scholarly journals Phylodynamic signatures in the emergence of community-associated MRSA

2021 ◽  
Author(s):  
Eike Steinig ◽  
Izzard Aglua ◽  
Sebastián Duchêne ◽  
Michael T. Meehan ◽  
Mition Yoannes ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
New Guinea ◽  
Whole Genome Sequencing Data ◽  
Northern Australia ◽  
Sequencing Data ◽  
Late 20Th Century ◽  
Antibiotic Resistant ◽  
Far North ◽  
Regional Population ◽  
Resistant Genotypes

Community-associated, methicillin-resistant Staphylococcus aureus (MRSA) lineages have emerged in many geographically distinct regions around the world during the past 30 years. Here, we apply consistent phylodynamic methods across multiple community-associated MRSA lineages to describe and contrast their patterns of emergence and dissemination. We generated whole genome sequencing data for the Australian sequence type (ST) 93-MRSA-IV from remote communities in Far North Queensland and Papua New Guinea, and the Bengal Bay ST772-MRSA-V clone from metropolitan communities in Pakistan. Increases in the effective reproduction number (Re) and sustained transmission (Re > 1) coincided with spread of progenitor methicillin-susceptible S. aureus (MSSA) in remote northern Australia, dissemination of the ST93-MRSA-IV geno-type into population centers on the Australian East Coast, and sub-sequent importation into the highlands of Papua New Guinea and Far North Queensland. Analysis of a ST772-MRSA-V cluster in Pakistan suggests that sustained transmission in the community following importation of resistant genotypes may be more common than previously thought. Applying the same phylodynamic methods to existing lineage datasets, we identified common signatures of epidemic growth in the emergence and epidemiological trajectory of community-associated S. aureus lineages from America, Asia, Australasia and Europe. Surges in Re were observed at the divergence of antibiotic resistant strains, coinciding with their establishment in regional population centers. Epidemic growth was also observed amongst drug-resistant MSSA clades in Africa and northern Australia. Our data suggest that the emergence of community-associated MRSA and MSSA lineages in the late 20th century was driven by a combination of antibiotic resistant genotypes and host epidemiology, leading to abrupt changes in lineage-wide transmission dynamics and sustained transmission in regional population centers.

Revision of the genus Mitelloides Evans, with two new species from northern Australia (Homoptera: Cicadellidae)

1990 ◽  
Vol 21 (3) ◽  
pp. 281-288
Author(s):  
M.M. Stevens
Keyword(s):  
New Species ◽  
Papua New Guinea ◽  
Type Species ◽  
New Guinea ◽  
Northern Australia ◽  
North East ◽  
Two New Species ◽  
Torres Strait

AbstractThe genus Mitelloides Evans is revised. Three species are recognised and described; M. moaensis Evans (the type species) and two new species, M. thorntonensís and M. mouldsi. A key to the males of the genus is provided, and the known distributions of all species are mapped. The genus is known only from north-east Queensland, the Torres Strait Islands, and Papua New Guinea.

scholarly journals A revision of the ant genus Probolomyrmex (Hymenoptera: Formicidae: Proceratiinae) in Australia and Melanesia

Zootaxa ◽  
2012 ◽  
Vol 3444 (1) ◽  
pp. 40 ◽  
Author(s):  
S. O. SHATTUCK ◽  
N. R. GUNAWARDENE ◽  
B. HETERICK
Keyword(s):  
Papua New Guinea ◽  
New Guinea ◽  
Species Group ◽  
Northern Australia ◽  
First Time

Five species of the rarely encountered ant genus Probolomyrmex are known from Australia and Papua New Guinea, four of which are described here for the first time. Two species belong to the greavesi species-group (P. greavesi, P. latalongus sp. n.) while three belong to the longinodus species-group (P. aliundus sp. n., P. newguinensis sp. n., P. simplex sp. n.). The genus is now known to occur broadly across northern Australia and P. newguinensis and P. simplex are the first species of the genus described from Papua New Guinea. A key to Australian and Melanesian species is provided.

scholarly journals Network analysis reveals differential metabolic functionality in antibiotic-resistantPseudomonas aeruginosa

2018 ◽  
Author(s):  
Laura J. Dunphy ◽  
Phillip Yen ◽  
Jason A. Papin
Keyword(s):  
Antibiotic Resistance ◽  
Carbon Sources ◽  
Growth Dynamics ◽  
Metabolic Phenotype ◽  
Metabolic Adaptation ◽  
Whole Genome Sequencing Data ◽  
Sequencing Data ◽  
Drug Induced ◽  
Antibiotic Resistant ◽  
A Genome

AbstractMetabolic adaptations accompanying the development of antibiotic resistance in bacteria remain poorly understood. To interrogate this relationship, we profiled the growth of lab-evolved antibiotic-resistant lineages of the opportunistic pathogenPseudomonas aeruginosaacross 190 unique carbon sources. We semi-automatically calculated growth dynamics (maximum growth density, growth rate, and time to mid-exponential phase) of over 2,800 growth curves. These data revealed that the evolution of antibiotic resistance resulted in systems-level changes to growth dynamics and metabolic phenotype. Drug-resistant lineages predominantly displayed decreased growth relative to the ancestral lineage; however, resistant lineages occasionally displayed enhanced growth on certain carbon sources, indicating that adaption to drug can provide a growth advantage in certain environments. A genome-scale metabolic network reconstruction (GENRE) ofP. aeruginosastrain UCBPP-PA14 was paired with whole-genome sequencing data of one of the drug-evolved lineages to predict genes contributing to observed changes in metabolism. Finally, we experimentally validatedin silicopredictions to identify genes mutated in resistantP. aeruginosaaffecting loss of catabolic function. Our results build upon previous mechanistic knowledge of drug-induced metabolic adaptation and provide a framework for the identification of metabolic limitations in antibiotic-resistant pathogens. Robust drug-driven changes in bacterial metabolism have the potential to be exploited to select against antibiotic-resistant populations in chronic infections.

scholarly journals TOWARDS A FLORA OF NEW GUINEA: OLEACEAE. PART 1. JASMINUM, LIGUSTRUM, MYXOPYRUM AND OLEA.

REINWARDTIA ◽  
2020 ◽  
Vol 19 (1) ◽  
pp. 1-25
Author(s):  
Ruth Kiew
Keyword(s):  
Papua New Guinea ◽  
Endemic Species ◽  
Pacific Islands ◽  
New Caledonia ◽  
New Guinea ◽  
The Philippines ◽  
Peninsular Malaysia ◽  
Far North ◽  
Coastal Species ◽  
The Pacific

KIEW, R. 2020. Towards a Flora of New Guinea: Oleaceae. Part 1. Jasminum, Ligustrum, Myxopyrum and Olea. Reinwardtia 19(1): 1‒25. ‒‒ Oleaceae in New Guinea is represented by five genera and about 32 species, namely Chionanthus (about 16 species), Jasminum (10 species), Ligustrum (3 species), Myxopyrum (2 species) and Olea (1 species). A key to genera as well as descriptions of and keys to species of Jasminum, Ligustrum, Myxopyrum and Olea are provided. Of the three Ligustrum species, L. glomeratum is widespread throughout Malesia, L. novoguineense is endemic and L. parvifolium Kiew is a new endemic species. Six species of Jasminum are endemic (J. domatiigerum, J. gilgianum, J. magnificum, J. papuasicum, J. pipolyi and J. rupestre). Jasminum turneri just reaches the northern tip of Australia; of the two species from the Pacific Islands J. simplicifolium subsp. australiense just reaches SE Papua New Guinea and J. didymum, a coastal species, reaches into Malesia as far north as E Java; J. elongatum is widespread from Asia to Australia. Neither Myxopyrum species is endemic: M. nervosum subsp. nervosum extends from Peninsular Malaysia to Indonesian New Guinea, and M. ovatum from the Philippines to the Admiralty Islands. The sole species of Olea, O. paniculata, stretches from Java to Australia and New Caledonia. 

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