Immunoglobulin class switch recombination: study through human natural mutants
2008 ◽
Vol 364
(1517)
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pp. 577-582
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Keyword(s):
Immunoglobulin class switch recombination deficiencies in humans are exquisite models to analyse the mechanisms of class switch recombination (CSR). Besides defects in CD40L/CD40 interaction, others result from an intrinsic B-cell deficiency. The recent elucidation of the molecular basis of some of them has made it possible to delineate the molecular events involved in antibody maturation. Activation-induced (cytidine) deaminase (AID) and uracil-N-glycosylase deficiencies have demonstrated the role of AID as the inducer of DNA lesions in switch and variable regions. However, most of these CSR deficiencies remain molecularly undefined. Their characterization would lead to a better understanding of the complex machinery involved in CSR.
2004 ◽
Vol 101
(35)
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pp. 13003-13007
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2003 ◽
Vol 171
(5)
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pp. 2504-2509
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2002 ◽
Vol 195
(9)
◽
pp. 1193-1198
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2003 ◽
Vol 100
(5)
◽
pp. 2634-2638
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2011 ◽
Vol 108
(28)
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pp. 11584-11589
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2003 ◽
Vol 987
(1)
◽
pp. 1-8
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