scholarly journals The impact of headache disorders on COVID-19 survival: a world population-based analysis

2021 ◽  
Author(s):  
Robert E. Shapiro ◽  
Victor J. Gallardo ◽  
Edoardo Caronna ◽  
Patricia Pozo-Rosich
Keyword(s):  
Additive Model ◽  
Primary Headache ◽  
Population Level ◽  
Mortality Rates ◽  
Population Based ◽  
World Population ◽  
Headache Disorders ◽  
Primary Headache Disorders ◽  
Adaptive Processes ◽  
The Impact

Importance: COVID-19 has not impacted people or countries uniformly. This disparity has prompted investigations to identify clinical and genetic predictors of COVID-19 mortality. Headache, a COVID-19 symptom, has been associated with positive disease prognosis. It is logical to consider whether primary headache disorders, among the most prevalent and disabling diseases globally, may also be associated with reduced viral mortality and thereby may have arisen as adaptive host defences. Objective: To study the relationship between COVID-19 mortality and primary headache disorders. Main outcome measure: Using a generalized additive model regression (GAM), we analysed data across 171 nations to identify variables which impact COVID-19 mortality rates (demographics, national wealth and government effectiveness, pandemic management indexes, latitude of the country's capital, prevalence of headache disorders and other diseases). We performed similar analyses of seasonal influenza mortality. Separately, we meta-analysed studies of COVID-19 inpatient survival reporting headache, using PRISMA guidelines. Results: In the global population-level analysis, we observed that a higher prevalence of headache disorders was associated with a higher COVID-19 mortality rate, and represented the main variable contributing to differences in COVID-19 mortality rates between countries (37.8%; F value=10.68). By contrast, we observed a negative trend between the prevalence of headache disorders and influenza death rates. Controversially, when considering headache as a symptom of COVID-19, in the 48 meta-analysed studies we observed a significantly higher risk ratio of survival (RR:2.178 [1.882-2.520], p<0.0001) among COVID-19 inpatients with headache. Conclusions and Relevance: Headache as a primary disorder is more prevalent in nations with higher COVID-19 mortality, whereas headache as a COVID-19 symptom is associated with enhanced survival. Further studies should clarify whether primary headache disorders represent a risk factor for mortality for COVID-19 or, rather, whether this association reflects evolutionary adaptive processes to enhance survival that, in the case of COVID-19, are insufficiently protective.

Quality of life in primary headache disorders: A review

Cephalalgia ◽  
2015 ◽  
Vol 36 (1) ◽  
pp. 67-91 ◽  
Author(s):  
Norazah Abu Bakar ◽  
Surat Tanprawate ◽  
Giorgio Lambru ◽  
Mariam Torkamani ◽  
Marjan Jahanshahi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Primary Headache ◽  
Well Being ◽  
Headache Disorders ◽  
Primary Headache Disorders ◽  
Headache Type ◽  
Related Quality ◽  
Psychological Comorbidities ◽  
The Impact

Background Health-related quality of life (HRQoL) is emerging as an important element of clinical research in primary headache disorders, allowing a measure of the impact of headache on patients’ well-being and daily life. A better understanding of this may contribute to improved resource allocations and treatment approaches. Objective The objective of this study is to review available data on HRQoL in primary headache disorders and identify any influencing factors. Methods Database searches including MEDLINE, PsycINFO and EMBASE were performed. Studies that investigated HRQoL in patients with primary headache disorders were included and reviewed. Trials that evaluated the efficacy of medications or interventions were excluded. Results A total of 80 articles were included in the review. Both physical and emotional/mental aspects of HRQoL were impaired across headache subtypes, although the extent varied depending on headache type. A number of factors influencing HRQoL were also identified. Conclusion This narrative review suggests that headache, particularly in its chronic form, has a great impact on HRQoL. Clinical practice should not solely focus on pain alleviation but rather adopt routine assessment of HRQoL. Furthermore, identification and management of associated psychological comorbidities, which can significantly influence HRQoL in headache sufferers, are essential for optimal clinical management.

scholarly journals Comorbidities of primary headache disorders: a literature review with meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Valeria Caponnetto ◽  
Manuela Deodato ◽  
Micaela Robotti ◽  
Maria Koutsokera ◽  
Valeria Pozzilli ◽  
...  
Keyword(s):  
Back Pain ◽  
Depressive Disorders ◽  
Population Studies ◽  
Meta Analysis ◽  
Primary Headache ◽  
Global Burden ◽  
Primary Headaches ◽  
Headache Disorders ◽  
Primary Headache Disorders ◽  
The Impact

Abstract Background Primary headache disorders are common and burdensome conditions. They are associated to several comorbidities, such as cardiovascular or psychiatric ones, which, in turn, contribute to the global burden of headache. The aim of this study is to provide a comprehensive description of the pooled prevalence of comorbidities of primary headache disorders using a meta-analytical approach based on studies published between 2000 and 2020. Methods Scopus was searched for primary research (clinical and population studies) in which medical comorbidities were described in adults with primary headache disorders. Comorbidities were extracted using a taxonomy derived from the Global Burden of Disease (GBD) study. We compared prevalence of comorbidities among headache sufferers against general population using GBD-2019 estimates, and compared comorbidities’ proportions in clinical vs. population studies, and by age and gender. Results A total of 139 studies reporting information on 4.19 million subjects with primary headaches were included: in total 2.75 million comorbidities were reported (median per subject 0.64, interquartile range 0.32–1.07). The most frequently addressed comorbidities were: depressive disorders, addressed in 51 studies (pooled proportion 23 %, 95 % CI 20–26 %); hypertension, addressed in 48 studies (pooled proportion 24 %, 95 % CI 22–26 %); anxiety disorders addressed in 40 studies (pooled proportion 25 %, 95 % CI 22–28 %). For conditions such as anxiety, depression and back pain, prevalence among headache sufferers was higher than in GBD-2109 estimates. Associations with average age and female prevalence within studies showed that hypertension was more frequent in studies with higher age and less females, whereas fibromyalgia, restless leg syndrome, and depressive disorders were more frequent in studies with younger age and more female. Conclusions Some of the most relevant comorbidities of primary headache disorders – back pain, anxiety and depression, diabetes, ischemic heart disease and stroke – are among the most burdensome conditions, together with headache themselves, according to the GBD study. A joint treatment of headaches and of these comorbidities may positively impact on headache sufferers’ health status and contribute to reduce the impact of a group of highly burdensome diseases.

scholarly journals The epidemiology of primary headache disorders in Zambia: a population-based door-to-door survey

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Edward Mbewe ◽  
Pachuau Zairemthiama ◽  
Hsueh-Han Yeh ◽  
Ravi Paul ◽  
Gretchen L Birbeck ◽  
...  
Keyword(s):  
Primary Headache ◽  
Population Based ◽  
Headache Disorders ◽  
Primary Headache Disorders

scholarly journals The Opioid Epidemic and Primary Headache Disorders: A Nationwide Population-Based Study

Cureus ◽  
2020 ◽  
Author(s):  
Urvish K Patel ◽  
Preeti Malik ◽  
Dhaivat Shah ◽  
Ashish Sharma ◽  
Jatminderpal Bhela ◽  
...  
Keyword(s):  
Primary Headache ◽  
Population Based ◽  
Opioid Epidemic ◽  
Headache Disorders ◽  
Population Based Study ◽  
Primary Headache Disorders

scholarly journals Telemedicine in the Management of Primary Headaches: A Critical Review

2019 ◽  
pp. 198-202
Author(s):  
Renan Barros Domingues ◽  
Cassio Batista Lacerda ◽  
Paulo Diego Santos Silva
Keyword(s):  
Health Care Services ◽  
Primary Headache ◽  
Communication Technologies ◽  
Primary Headaches ◽  
Headache Disorders ◽  
Primary Headache Disorders ◽  
Care Services ◽  
Services Delivery ◽  
The Impact

Telemedicine is a modality of health care services delivery with the use of communication technologies. Its use has grown in several medicine areas. Several studies evaluated the feasibility, acceptance, efficacy, cost-effectiveness, and safety of telemedicine in the diagnosis and management of primary headache disorders. Videoconsultations were shown to be effective, convenient, and safe for primary headache disorders and migraine follow up. Some mobile health devices were show to improve adherence favoring better outcomes. Handling health data is a major concern so that international compliance standards must be adopted in all telemedicine procedures. The impact in the health system and increased access to appropriate primary headache treatments with the use of these technologies has yet to be elucidated.

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