scholarly journals Analysis of the upper respiratory tract microbiota in mild and severe COVID-19 patients

2021 ◽  
Author(s):  
V. Babenko ◽  
R. Bakhtyev ◽  
V. Baklaushev ◽  
L. Balykova ◽  
P. Bashkirov ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Lung Damage ◽  
Infectious Agents ◽  
Upper Respiratory Tract ◽  
Differential Abundance ◽  
Community Types ◽  
Upper Respiratory ◽  
Differential Abundance Analysis ◽  
Respiratory Microbiota ◽  
Severe Lung

AbstractThe microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, like the intestinal microbiota, it is involved in modulating the immune response to infectious agents in the host organism. A causal relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be hypothesized. We analyze biomaterial from nasopharyngeal smears from 336 patients with a confirmed diagnosis of COVID-19, selected during the first and second waves of the epidemic in Russia. Sequences from a similar study conducted in Spain were also included in the analysis. We investigated associations between disease severity and microbiota at the level of microbial community (community types) and individual microbes (differentially represented species). To search for associations, we performed multivariate analysis, taking into account comorbidities, type of community and lineage of the virus. We found that two out of six community types are associated with a more severe course of the disease, and one of the community types is characterized by high stability (very similar microbiota profiles in different patients) and low level of lung damage. Differential abundance analysis with respect to comorbidities and community type suggested association of Rothia and Streptococcus genera representatives with more severe lung damage, and Leptotrichia, unclassified Lachnospiraceae and Prevotella with milder forms of the disease.

scholarly journals Respiratory microbiota disorders in children with neurological disabilities at repeated respiratory diseases

2021 ◽  
pp. 53-56
Author(s):  
Olena Koreniuk
Keyword(s):  
Respiratory Tract ◽  
Respiratory Diseases ◽  
Clinical Symptoms ◽  
Invasive Technique ◽  
Upper Respiratory Tract ◽  
Bronchopulmonary Diseases ◽  
Upper Respiratory ◽  
Neurological Pathology ◽  
Respiratory Microbiota ◽  
Neurological Disabilities

  The relevance of the problem of recurrent respiratory diseases in children with severe neurological pathology is due to the high frequency, severity of clinical symptoms and the protracted nature of their exacerbations, as well as the tendency to chronicity of the pathological process. The aim of the research was to study the respiratory microbiota to optimize antibacterial therapy of recurrent respiratory diseases. Materials and methods: the 16 children with severe neurological pathology at repeated respiratory diseases were examined. We used a microbiological examination of the upper respiratory tract using a deep smear from the oropharynx to identify a possible causative agent of the disease. Research results: the pronounced imbalance of the respiratory microbiota, corresponding to II and III degrees of dysbiotic disorders, was revealed in the examined children. The feature of the microflora of the upper respiratory tract was the dominance of Pseudomonas aeroginosa, intestinal opportunistic microflora (Klebsiella pneumoniae, Proteus vulgaris) and their frequent combination with Streptococcus pyogenus, Staphylococcus aureus and yeast-like mushrooms of the Сandida genus. The maximum degree of respiratory microbiota disorders was noted in the group of children with congenital malformations of the brain and correlated with the severity of bronchopulmonary diseases. The analysis of the pathogenic microflora sensitivity to antibiotics showed high resistance of the identified microorganisms to most medicines. Conclusions: respiratory pathology in children with neurological disabilities is characterized by a recurrent and chronic bronchitis with a tendency of a protracted course which determines the duration of antibiotic therapy. The use of a non-invasive technique for the respiratory microbiota studying makes it possible to identify suspected pathogens of bronchopulmonary diseases and optimize their treatment

scholarly journals Antiviral and immunomodulatory effects of Engystol

2019 ◽  
pp. 116-120
Author(s):  
R. A. Hanferian ◽  
N. A. Daihes ◽  
O. V. Karneeva ◽  
T. I. Garashchenko ◽  
I. A. Kim
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Symptomatic Treatment ◽  
Infectious Agents ◽  
Upper Respiratory Tract ◽  
Immunomodulatory Effects ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Tract Infections ◽  
Complex Drug

Respiratory tract infections are among the most common diseases. Most upper respiratory tract infections (URTI) are viral in nature. More than 200 types of viruses, including influenza, parainfluenza, respiratory syncytial virus (RSV), rhinovirus (HRV) and adenovirus (AV), may be the cause of URTI; in some cases, other infectious agents are the cause. The most common pathogens are rhinoviruses, which account for more than 50 per cent of the URTI. The article presents data on the efficacy of Engystol®, a complex drug containing low doses of active ingredients and used for prevention and symptomatic treatment of a number of viral diseases.

scholarly journals ON THE ROLE OF COLLOID SILVER IN THE TREATMENT OF UPPER RESPIRATORY TRACT AND EAR DISORDERS

2017 ◽  
pp. 56-59
Author(s):  
N. E. BOIKOVA
Keyword(s):  
Respiratory Tract ◽  
Chronic Diseases ◽  
Broad Spectrum ◽  
High Resistance ◽  
Infectious Agents ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Colloid Silver

The high resistance of infectious agents to antibiotics that doctors currently face in therapy of acute and chronic diseases, especially in ENT-practice makes it possible for experts to search for alternative paths and to select drugs with a broad spectrum of action. These include colloid silver based drugs with proven microbicidal, virucidal and local protective and anti-inflammatory properties

Allergy of the Upper Respiratory Tract

1970 ◽  
Vol 3 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Jack D. Clemis ◽  
Eugene L. Derlacki
Keyword(s):  
Respiratory Tract ◽  
Upper Respiratory Tract ◽  
Upper Respiratory
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