scholarly journals Deep Brain Stimulation of the Ventromedial Prefrontal Cortex Disrupts Consolidation of Fear Memories

2019 ◽  
Author(s):  
Shawn Zheng Kai Tan ◽  
Chi Him Poon ◽  
Ying-Shing Chan ◽  
Lee Wei Lim
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Anxiety Disorders ◽  
Brain Stimulation ◽  
Ventromedial Prefrontal Cortex ◽  
Short Term ◽  
Conditioning Paradigm ◽  
Plus Maze ◽  
Deep Brain

ABSTRACTAnxiety disorders pose one of the biggest threats to mental health worldwide, yet current therapeutics have been mostly ineffective due to issues with relapse, efficacy, and toxicit. Deep brain stimulation (DBS) is a promising therapy for treatment-resistant psychiatric disorders including anxiety, but very little is known about the effects of DBS on fear memories. In this study, we used a modified plus-maze discriminative and showed that DBS of the ventromedial prefrontal cortex (vmPFC) was able to disrupt consolidation, but not acquisition or retrieval of fear memories. We validated these results using a standard tone-footshock fear conditioning paradigm. We further demonstrated short-term changes in dopaminergic receptor and c-Fos expression in the ventral hippocampus (vHPC) and established a partial casual role of dopamine 2 receptors in this effect. Lastly, we showed changes in neurotransmitter levels in the vHPC. This study highlights the potential therapeutic effect of vmPFC DBS to treat anxiety disorders.

Investigating the role of CB1 endocannabinoid transmission in the anti-fear and anxiolytic-like effects of ventromedial prefrontal cortex deep brain stimulation

2021 ◽  
Vol 135 ◽  
pp. 264-269
Author(s):  
Darryl C. Gidyk ◽  
Mustansir Diwan ◽  
Flavia Venetucci Gouveia ◽  
Peter Giacobbe ◽  
Nir Lipsman ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventromedial Prefrontal Cortex ◽  
Deep Brain

scholarly journals Effect of Deep Brain Stimulation of the ventromedial prefrontal cortex on the noradrenergic system in rats

2018 ◽  
Vol 11 (1) ◽  
pp. 222-230 ◽  
Author(s):  
Sonia Torres-Sanchez ◽  
Laura Perez-Caballero ◽  
Juan A. Mico ◽  
Pau Celada ◽  
Esther Berrocoso
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventromedial Prefrontal Cortex ◽  
Noradrenergic System ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the ventromedial prefrontal cortex causes reorganization of neuronal processes and vasculature

NeuroImage ◽  
2016 ◽  
Vol 125 ◽  
pp. 422-427 ◽  
Author(s):  
M. Mallar Chakravarty ◽  
Clement Hamani ◽  
Alonso Martinez-Canabal ◽  
Jacob Ellegood ◽  
Christine Laliberté ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventromedial Prefrontal Cortex ◽  
Neuronal Processes ◽  
Deep Brain ◽  
Stimulation Of

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

2015 ◽  
Vol 8 (4) ◽  
pp. 714-723 ◽  
Author(s):  
Henriette Edemann-Callesen ◽  
Mareike Voget ◽  
Laura Empl ◽  
Martin Vogel ◽  
Franziska Wieske ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Medial Forebrain Bundle ◽  
Reward System ◽  
Ventromedial Prefrontal Cortex ◽  
Deep Brain

scholarly journals Deep Brain Stimulation Reveals Emotional Impact Processing in Ventromedial Prefrontal Cortex

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8120 ◽  
Author(s):  
Albert Gjedde ◽  
Jacob Geday
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Ventromedial Prefrontal Cortex ◽  
Emotional Impact ◽  
Deep Brain

scholarly journals Subcortical short‐term plasticity elicited by deep brain stimulation

2021 ◽  
Author(s):  
Mohammad Z. Awad ◽  
Ryan J. Vaden ◽  
Zachary T. Irwin ◽  
Christopher L. Gonzalez ◽  
Sarah Black ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Short Term Plasticity ◽  
Deep Brain

Deep brain stimulation in headache

Cephalalgia ◽  
2016 ◽  
Vol 36 (12) ◽  
pp. 1143-1148 ◽  
Author(s):  
Massimo Leone ◽  
Alberto Proietti Cecchini
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Chronic Cluster Headache ◽  
Hypothalamic Stimulation ◽  
Hypothalamic Area ◽  
Unilateral Headache ◽  
Randomised Controlled ◽  
Invasive Neurostimulation ◽  
Deep Brain

Background: Deep brain stimulation of the posterior hypothalamic area was first introduced in 2000 to treat drug-refractory chronic cluster headache (CH). Findings: So far, hypothalamic stimulation has been employed in 79 patients suffering from various forms of intractable short-lasting unilateral headache forms, mainly trigeminal autonomic cephalalgias. The majority were (88.6%) chronic CH, including one patient who suffered from symptomatic chronic CH-like attacks; the remaining were short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), one had paroxysmal hemicranias and one symptomatic trigeminal neuralgia. Overall, after a mean follow up of 2.2 years, 69.6% (55) hypothalamic-stimulated patients showed a ≥50% improvement. Conclusions: These observations need confirmation in randomised, controlled trials. A key role of the posterior hypothalamic area in the pathophysiology of unilateral short-lasting headaches, possibly by regulating the duration rather than triggering the attacks, can be hypothesised. Because of its invasiveness, hypothalamic stimulation can be proposed only after other, less-invasive, neurostimulation procedures have been tried.

The Role of the Neuropsychologist in Deep Brain Stimulation

2019 ◽  
pp. 185-228
Author(s):  
Alexander I. Tröster
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Deep Brain
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