scholarly journals Effect of a Polyene Antibiotic on Growth and Phosphate Uptake by Candida albicans

1977 ◽  
Vol 102 (2) ◽  
pp. 299-304 ◽  
Author(s):  
I. BERDICEVSKY ◽  
N. GROSSOWICZ
Keyword(s):  
Candida Albicans ◽  
Phosphate Uptake ◽  
Polyene Antibiotic

Polyene antibiotic affinities for the sterols of resistant and sensitive strains of Neurospora crassa

1977 ◽  
Vol 23 (1) ◽  
pp. 113-115 ◽  
Author(s):  
D. Johnson ◽  
R. Subden
Keyword(s):  
Candida Albicans ◽  
Neurospora Crassa ◽  
Resistant Mutant ◽  
Wild Type ◽  
Polyene Antibiotic ◽  
Polyene Antibiotics ◽  
Mutant Strains ◽  
Resistant Strains

Ergosterol, the principle sterol of many wild-type Neurospora and other Ascomycetes, had a greater affinity for polyene antibiotics than did lichesterol or eburicol, the sterols of some resistant mutant strains. The affinity was demonstrated by comparing the sterols extracted from sensitive and resistant strains of Neurospora crassa and Candida albicans for protection against polyene inhibition of sensitive N. crassa and for their ability to alter specific polyene absorption maxima.

scholarly journals The Mode of Action of Polyene Antibiotics; Induced Entry of Hydrogen Ions as a Consequence of Polyene Action on the Cell Membrane of Candida albicans

Microbiology ◽  
2000 ◽  
Vol 81 (2) ◽  
pp. 331-336 ◽  
Author(s):  
S. M. HAMMOND ◽  
P. A. LAMBERT ◽  
B. N. KLIGER
Keyword(s):  
Candida Albicans ◽  
Cell Membrane ◽  
Electron Micrographs ◽  
Mode Of Action ◽  
Antifungal Agent ◽  
Hydrogen Ions ◽  
Polyene Antibiotic ◽  
Polyene Antibiotics ◽  
Selective Permeability ◽  
Degree Of Acidification

Summary: The polyene antibiotic candicidin is a potent antifungal agent acting upon the cell membrane of Candida albicans. Destruction of selective permeability by polyenes allows cations to leak into the environment and permits the entry of protons to neutralize the charge so created, causing internal acidification. Quantitive studies on proton entry reveal that K+ leakage alone is not sufficient to account for the degree of acidification recorded. Extracts of untreated C. albicans, when acidified to the same extent, precipitated. Electron micrographs of candicidin treated C. albicans cells confirm this precipitation.

Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic - resistant mutants of Candida albicans

1977 ◽  
Vol 23 (6) ◽  
pp. 751-754 ◽  
Author(s):  
R. E. Subden ◽  
L. Safe ◽  
D. C. Morris ◽  
R. G. Brown ◽  
S. Safe
Keyword(s):  
Candida Albicans ◽  
The Other ◽  
Wild Type ◽  
Polyene Antibiotic ◽  
Antibiotic Resistant ◽  
Resistant Mutants ◽  
Antibiotic Resistant Mutants

Two classes of polyene-resistant mutants were isolated from survivors of N-methyl-N′- nitro-N-nitrosoguanidine treatment of a wild-type Candida albicans. An analysis of the major sterols of one class revealed an accumulation of lichesterol and fecosterol while the other class accumulated eburicol, obtusifoliol, and lanosterol with minor quantities of C28 sterols.

Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

Existence of Candida albicans and microorganisms in denture stomatitis patients

1997 ◽  
Vol 24 (10) ◽  
pp. 788-790 ◽  
Author(s):  
Y. KULAK ◽  
A. ARIKAN ◽  
E. KAZAZOGLU
Keyword(s):  
Candida Albicans ◽  
Denture Stomatitis
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