scholarly journals Modelling cost-effectiveness of tenofovir for prevention of mother to child transmission of hepatitis B virus infection in South Africa

2018 ◽  
Author(s):  
Jolynne Mokaya ◽  
Edward Burn ◽  
Cynthia Raissa Tamandjou ◽  
Dominique Goedhals ◽  
Eleanor Barnes ◽  
...  

ABSTRACTIn light of sustainable development goals for 2030, an important priority for Africa is to have affordable, accessible and sustainable hepatitis B virus (HBV) prevention of mother to child transmission (PMTCT) programmes, delivering screening and treatment for antenatal women and implementing timely administration of HBV vaccine for their babies. We developed a decision-analytic model simulating 10,000 singleton pregnancies to assess the cost-effectiveness of three possible strategies for deployment of tenofovir in pregnancy, in combination with routine infant vaccination: S1: no screening nor antiviral therapy; S2: screening and antiviral prophylaxis for all women who test HBsAg-positive; S3: screening for HBsAg, followed by HBeAg testing and antiviral prophylaxis for women who are HBsAg-positive and HBeAg-positive. Our outcome was cost per infant HBV infection avoided and the analysis followed a healthcare perspective. S1 predicts 45 infants would be HBV-infected at six months of age, compared to 21 and 28 infants in S2 and S3, respectively. Relative to S1, S2 had an incremental cost of $3,940 per infection avoided. S3 led to more infections and higher costs. Given the long-term health burden for individuals and economic burden for society associated with chronic HBV infection, screening pregnant women and providing tenofovir for all who test HBsAg+ may be a cost-effective strategy for South Africa.

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jolynne Mokaya ◽  
Edward A. O. Burn ◽  
Cynthia Raissa Tamandjou ◽  
Dominique Goedhals ◽  
Eleanor J. Barnes ◽  
...  

2015 ◽  
Vol 54 (7) ◽  
pp. 711-716 ◽  
Author(s):  
Cui-Ping Liu ◽  
Yi-Lan Zeng ◽  
Min Zhou ◽  
Lan-Lan Chen ◽  
Rong Hu ◽  
...  

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