinomas, of 1.3 and 0.4 cm, were diagnosed in the final pathologic examination. Regular periodic follow-up showed no evidence of recurrence or metastasis in the 5-month postoperative period.

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