scholarly journals Induced pluripotent stem cell therapies for retinal disease

2010 ◽  
Vol 23 (1) ◽  
pp. 4-9 ◽  
Author(s):  
Oliver Comyn ◽  
Edward Lee ◽  
Robert E MacLaren
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Retinal Disease ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Induced Pluripotent

Feasibility of Induced Pluripotent Stem Cell Therapies for Treatment of Type 1 Diabetes

2018 ◽  
Vol 24 (6) ◽  
pp. 482-492
Author(s):  
Caden Duffy ◽  
Cesar Prugue ◽  
Rachel Glew ◽  
Taryn Smith ◽  
Calvin Howell ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Induced Pluripotent

scholarly journals Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Zhihan Zhao ◽  
Huan Lan ◽  
Ibrahim El-Battrawy ◽  
Xin Li ◽  
Fanis Buljubasic ◽  
...  
Keyword(s):  
Stem Cell ◽  
Ion Channels ◽  
Ion Channel ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Biological Study ◽  
Adrenergic Stimulation ◽  
Cell Therapies ◽  
Channel Expression ◽  
Induced Pluripotent

Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. Methods. Cardiomyocytes were derived from hiPS cells that were generated from two healthy donors. qPCR and patch clamp techniques were used for the study. Results. In addition to the reported ion channels, INa, ICa-L, ICa-T, If, INCX, IK1, Ito, IKr, IKs IKATP, IK-pH, ISK1–3, and ISK4, we detected both the expression and currents of ACh-activated (KACh) and Na+-activated (KNa) K+, volume-regulated and calcium-activated (Cl-Ca) Cl−, and TRPV channels. All the detected ion currents except IK1, IKACh, ISK, IKNa, and TRPV1 currents contribute to AP duration. Isoprenaline increased ICa-L, If, and IKs but reduced INa and INCX, without an effect on Ito, IK1, ISK1–3, IKATP, IKr, ISK4, IKNa, ICl-Ca, and ITRPV1. Carbachol alone showed no effect on the tested ion channel currents. Conclusion. Our data demonstrate that most ion channels, which are present in healthy or diseased cardiomyocytes, exist in hiPSC-CMs. Some of them contribute to action potential performance and are regulated by adrenergic stimulation.

scholarly journals Autologous Induced Pluripotent Stem Cell–Based Cell Therapies: Promise, Progress, and Challenges

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Marinna Madrid ◽  
Cenk Sumen ◽  
Suvi Aivio ◽  
Nabiha Saklayen
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cell Therapies ◽  
Induced Pluripotent
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