ADMINISTRATION OF VALPROIC ACID IN CLINICALLY APPROVED DOSE IMPROVES NEUROLOGIC RECOVERY AND DECREASES BRAIN LESION SIZE IN SWINE SUBJECTED TO HEMORRHAGIC SHOCK AND TRAUMATIC BRAIN INJURY

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Glenn K. Wakam ◽  
Ben E. Biesterveld ◽  
Manjunath P. Pai ◽  
Michael T. Kemp ◽  
Rachel L. O’Connell ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Brain Lesion ◽  
Lesion Size ◽  
Neurologic Recovery

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma

2017 ◽  
Vol 83 (6) ◽  
pp. 1066-1073 ◽  
Author(s):  
Vahagn C. Nikolian ◽  
Patrick E. Georgoff ◽  
Manjunath P. Pai ◽  
Isabel S. Dennahy ◽  
Kiril Chtraklin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Brain Lesion ◽  
Lesion Size ◽  
Neurologic Recovery

A Single Dose of Valproic Acid Improves Neurologic Recovery and Decreases Brain Lesion Size in Swine Subjected to an Isolated Traumatic Brain Injury

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Glenn K. Wakam ◽  
Ben E. Biesterveld ◽  
Manjunath P. Pai ◽  
Michael T. Kemp ◽  
Rachel L. O’Connell ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Single Dose ◽  
Brain Injury ◽  
Brain Lesion ◽  
Lesion Size ◽  
Neurologic Recovery

scholarly journals Modeling traumatic brain injury combined with hemorrhagic shock in rats: Neurological assessment and PET imaging with 18F-fluorodeoxyglucaric acid

2021 ◽  
Author(s):  
Hibah O Awwad ◽  
Andria Hedrick ◽  
Alex Mdzinarishvili ◽  
Hailey Houson ◽  
Kelly Standifer ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Tissue Injury ◽  
Brain Lesion ◽  
Lesion Size ◽  
Neurological Deficits ◽  
Lesion Volume ◽  
Sprague Dawley ◽  
The Impact

Traumatic brain injury (TBI)is a major cause of death and disability worldwide. Hemorrhagic shock (HS) aggravates tissue injury and complicates TBI recovery. We studied the combined insult of mild TBI and HS and investigated the impact of varying loss of blood volume on neurologic deficit and brain lesion volume. A novel positron emission tomography (PET) technique was employed to monitor tissue injury. Male Sprague Dawley rats received mTBI by controlled cortical impact (CCI) followed by withdrawal of 0%, 30-40%, 45%, or 50% of blood (mTBI, mTBI+HS≤40%, mTBI+HS45%, and mTBI+HS50%, respectively). Neurological deficit (mNSS= 5.6, 7.6, and 12.3) and mortality (2/12, 2/6, and 7/12) were higher in mTBI+HS≤40%, mTBI+HS45%, and mTBI+HS50%, than in mTBI alone rats (no death; mNSS=3.3). Histologic lesion size increased 3.5-fold in mTBI+HS50% compared to mTBI alone and the infarct-avid PET agent 18F-fluorodeoxyglucaric acid (FGA) proportionately detected tissue necrosis in mTBI+HS50% rats. Based on these results, we conclude that HS aggravates mTBI-induced neurological deficits, tissue injury and mortality. PET using 18F-FGA as an imaging marker can detect the extent of injury in a non-invasive manner.

Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock

2018 ◽  
Vol 228 ◽  
pp. 84-92 ◽  
Author(s):  
Michael Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Gerald A. Higgins ◽  
Patrick E. Georgoff ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Porcine Model

Valproic acid increases endothelial glycocalyx shedding and decreases lesion size volume in a rodent model of severe isolated traumatic brain injury

2013 ◽  
Vol 217 (3) ◽  
pp. S32 ◽  
Author(s):  
Cecilie H. Jepsen ◽  
Pär I. Johansson ◽  
Anders Perner ◽  
Martin H. Sillesen ◽  
Hasan B. Alam ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Lesion Size ◽  
Rodent Model ◽  
Endothelial Glycocalyx

Effect of valproic acid and injury on lesion size and endothelial glycocalyx shedding in a rodent model of isolated traumatic brain injury

2014 ◽  
Vol 77 (2) ◽  
pp. 292-297 ◽  
Author(s):  
Cecilie Heerdegen Jepsen ◽  
Marc A. deMoya ◽  
Anders Perner ◽  
Martin Sillesen ◽  
Sisse R. Ostrowski ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Lesion Size ◽  
Rodent Model ◽  
Endothelial Glycocalyx

Valproic Acid Treatment Rapidly Modulates the Proteomic Profile in a Porcine Model of Hemorrhagic Shock and Traumatic Brain Injury

2017 ◽  
Vol 225 (4) ◽  
pp. S67
Author(s):  
Michael B. Weykamp ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Patrick E. Georgoff ◽  
Gerry A. Higgins ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment ◽  
Porcine Model ◽  
Proteomic Profile

Valproic Acid Treatment Modulates the Inflammatory and Coagulation Proteome Following Traumatic Brain Injury and Hemorrhagic Shock

2019 ◽  
Vol 229 (4) ◽  
pp. S313
Author(s):  
Umar F. Bhatti ◽  
Aaron M. Williams ◽  
Vahagn C. Nikolian ◽  
Isabel S. Dennahy ◽  
Michael Weykamp ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Valproic Acid ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Acid Treatment
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