Spontaneous DNA synapsis by forming noncanonical intermolecular structures
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We report the spontaneous formation of DNA-DNA junctions in solution in the absence of proteins visualised using atomic force microscopy. The synapsis position fits with potential G-quadruplex (G4) sites. In contrast to the Holliday structure, these conjugates have affinity for G4 antibodies. Molecular modelling was used to elucidate the possible G4/IM-synaptic complex structures. Our results indicate a new role of the intermolecular noncanonical structures in chromatin architecture and genomic rearrangement.
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2004 ◽
Vol 42
(4)
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pp. 687-701
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2011 ◽
Vol 3
(6)
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pp. 702-716
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2009 ◽
Vol 22
(5)
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pp. 347-355
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