Anti-PD-1 treatment as a neurotherapy to enhance neuronal excitability, synaptic plasticity and memory
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ABSTRACTEmerging immunotherapy using anti-PD-1 antibodies have improved survival in cancer patients by immune activation. Here we show that functional PD-1 receptor is present in hippocampal CA1 neurons and loss of PD-1 or local anti-PD-1 treatment with nivolumab enhances neuronal excitability and long-term potentiation in CA1 neurons, leading to enhanced learning and memory. Our findings suggest that anti-PD-1 antibody also acts as a neurotherapy for improving memory and counteracting cognitive decline.
2021 ◽
2001 ◽
Vol 85
(1)
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pp. 399-406
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1997 ◽
Vol 331
(1)
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pp. 9-14
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2000 ◽
Vol 290
(2)
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pp. 149-153
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2000 ◽
Vol 39
(10)
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pp. 1920-1928
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2009 ◽
Vol 29
(39)
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pp. 12167-12173
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