By 1935, the Copenhagen interpretation had become the orthodoxy. Einstein needed to find a situation in which it is possible in principle to acquire knowledge of the state of a quantum system without disturbing it in any way. Working with two young theorists, Boris Podolsky and Nathan Rosen, Einstein devised an extraordinarily cunning challenge based on entangled particles. We can discover the state of one particle with certainty by making measurements on its entangled partner. All we have to assume is that the particles are local: any measurement we make on one in no way affects or disturbs the other. Through the work of David Bohm and John Bell, the challenge posed by EPR became accessible to experiment, and Bell devised a simple test for all locally realistic theories. All the experiments performed to date suggest that the standard quantum formalism is correct: in any realistic interpretation, quantum particles are non-local.