scholarly journals Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2

Microbiology ◽  
2009 ◽  
Vol 155 (12) ◽  
pp. 4005-4013 ◽  
Author(s):  
Ruifu Zhang ◽  
John J. LiPuma ◽  
Carlos F. Gonzalez
Keyword(s):  
Type Iv Secretion ◽  
Burkholderia Cenocepacia ◽  
Target Cells ◽  
Secretion Systems ◽  
Type Iv ◽  
Plasmid Mobilization ◽  
Type Iv Secretion Systems ◽  
Derivative Plasmid ◽  
Chromosome Ii ◽  
Bacterial Type

Bacterial type IV secretion systems (T4SS) perform two fundamental functions related to pathogenesis: the delivery of effector molecules to eukaryotic target cells, and genetic exchange. Two T4SSs have been identified in Burkholderia cenocepacia K56-2, a representative of the ET12 lineage of the B. cepacia complex (Bcc). The plant tissue watersoaking (Ptw) T4SS encoded on a resident 92 kb plasmid is a chimera composed of VirB/D4 and F-specific subunits, and is responsible for the translocation of effector(s) that have been linked to the Ptw phenotype. The bc-VirB/D4 system located on chromosome II displays homology to the VirB/D4 T4SS of Agrobacterium tumefaciens. In contrast to the Ptw T4SS, the bc-VirB/D4 T4SS was found to be dispensable for Ptw effector(s) secretion, but was found to be involved in plasmid mobilization. The fertility inhibitor Osa did not affect the secretion of Ptw effector(s) via the Ptw system, but did disrupt the mobilization of a RSF1010 derivative plasmid.

scholarly journals Bacterial Type IV secretion systems: versatile virulence machines

2012 ◽  
Vol 7 (2) ◽  
pp. 241-257 ◽  
Author(s):  
Daniel E Voth ◽  
Laura J Broederdorf ◽  
Joseph G Graham
Keyword(s):  
Type Iv Secretion ◽  
Secretion Systems ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
Bacterial Type

scholarly journals The versatile bacterial type IV secretion systems

2003 ◽  
Vol 1 (2) ◽  
pp. 137-149 ◽  
Author(s):  
Eric Cascales ◽  
Peter J. Christie
Keyword(s):  
Type Iv Secretion ◽  
Secretion Systems ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
Bacterial Type

VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?

2008 ◽  
Vol 16 (9) ◽  
pp. 409-413 ◽  
Author(s):  
Steffen Backert ◽  
Remi Fronzes ◽  
Gabriel Waksman
Keyword(s):  
Type Iv Secretion ◽  
Secretion Systems ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
Bacterial Type

scholarly journals Biological Diversity of Prokaryotic Type IV Secretion Systems

2009 ◽  
Vol 73 (4) ◽  
pp. 775-808 ◽  
Author(s):  
Cristina E. Alvarez-Martinez ◽  
Peter J. Christie
Keyword(s):  
Target Cell ◽  
Biological Diversity ◽  
Cell Interaction ◽  
Type Iv Secretion ◽  
Target Cells ◽  
Secretion Systems ◽  
Extracellular Milieu ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
Cell Envelopes

SUMMARY Type IV secretion systems (T4SS) translocate DNA and protein substrates across prokaryotic cell envelopes generally by a mechanism requiring direct contact with a target cell. Three types of T4SS have been described: (i) conjugation systems, operationally defined as machines that translocate DNA substrates intercellularly by a contact-dependent process; (ii) effector translocator systems, functioning to deliver proteins or other macromolecules to eukaryotic target cells; and (iii) DNA release/uptake systems, which translocate DNA to or from the extracellular milieu. Studies of a few paradigmatic systems, notably the conjugation systems of plasmids F, R388, RP4, and pKM101 and the Agrobacterium tumefaciens VirB/VirD4 system, have supplied important insights into the structure, function, and mechanism of action of type IV secretion machines. Information on these systems is updated, with emphasis on recent exciting structural advances. An underappreciated feature of T4SS, most notably of the conjugation subfamily, is that they are widely distributed among many species of gram-negative and -positive bacteria, wall-less bacteria, and the Archaea. Conjugation-mediated lateral gene transfer has shaped the genomes of most if not all prokaryotes over evolutionary time and also contributed in the short term to the dissemination of antibiotic resistance and other virulence traits among medically important pathogens. How have these machines adapted to function across envelopes of distantly related microorganisms? A survey of T4SS functioning in phylogenetically diverse species highlights the biological complexity of these translocation systems and identifies common mechanistic themes as well as novel adaptations for specialized purposes relating to the modulation of the donor-target cell interaction.

Bacterial type IV secretion systems: a tool for DNA transfer into mammalian cells

2009 ◽  
Vol 25 ◽  
pp. S35
Author(s):  
E. Fernández-González ◽  
H.D. de Paz ◽  
C. Dehio ◽  
F.J. Sangari ◽  
M. Llosa
Keyword(s):  
Mammalian Cells ◽  
Type Iv Secretion ◽  
Dna Transfer ◽  
Secretion Systems ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
Bacterial Type

scholarly journals BIOGENESIS, ARCHITECTURE, AND FUNCTION OF BACTERIAL TYPE IV SECRETION SYSTEMS

2005 ◽  
Vol 59 (1) ◽  
pp. 451-485 ◽  
Author(s):  
Peter J. Christie ◽  
Krishnamohan Atmakuri ◽  
Vidhya Krishnamoorthy ◽  
Simon Jakubowski ◽  
Eric Cascales
Keyword(s):  
Type Iv Secretion ◽  
Secretion Systems ◽  
Type Iv ◽  
Type Iv Secretion Systems ◽  
And Function ◽  
Bacterial Type
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