Short‐term changes in cortical physiological arousal measured by electroencephalography during thalamic centromedian deep brain stimulation

Epilepsia ◽  
2021 ◽  
Author(s):  
Reese A. Martin ◽  
Arthur Cukiert ◽  
Hal Blumenfeld
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Physiological Arousal ◽  
Short Term ◽  
Deep Brain

scholarly journals Subcortical short‐term plasticity elicited by deep brain stimulation

2021 ◽  
Author(s):  
Mohammad Z. Awad ◽  
Ryan J. Vaden ◽  
Zachary T. Irwin ◽  
Christopher L. Gonzalez ◽  
Sarah Black ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Short Term Plasticity ◽  
Deep Brain

scholarly journals Depression and Anxiety Following Deep Brain Stimulation in Parkinson’s Disease: Systematic Review and Meta-Analysis

2014 ◽  
Vol 27 (3) ◽  
pp. 372 ◽  
Author(s):  
Maria Inês Couto ◽  
Ana Monteiro ◽  
Ana Oliveira ◽  
Nuno Lunet ◽  
João Massano
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Depressive Symptoms ◽  
Deep Brain Stimulation ◽  
Medical Treatment ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Short Term ◽  
Stn Dbs ◽  
Deep Brain

<p><strong>Introduction:</strong> Deep brain stimulation (DBS) is effective in advanced Parkinson’s disease (PD), improving motor symptoms, fluctuations and quality of life. However, adverse psychiatric outcomes have been reported, albeit variably and in an unstandardized fashion. We aimed to summarize the published evidence on the outcomes of anxiety and depressive symptoms in Parkinson’s disease patients following DBS, through systematic review and meta-analysis.<br /><strong>Material and Methods:</strong> PubMed was searched until May 2012 to identify studies assessing anxiety and depressive symptoms in PD patients who underwent bilateral DBS of the subthalamic nucleus (STN) or globus pallidus internus (GPi). Random effects metaanalyses were conducted for groups of at least three studies that were homogeneous regarding the design and the instruments used.<br /><strong>Results:</strong> 63 references were selected; 98.4% provided data on depression, and 38.1% on anxiety assessment scales. Two studies did not discriminate the target; from the remaining 61 references, short-term evaluation was performed in 37 (60.7%), mid-term in 36 (59.0%) and long-term in 5 (8.2%). Data on pre to postop variation was available in 57 (93.4%) reports and 16 (26.2%) presented STNDBS versus different comparison groups: GPi-DBS (n = 4 studies, 25.0%), eligible for surgery (n = 6, 37.5%), and medical treatment (n = 7, 43.8%).<br /><strong>Discussion:</strong> Improvement of depression and anxiety is apparent after DBS, more pronounced in the short-term, an effect that seems to wane in later assessments. Concerning depression, STN-DBS shows superiority against medical treatment, but not when compared to eligible for surgery control groups. The opposite is apparent for anxiety, as results favor medical treatment over STN-DBS, and STNDBS over eligible for surgery control group. Superiority of one target over the other is not evident from the results, but data slightly favors GPi for both outcomes.<br /><strong>Conclusion:</strong> The pattern and course of depressive symptoms and anxiety following DBS in PD is not clear, although both seem to improve in the short-term, especially depression following STN-DBS. Results are highly heterogeneous. Efforts should be carried out to standardize assessment procedures across centers.<br /><strong>Keywords:</strong> Parkinson’s Disease; Deep Brain Stimulation; Anxiety; Depression; Meta-Analysis.</p>

Long-term efficacy of deep brain stimulation for essential tremor

Neurology ◽  
2019 ◽  
Vol 92 (12) ◽  
pp. e1378-e1386 ◽  
Author(s):  
Steffen Paschen ◽  
Julia Forstenpointner ◽  
Jos Becktepe ◽  
Sebastian Heinzel ◽  
Helge Hellriegel ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Rebound Effect ◽  
Short Term ◽  
Term Efficacy ◽  
Secondary Outcomes ◽  
Deep Brain

ObjectiveDeep brain stimulation (DBS) of the ventral intermediate thalamic nucleus (Vim) is established for medically refractory severe essential tremor (ET), but long-term efficacy is controversial.MethodsTwenty patients with ET with DBS had standardized video-documented examinations at baseline, in the stimulation-on condition at short term (13.1 ± 1.9 months since surgery, mean ± SEM), and in the stimulator switched on and off (stim-ON/OFF) at long term; all assessments were done between 32 and 120 months (71.9 ± 6.9 months) after implantation. The primary outcome was the Tremor Rating Scale (TRS) blindly assessed by 2 trained movement disorder neurologists. Secondary outcomes were TRS subscores A, B, and C; Archimedes spiral score; and activities of daily living score. At long-term follow-up, tremor was additionally recorded with accelerometry. The rebound effect after switching the stimulator off was assessed for 1 hour in a subgroup.ResultsTremor severity worsened considerably over time in both in the nonstimulated and stimulated conditions. Vim-DBS improved the TRS in the short term and long term significantly. The spiral score and functional measures showed similar improvements. All changes were highly significant. However, the stimulation effect was negatively correlated with time since surgery (ρ = −0.78, p < 0.001). This was also true for the secondary outcomes. Only one-third of the patients had a rebound effect terminated 60 minutes after the stimulator was switched off. Long-term worsening of the TRS was more profound during stim-ON than in the stim-OFF condition, indicating habituation to stimulation.ConclusionVim-DBS loses efficacy over the long term. Efforts are needed to improve the long-term efficacy of Vim-DBS.Classification of evidenceThis study provides Class IV evidence that for patients with medically refractory severe ET, the efficacy of Vim-DBS severely decreases over 10 years.

Deep Brain Stimulation for Dystonia

2020 ◽  
pp. 185-194
Author(s):  
Mitesh Lotia
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Gradual Onset ◽  
Primary Dystonia ◽  
Relative Scarcity ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

The past two decades have revealed substantial benefits of bilateral pallidal deep brain stimulation (DBS) in patients with medication-refractory primary dystonia. There is a growing body of evidence now describing not only short-term but also long-term benefits up to 10 years following DBS. These benefits are often sustained, requiring minimal long-term modification. Pallidal programming for dystonia may be complex owing to the gradual onset of benefits and often delayed development of side effects. There is a relative scarcity of evidence-based recommendations for standardized programming methods. This chapter reviews essential factors to consider for appropriate patient selection and discusses strategies for initial and follow-up programming. Finally, the chapter describes the potential short-term and long-term adverse effects, while considering various strategies to mitigate them.

scholarly journals Characterizing the trends in patient demographics, complications, and short-term outcomes after deep brain stimulation procedures

2021 ◽  
pp. 101466
Author(s):  
Anna R. Kimata ◽  
Stefan W. Koester ◽  
Kevin L. Ma ◽  
Joshua S. Catapano ◽  
Baltazar Zavala ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Short Term ◽  
Patient Demographics ◽  
Deep Brain

scholarly journals Inferring Deep Brain Stimulation Induced Short-term Synaptic Plasticity Using Novel Dual Optimization Algorithm

2021 ◽  
Author(s):  
Alireza Ghadimi ◽  
Leon Amadeus Steiner ◽  
Milos R Popovic ◽  
Luka Milosevic ◽  
Milad Lankarany
Keyword(s):  
Synaptic Plasticity ◽  
Steady State ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Optimization Algorithm ◽  
Model Parameters ◽  
Short Term ◽  
Model Based ◽  
Tm Model ◽  
Deep Brain

Experimental evidence in both human and animal studies demonstrated that deep brain stimulation (DBS) can induce short term synaptic plasticity (STP) in the stimulated nucleus. Given that DBS induced STP may be connected to the therapeutic effects of DBS, we sought to develop an appropriate computational predictive model that infers the dynamics of STP in response to DBS at different frequencies. Existing methods for estimating STP either model based or model free approaches require access to presynaptic spiking activity. However, in the context of DBS, extracellular stimulation (e.g. DBS) can be used to elicit presynaptic activations directly. We present a model based approach that integrates multiple individual frequencies of DBS like electrical stimulation as presynaptic spikes and infers parameters of the Tsodyks Markram (TM) model from post-synaptic currents of the stimulated nucleus. By distinguishing between the steady-state and transient responses of the TM model, we develop a novel dual optimization algorithm that infers the model parameters in two steps. First, the TM model parameters are calculated by integrating multiple frequencies of stimulation to estimate the steady state response of postsynaptic current through a closed form analytical solution. The results of this step are utilized as the initial values for the second step in which a nonderivative optimization algorithm is used to track the transient response of the postsynaptic potential across different individual frequencies of stimulation. Moreover, we apply our algorithm to empirical data recorded from acute rodent brain slices of the subthalamic nucleus (STN) during DBS like stimulation to infer dynamics of STP for inhibitory synaptic inputs.

Sign in / Sign up

Export Citation Format

Share Document