The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorder: gene–environment interaction

AbstractWe utilized a longitudinal twin study (N = 2,510) to identify the child characteristics present prior to initiation of substance use that best predicted later substance use disorders. Two independent traits accounted for the majority of premorbid risk: socialization (conformity to rules and conventional values) and boldness (sociability and social assurance, stress resilience, and thrill seeking). Low socialization was associated with disruptive behavior disorders, parental externalizing disorders, and environmental adversity and exhibited moderate genetic (0.45) and shared environmental influences (0.30). Boldness was highly heritable (0.71) and associated with less internalizing distress and environmental adversity. In combination, these traits exhibited robust associations with adolescent and young adult substance use disorders (R = .48 and .50, respectively) and incremental prediction over disruptive behavior disorders, parental externalizing disorders, and environmental adversity. The results were replicated in an independent sample. Socialization and boldness offer a novel conceptualization of underlying risk for substance use disorders that has the potential to improve prediction and theory with implications for basic research, prevention, and intervention.

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Gene-Environment Interaction between the IL1RN Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17062036 ◽

2020 ◽

Vol 17 (6) ◽

pp. 2036

Author(s):

Yongzhao Shao ◽

Yian Zhang ◽

Mengling Liu ◽

Maria-Elena Fernandez-Beros ◽

Meng Qian ◽

...

Keyword(s):

Environmental Tobacco Smoke ◽

Tobacco Smoke ◽

Early Onset ◽

Adult Population ◽

Interleukin 1 ◽

Tobacco Smoke Exposure ◽

Environment Interaction ◽

Gene Environment Interaction ◽

Gene Environment ◽

Increased Risk

(1) Background: Variants of the interleukin-1 receptor antagonist (IL1RN) gene, encoding an anti-inflammatory cytokine, are associated with asthma. Asthma is a chronic inflammatory disease of the airway influenced by interactions between genetic variants and environmental factors. We discovered a gene–environment interaction (GEI) of IL1RN polymorphisms with childhood environmental tobacco smoke (ETS) exposure on asthma susceptibility in an urban adult population. (2) Methods: DNA samples from the NYU/Bellevue Asthma Registry were genotyped for tag SNPs in IL1RN in asthma cases and unrelated healthy controls. Logistic regressions were used to study the GEI between IL1RN variants and childhood ETS exposures on asthma and early onset asthma, respectively, adjusting for population admixture and other covariates. (3) Results: Whereas the rare genotypes of IL1RN SNPs (e.g., GG in SNP rs2234678) were associated with decreased risk for asthma among those without ETS exposure (odds ratio OR = 0.215, p = 0.021), they are associated with increased risk for early onset asthma among those with childhood ETS (OR = 4.467, p = 0.021). (4) Conclusions: We identified a GEI between polymorphisms of IL1RN and childhood ETS exposure in asthma. Analysis of GEI indicated that childhood ETS exposure disrupted the protective effect of some haplotypes/genotypes of IL1RN for asthma and turned them into high-risk polymorphisms for early onset asthma.

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Modular Treatment of Early-Onset Disruptive Behavior Disorders: Content, Outcomes, and Directions

PsycEXTRA Dataset ◽

10.1037/e634342009-001 ◽

2009 ◽

Author(s):

David Kolko

Keyword(s):

Disruptive Behavior ◽

Behavior Disorders ◽

Early Onset ◽

Disruptive Behavior Disorders ◽

Modular Treatment

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Genetic and Gene-Environment Influences on Disruptive Behavior Disorders

The Wiley Handbook of Disruptive and Impulse-Control Disorders ◽

10.1002/9781119092254.ch8 ◽

2017 ◽

pp. 125-141

Author(s):

Edward D. Barker ◽

Charlotte A. M. Cecil ◽

Esther Walton ◽

Alan J. Meehan

Keyword(s):

Disruptive Behavior ◽

Behavior Disorders ◽

Disruptive Behavior Disorders ◽

Gene Environment

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Antisocial peer affiliation and externalizing disorders: Evidence for Gene × Environment × Development interaction

Development and Psychopathology ◽

10.1017/s0954579416000109 ◽

2016 ◽

Vol 29 (1) ◽

pp. 155-172 ◽

Cited By ~ 15

Author(s):

Diana R. Samek ◽

Brian M. Hicks ◽

Margaret A. Keyes ◽

William G. Iacono ◽

Matt McGue

Keyword(s):

Substance Use ◽

Antisocial Behavior ◽

Substance Use Disorders ◽

Critical Period ◽

Externalizing Disorders ◽

Childhood And Adolescence ◽

Environment Interaction ◽

Peer Affiliation ◽

Gene Environment Interaction ◽

Gene Environment

AbstractGene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior.

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