scholarly journals NMDAR hypofunction increases top-down influence on sensory processing

2017 ◽  
Author(s):  
Adam Ranson ◽  
Eluned Broom ◽  
Anna Powell ◽  
Jeremy Hall
Keyword(s):  
Anterior Cingulate Cortex ◽  
Sensory Processing ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Top Down ◽  
Bottom Up

AbstractConverging evidence implicates NMDAR disruption in the pathogenesis of schizophrenia, a condition in which perceptual disturbances are prominent. To explore how NMDAR hypofunction causes perceptual symptoms we investigated activity in cortical sensory circuits in awake behaving mice during pharmacologically induced NMDAR hypofunction. We observed a reduction in sensory-driven activity in V1 while input from the anterior cingulate cortex simultaneously increased, suggesting NMDAR hypofunction may lead to altered perception by modifying the balance of top-down and bottom-up processing.

Oscillations as a window into neuronal mechanisms underlying dorsal Anterior Cingulate Cortex function

2020 ◽  
Author(s):  
Benjamin Voloh ◽  
Rachel Knoebl ◽  
Benjamin Hayden ◽  
Jan Zimmermann
Keyword(s):  
Anterior Cingulate Cortex ◽  
Explanatory Power ◽  
Field Potential ◽  
Empirical Support ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Top Down ◽  
Dorsal Anterior Cingulate Cortex ◽  
Bottom Up ◽  
Macro Scale

The function of dorsal Anterior Cingulate Cortex (dACC) remains poorly understood. While many methods, spanning bottom-up and top-down approaches, have been deployed, the view they offer is often conflicting. Integrating bottom up and top-down approaches requires an intermediary with sufficient explanatory power, theoretical development, and empirical support. Oscillations in the local field potential (LFP) provide such a link. LFP oscillations arise from empirically well-characterized neuronal circuit motifs. Synchronizing the firing of individual units has appealing properties to bind disparate brain regions and propagate information, including gating, routing, and coding. Moreover, the LFP, rather than single unit activity, more closely relates to macro-scale recordings, such as the electroencephologram and functional magnetic resonance imaging. Thus, LFP oscillations are a critical link that allow for the inference of neuronal micro-circuitry underlying macroscopic brain recordings.

scholarly journals Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Tao Chen ◽  
Wataru Taniguchi ◽  
Qi-Yu Chen ◽  
Hidetoshi Tozaki-Saitoh ◽  
Qian Song ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Top Down ◽  
Excitatory Transmission ◽  
Descending Facilitation

scholarly journals The time course of activity in dorsolateral prefrontal cortex and anterior cingulate cortex during top-down attentional control

NeuroImage ◽  
2010 ◽  
Vol 50 (3) ◽  
pp. 1292-1302 ◽  
Author(s):  
Rebecca Levin Silton ◽  
Wendy Heller ◽  
David N. Towers ◽  
Anna S. Engels ◽  
Jeffrey M. Spielberg ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Anterior Cingulate Cortex ◽  
Attentional Control ◽  
Dorsolateral Prefrontal Cortex ◽  
Time Course ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Top Down ◽  
Dorsolateral Prefrontal

scholarly journals Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control

Cell Reports ◽  
2018 ◽  
Vol 22 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Michael G. White ◽  
Matthew Panicker ◽  
Chaoqi Mu ◽  
Ashley M. Carter ◽  
Bradley M. Roberts ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Action Control ◽  
Anterior Cingulate ◽  
Top Down

Where and When the Anterior Cingulate Cortex Modulates Attentional Response: Combined fMRI and ERP Evidence

2006 ◽  
Vol 18 (5) ◽  
pp. 766-780 ◽  
Author(s):  
S. Crottaz-Herbette ◽  
V. Menon
Keyword(s):  
Anterior Cingulate Cortex ◽  
Attentional Control ◽  
Striate Cortex ◽  
Event Related Potentials ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Auditory Task ◽  
Top Down ◽  
Dipole Modeling ◽  
Related Potentials

Attentional control provides top-down influences that allow task-relevant stimuli and responses to be processed preferentially. The anterior cingulate cortex (ACC) plays an important role in attentional control, but the spatiotemporal dynamics underlying this process is poorly understood. We examined the activation and connectivity of the ACC using functional magnetic resonance imaging (fMRI) along with fMRI-constrained dipole modeling of event-related potentials (ERPs) obtained from subjects who performed auditory and visual oddball attention tasks. Although attention-related responses in the ACC were similar in the two modalities, effective connectivity analyses showed modality-specific effects with increased ACC influences on the Heschl and superior temporal gyri during auditory task and on the striate cortex during visual task. Dipole modeling of ERPs based on source locations determined from fMRI activations showed that the ACC was the major generator of N2b-P3a attention-related components in both modalities, and that primary sensory regions generated a small mismatch signal about 50 msec prior to feedback from the ACC and a large signal 60 msec after feedback from the ACC. Taken together, these results provide converging neuroimaging and electrophysiological evidence for top-down attentional modulation of sensory processing by the ACC. Our findings suggest a model of attentional control based on dynamic bottom-up and top-down interactions between the ACC and primary sensory regions.

EXPANSION OF THE ANTERIOR CINGULATE CORTEX IN CHILDREN WITH LEARNING DISABILITY OF UNKNOWN AETIOLOGY

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
M Mannerkoski ◽  
H Heiskala ◽  
K Van Leemput ◽  
L Åberg ◽  
R Raininko ◽  
...  
Keyword(s):  
Learning Disability ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Unknown Aetiology
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