Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

scholarly journals The Novel Arylamidine T-2307 MaintainsIn VitroandIn VivoActivity against Echinocandin-Resistant Candida albicans

2014 ◽  
Vol 59 (2) ◽  
pp. 1341-1343 ◽  
Author(s):  
Nathan P. Wiederhold ◽  
Laura K. Najvar ◽  
Annette W. Fothergill ◽  
Rosie Bocanegra ◽  
Marcos Olivo ◽  
...  
Keyword(s):  
Body Weight ◽  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Placebo Control ◽  
The Novel ◽  
Content Type ◽  
Fungal Burden ◽  
Potential Use

ABSTRACTWe evaluated thein vitroandin vivoactivities of the investigational arylamidine T-2307 against echinocandin-resistantCandida albicans. T-2307 demonstrated potentin vitroactivity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistantC. albicansinfections.

Off-label use of T2Candida® test in vitreous humor for diagnosing invasive candidiasis: a clinical report

2021 ◽  
Author(s):  
Emilio Cendejas-Bueno ◽  
Helena Peinado ◽  
Fernando Baquero-Artigao ◽  
Iker Falces-Romero ◽  
Cristina Calvo-Rey ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Vitreous Humor ◽  
Body Fluids ◽  
Clinical Report ◽  
Microbiological Diagnosis ◽  
Off Label Use ◽  
Off Label ◽  
Sterile Body Fluids ◽  
Label Use

Here, we present a case of off-label successful use of the T2 MR (T2Candida® test) for the diagnosis of invasive candidiasis ( Candida albicans endolphthalmitis). This case demonstrates that T2Candida could be performed in sterile body fluids to improve microbiological diagnosis of invasive candidiasis.

scholarly journals TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT

2015 ◽  
Vol 57 (3) ◽  
pp. 273-275 ◽  
Author(s):  
Xiao-Hua CHEN ◽  
Yun-Chao GAO ◽  
Yi ZHANG ◽  
Zheng-Hao TANG ◽  
Yong-Sheng YU ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Rare Case ◽  
Spinal Tuberculosis ◽  
Immunocompetent Patient ◽  
Antituberculous Therapy ◽  
Lower Back ◽  
Immunosuppressed Patients ◽  
History Of ◽  
Candida Infections

Deep Candida infections commonly occur in immunosuppressed patients. A rare case of a multiple deep organ infection with Candida albicans and spinal tuberculosis was reported in a healthy young man. The 19-year-old man complained of month-long fever and lower back pain. He also had a history of scalded mouth syndrome. Coinfection with Mycobacterium tuberculosis and Candida albicans was diagnosed using the culture of aspirates from different regions. Symptoms improved considerably after antifungal and antituberculous therapy. This case illustrates that infection with tuberculosis might impair the host's immune system and increase the risk of invasive candidiasis in an immunocompetent patient.

β-d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis

2015 ◽  
Vol 41 (8) ◽  
pp. 1424-1432 ◽  
Author(s):  
Estrella Martín-Mazuelos ◽  
Ana Loza ◽  
Carmen Castro ◽  
Desirée Macías ◽  
Ismail Zakariya ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Germ Tube ◽  
Icu Patients

scholarly journals Caspofungin Dose Escalation for Invasive Candidiasis Due to Resistant Candida albicans

2011 ◽  
Vol 55 (7) ◽  
pp. 3254-3260 ◽  
Author(s):  
Nathan P. Wiederhold ◽  
Laura K. Najvar ◽  
Rosie A. Bocanegra ◽  
William R. Kirkpatrick ◽  
Thomas F. Patterson
Keyword(s):  
Candida Albicans ◽  
Dose Escalation ◽  
Invasive Candidiasis ◽  
Hot Spot ◽  
Kidney Tissue ◽  
Resistant Isolate ◽  
Content Type ◽  
Tissue Burden ◽  
Higher Doses

ABSTRACTPreviousin vivostudies have reported caspofungin dose escalation to be effective againstCandida glabratawith reduced susceptibility. We hypothesized that higher doses of caspofungin would be effective against invasive candidiasis caused by the more virulent speciesCandida albicans, including isolates resistant to this echinocandin. Immunocompetent mice were inoculated with one of threeC. albicansisolates, including one susceptible and two resistant isolates with differentFKS1hot spot 1 point mutations. Mice received daily caspofungin treatment for 7 days and were then followed off therapy for 2 weeks to assess survival. Kidney tissue and blood were collected, and fungal burden and serum (1→3)-β-d-glucan were measured. Significant differences in virulence were observed among the threeC. albicansisolates, which translated into differences in responses to caspofungin. The most virulent of the resistant isolates studied (isolate 43001; Fks1p F641S) did not respond to caspofungin doses of up to 10 mg/kg of body weight, as there were no differences in survival (survival range, 0 to 12% with treatment), tissue burden, or (1→3)-β-d-glucan concentration compared to those for untreated controls. Higher doses of caspofungin did improve survival against the second resistant isolate (53264; Fks1p S645P) that demonstrated reduced virulence (5 and 10 mg/kg; 80% survival). In contrast, caspofungin doses as low as 1 mg/kg improved survival (85 to 95%) and reduced tissue burden and (1→3)-β-d-glucan concentration against the susceptible isolate (ATCC 90028). These data suggest that caspofungin dose escalation for invasive candidiasis may not be consistently effective against resistantC. albicansisolates, and this may be associated with the virulence of the strain.

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