Quantitative Apparent Diffusion Coefficient as a Noninvasive Imaging Biomarker for the Differentiation of Invasive Breast Cancer and Ductal Carcinoma In Situ

We present a case of ductal carcinoma in situ within a fibroadenoma. Breast cancer arising within fibroadenoma incidence ranges from 0.125% to 0.02%, and ductal carcinoma in situ is not the most frequent malignancy that can be found within a fibroadenoma. Dynamic contrast-enhanced magnetic resonance imaging showed an oval mass with circumscribed margins and dark internal septations, suspicious for fibroadenoma. According to European Society of Breast Radiology diffusion-weighted imaging consensus, mean apparent diffusion coefficient value obtained by drawing a small region of interest on the lesion apparent diffusion coefficient map showed a low diffusion level. Therefore, ductal carcinoma in situ within a fibroadenoma was diagnosed at final pathology after surgical excision.

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Evaluation of Apparent Diffusion Coefficient to Predict Grade, Microinvasion, and Invasion in Ductal Carcinoma In Situ of the Breast

Academic Radiology ◽

10.1016/j.acra.2015.08.004 ◽

2015 ◽

Vol 22 (12) ◽

pp. 1483-1488 ◽

Cited By ~ 10

Author(s):

Heba Hussein ◽

Caroline Chung ◽

Hadas Moshonov ◽

Naomi Miller ◽

Supriya R. Kulkarni ◽

...

Keyword(s):

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Apparent Diffusion

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Detection of invasive components in cases of breast ductal carcinoma in situ on biopsy by using apparent diffusion coefficient MR parameters

European Radiology ◽

10.1007/s00330-013-2902-2 ◽

2013 ◽

Vol 23 (10) ◽

pp. 2705-2712 ◽

Cited By ~ 36

Author(s):

Naoko Mori ◽

Hideki Ota ◽

Shunji Mugikura ◽

Chiaki Takasawa ◽

Junya Tominaga ◽

...

Keyword(s):

Diffusion Coefficient ◽

Apparent Diffusion Coefficient ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Apparent Diffusion

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Risk stratification of ductal carcinoma in situ using whole-lesion histogram analysis of the apparent diffusion coefficient

European Radiology ◽

10.1007/s00330-018-5666-x ◽

2018 ◽

Vol 29 (2) ◽

pp. 485-493 ◽

Cited By ~ 6

Author(s):

Jin You Kim ◽

Jin Joo Kim ◽

Ji Won Lee ◽

Nam Kyung Lee ◽

Geewon Lee ◽

...

Keyword(s):

Diffusion Coefficient ◽

Risk Stratification ◽

Apparent Diffusion Coefficient ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Histogram Analysis ◽

Apparent Diffusion

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22. Invasive breast cancer after a diagnosis of ductal carcinoma in situ: does mode of presentation influence recurrence risk?

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2014.02.212 ◽

2014 ◽

Vol 40 (5) ◽

pp. 607

Author(s):

Shan Cheung ◽

Mary Booth ◽

David Dodwell

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma In Situ ◽

Invasive Breast Cancer ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Recurrence Risk ◽

Mode Of Presentation

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Subsequent risk of ipsilateral and contralateral invasive breast cancer after treatment for ductal carcinoma in situ: incidence and the effect of radiotherapy in a population-based cohort of 10,090 women

Breast Cancer Research and Treatment ◽

10.1007/s10549-016-3973-y ◽

2016 ◽

Vol 159 (3) ◽

pp. 553-563 ◽

Cited By ~ 20

Author(s):

Lotte E. Elshof ◽

Michael Schaapveld ◽

Marjanka K. Schmidt ◽

Emiel J. Rutgers ◽

Flora E. van Leeuwen ◽

...

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma In Situ ◽

Invasive Breast Cancer ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Population Based ◽

Subsequent Risk

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2–12 Incidence of Invasive Breast Cancer and Ductal Carcinoma In Situ in a Screening Program by Age: Should Older Women Continue Screening?

Breast Diseases A Year Book Quarterly ◽

10.1016/s1043-321x(05)80104-3 ◽

2005 ◽

Vol 16 (2) ◽

pp. 145-146

Author(s):

R.J. Brenner

Keyword(s):

Breast Cancer ◽

Older Women ◽

Ductal Carcinoma In Situ ◽

Invasive Breast Cancer ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Screening Program

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Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer

ISRN Oncology ◽

10.5402/2011/673790 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Andrei Dobrescu ◽

Monique Chang ◽

Vatsala Kirtani ◽

George K. Turi ◽

Randa Hennawy ◽

...

Keyword(s):

Breast Cancer ◽

Ductal Carcinoma In Situ ◽

Invasive Breast Cancer ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Receptor Expression ◽

Invasive Cancer ◽

Positive Staining ◽

Receptor Status

Background. To our knowledge, the hormone receptor status of noncontiguous ductal carcinoma in situ (DCIS) occurring concurrently in ER/PgR-negative invasive cancer has not been studied. The current study was undertaken to investigate the ER/PgR receptor status of DCIS of the breast in patients with ER/PgR-negative invasive breast cancer. Methods. We reviewed the immunohistochemical (IHC) staining for ER and PgR of 187 consecutive cases of ER/PgR-negative invasive breast cancers, collected from 1995 to 2002. To meet the criteria for the study, we evaluated ER/PgR expression of DCIS cancer outside of the invasive breast cancer. Results. A total of 37 cases of DCIS meeting the above criteria were identified. Of these, 16 cases (43.2%) showed positive staining for ER, PgR, or both. Conclusions. In our study of ER/PgR-negative invasive breast cancer we found that in 8% of cases noncontiguous ER/PR-positive DCIS was present. In light of this finding, it may be important for pathologists to evaluate the ER/PgR status of DCIS occurring in the presence of ER/PgR-negative invasive cancer, as this subgroup could be considered for chemoprevention.

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