scholarly journals Naturalistic Audiovisual Stimulation Reveals the Topographic Organization of Human Auditory Cortex

2021 ◽  
Author(s):  
Nicholas Hedger ◽  
Tomas Knapen
Keyword(s):  
Auditory Cortex ◽  
Receptive Fields ◽  
Low Frequency ◽  
Stimulus Category ◽  
Relevant Stimulus ◽  
Audiovisual Stimulation ◽  
Topographic Organization ◽  
Cortical Hierarchy ◽  
Human Auditory Cortex ◽  
Visual Cortical

Despite the importance of audition in spatial, semantic, and social function, there is no consensus regarding the detailed organisation of human auditory cortex. Using a novel computational model to analyse a high-powered naturalistic audiovisual movie-watching dataset, we simultaneously estimate spectral tuning properties and category selectivity to reveal the modes of organisation and computational motifs that characterise human auditory cortex. We find that regions more remote from the auditory core exhibit more compressive, non-linear response properties and finely-tuned, speech-selective receptive fields in low frequency portions of the tonotopic map. These patterns of organisation mirror aspects of the visual cortical hierarchy, wherein tuning properties progress from a stimulus category-agnostic front end towards more advanced regions increasingly optimised for behaviorally relevant stimulus categories.

scholarly journals Sparse Spectro-Temporal Receptive Fields Based on Multi-Unit and High-Gamma Responses in Human Auditory Cortex

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137915 ◽  
Author(s):  
Rick L. Jenison ◽  
Richard A. Reale ◽  
Amanda L. Armstrong ◽  
Hiroyuki Oya ◽  
Hiroto Kawasaki ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Receptive Fields ◽  
High Gamma ◽  
Human Auditory Cortex

scholarly journals Mapping the human auditory cortex using spectrotemporal receptive fields generated with magnetoencephalography

2020 ◽  
Author(s):  
Jean-Pierre R. Falet ◽  
Jonathan Côté ◽  
Veronica Tarka ◽  
Zaida-Escila Martinez-Moreno ◽  
Patrice Voss ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Auditory Processing ◽  
Spatial Organization ◽  
Temporal Dynamics ◽  
Functional Organization ◽  
Receptive Fields ◽  
Spectrotemporal Receptive Fields ◽  
Modulation Rate ◽  
Human Auditory Cortex ◽  
Time Required

AbstractWe present a novel method to map the functional organization of the human auditory cortex noninvasively using magnetoencephalography (MEG). More specifically, this method estimates via reverse correlation the spectrotemporal receptive fields (STRF) in response to a dense pure tone stimulus, from which important spectrotemporal characteristics of neuronal processing can be extracted and mapped back onto the cortex surface. We show that several neuronal populations can be found examining the spectrotemporal characteristics of their STRFs, and demonstrate how these can be used to generate tonotopic gradient maps. In doing so, we show that the spatial resolution of MEG is sufficient to reliably extract important information about the spatial organization of the auditory cortex, while enabling the analysis of complex temporal dynamics of auditory processing such as best temporal modulation rate and response latency given its excellent temporal resolution. Furthermore, because spectrotemporally dense auditory stimuli can be used with MEG, the time required to acquire the necessary data to generate tonotopic maps is significantly less for MEG than for other neuroimaging tools that acquire BOLD-like signals.

scholarly journals Hierarchy of speech-driven spectrotemporal receptive fields in human auditory cortex

NeuroImage ◽  
2019 ◽  
Vol 186 ◽  
pp. 647-666 ◽  
Author(s):  
Jonathan H. Venezia ◽  
Steven M. Thurman ◽  
Virginia M. Richards ◽  
Gregory Hickok
Keyword(s):  
Auditory Cortex ◽  
Receptive Fields ◽  
Spectrotemporal Receptive Fields ◽  
Human Auditory Cortex

scholarly journals Mapping the human auditory cortex using spectrotemporal receptive fields generated with magnetoencephalography

NeuroImage ◽  
2021 ◽  
pp. 118222
Author(s):  
Jean-Pierre R. Falet ◽  
Jonathan Côté ◽  
Veronica Tarka ◽  
Zaida-Escila Martinez-Moreno ◽  
Patrice Voss ◽  
...  
Keyword(s):  
Auditory Cortex ◽  
Receptive Fields ◽  
Spectrotemporal Receptive Fields ◽  
Human Auditory Cortex

scholarly journals Attention selectively gates afferent signal transmission to area V4

2015 ◽  
Author(s):  
Iris Grothe ◽  
David Rotermund ◽  
Simon D. Neitzel ◽  
Sunita Mandon ◽  
Udo A. Ernst ◽  
...  
Keyword(s):  
Selective Attention ◽  
Cortical Neurons ◽  
Signal Transmission ◽  
Receptive Fields ◽  
Low Frequency ◽  
Area V4 ◽  
Gating Mechanism ◽  
V4 Neurons ◽  
Visual Cortical ◽  
Signal Routing

Selective attention causes visual cortical neurons to act as if only one of multiple stimuli are within their receptive fields. This suggests that attention employs a, yet unknown, neuronal gating mechanism for transmitting only the information that is relevant for the current behavioral context. We introduce an experimental paradigm to causally investigate this putative gating and the mechanism underlying selective attention by determining the signal availability of two time-varying stimuli in local field potentials of V4 neurons. We find transmission of the low frequency (<20Hz) components only from the attended visual input signal and that the higher frequencies from both stimuli are attenuated. A minimal model implementing routing by synchrony replicates the attentional gating effect and explains the spectral transfer characteristics of the signals. It supports the proposal that selective gamma-band synchrony subserves signal routing in cortex and further substantiates our experimental finding that attention selectively gates signals already at the level of afferent synaptic input.

Ultrastructure of developing visual cortical synapses in the cat superior colliculus

1991 ◽  
Vol 49 ◽  
pp. 156-157
Author(s):  
Caroline A. Miller ◽  
Laura L. Bruce
Keyword(s):  
Superior Colliculus ◽  
Phosphate Buffer ◽  
Receptive Fields ◽  
Visual Cortical Area ◽  
Cortical Synapses ◽  
Visual Cortical ◽  
And Function ◽  
Phosphate Buffered Saline ◽  
The Brain ◽  
Cat Superior Colliculus

The first visual cortical axons arrive in the cat superior colliculus by the time of birth. Adultlike receptive fields develop slowly over several weeks following birth. The developing cortical axons go through a sequence of changes before acquiring their adultlike morphology and function. To determine how these axons interact with neurons in the colliculus, cortico-collicular axons were labeled with biocytin (an anterograde neuronal tracer) and studied with electron microscopy.Deeply anesthetized animals received 200-500 nl injections of biocytin (Sigma; 5% in phosphate buffer) in the lateral suprasylvian visual cortical area. After a 24 hr survival time, the animals were deeply anesthetized and perfused with 0.9% phosphate buffered saline followed by fixation with a solution of 1.25% glutaraldehyde and 1.0% paraformaldehyde in 0.1M phosphate buffer. The brain was sectioned transversely on a vibratome at 50 μm. The tissue was processed immediately to visualize the biocytin.

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