scholarly journals IFL1, a Gene Regulating Interfascicular Fiber Differentiation in Arabidopsis, Encodes a Homeodomain-Leucine Zipper Protein

1999 ◽  
Vol 11 (11) ◽  
pp. 2139-2152 ◽  
Author(s):  
Ruiqin Zhong ◽  
Zheng-Hua Ye
Keyword(s):  
Leucine Zipper ◽  
Leucine Zipper Protein ◽  
Interfascicular Fiber

IFL1, a Gene Regulating Interfascicular Fiber Differentiation in Arabidopsis, Encodes a Homeodomain-Leucine Zipper Protein

1999 ◽  
Vol 11 (11) ◽  
pp. 2139 ◽  
Author(s):  
Ruiqin Zhong ◽  
Zheng-Hua Ye
Keyword(s):  
Leucine Zipper ◽  
Leucine Zipper Protein ◽  
Interfascicular Fiber

scholarly journals IFP 35 is an interferon-induced leucine zipper protein that undergoes interferon-regulated cellular redistribution.

1994 ◽  
Vol 269 (2) ◽  
pp. 1091-1098
Author(s):  
F.C. Bange ◽  
U. Vogel ◽  
T. Flohr ◽  
M. Kiekenbeck ◽  
B. Denecke ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Leucine Zipper Protein

scholarly journals Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder

2020 ◽  
Author(s):  
Minsoo Kang ◽  
Sun Kyoung Han ◽  
Suhyun Kim ◽  
Sungyeon Park ◽  
Yerin Jo ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Metabolism ◽  
Metabolic Disorder ◽  
Leucine Zipper ◽  
Metabolic Diseases ◽  
Adenosine Monophosphate ◽  
The Body ◽  
Hepatic Gluconeogenesis ◽  
Leucine Zipper Protein

Abstract Hepatic gluconeogenesis is the central pathway for glucose generation in the body. The imbalance between glucose synthesis and uptake leads to metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Small leucine zipper protein (sLZIP) is an isoform of LZIP and it mainly functions as a transcription factor. Although sLZIP is known to regulate the transcription of genes involved in various cellular processes, the role of sLZIP in hepatic glucose metabolism is not known. In this study, we investigated the regulatory role of sLZIP in hepatic gluconeogenesis and its involvement in metabolic disorder. We found that sLZIP expression was elevated during glucose starvation, leading to the promotion of phosphoenolpyruvate carboxylase and glucose-6-phosphatase expression in hepatocytes. However, sLZIP knockdown suppressed the expression of the gluconeogenic enzymes under low glucose conditions. sLZIP also enhanced glucose production in the human liver cells and mouse primary hepatic cells. Fasting-induced cyclic adenosine monophosphate impeded sLZIP degradation. Results of glucose and pyruvate tolerance tests showed that sLZIP transgenic mice exhibited abnormal blood glucose metabolism. These findings suggest that sLZIP is a novel regulator of gluconeogenic enzyme expression and plays a role in blood glucose homeostasis during starvation.

scholarly journals Functional analysis of Met4, a yeast transcriptional activator responsive to S-adenosylmethionine.

1995 ◽  
Vol 15 (1) ◽  
pp. 208-216 ◽  
Author(s):  
L Kuras ◽  
D Thomas
Keyword(s):  
Transcriptional Activation ◽  
Leucine Zipper ◽  
Transcriptional Activator ◽  
Activation Function ◽  
Functional Domain ◽  
Distinct Region ◽  
Activation Domain ◽  
Inhibitory Region ◽  
Leucine Zipper Protein ◽  
Basic Region

Transcription of the genes necessary for sulfur amino acid biosynthesis in Saccharomyces cerevisiae is dependent on Met4, a transcriptional activator that belongs to the basic region-leucine zipper protein family. In this report, we show that one mechanism permitting the repression of the sulfur network by S-adenosylmethionine (AdoMet) involves inhibition of the transcriptional activation function of Met4. Using a wide array of deleted LexA-Met4 fusion proteins as well as various Gal4-Met4 hybrids, we identify the functional domains of Met4 and characterize their relationship. Met4 appears to contain only one activation domain, located in its N-terminal part. We demonstrate that this activation domain functions in a constitutive manner and that AdoMet responsiveness requires a distinct region of Met4. Furthermore, we show that when fused to a heterologous activation domain, this inhibitory region confers inhibition by AdoMet. Met4 contains another distinct functional domain that appears to function as an antagonist of the inhibitory region when intracellular AdoMet is low. On the basis of the presented results, a model for intramolecular regulation of Met4 is proposed.

scholarly journals Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein

2018 ◽  
Vol 46 (20) ◽  
pp. 11030-11047 ◽  
Author(s):  
C Joaquín Cáceres ◽  
Jenniffer Angulo ◽  
Fernando Lowy ◽  
Nataly Contreras ◽  
Beth Walters ◽  
...  
Keyword(s):  
Translation Initiation ◽  
Leucine Zipper ◽  
Leukemia Virus ◽  
Cell Leukemia ◽  
Basic Leucine Zipper ◽  
Cell Leukemia Virus Type ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Leucine Zipper Protein

Overexpression of the Homeobox-Leucine Zipper protein ATHB-6 improves the drought tolerance of maize (Zea mays L.)

Plant Science ◽  
2021 ◽  
pp. 111159
Author(s):  
Peng Jiao ◽  
Zhenzhong Jiang ◽  
Xiaotong Wei ◽  
Siyan Liu ◽  
Jing Qu ◽  
...  
Keyword(s):  
Zea Mays ◽  
Drought Tolerance ◽  
Leucine Zipper ◽  
Zea Mays L ◽  
Leucine Zipper Protein

scholarly journals Small Leucine Zipper Protein (sLZIP) Negatively Regulates Skeletal Muscle Differentiation via Interaction with α-Actinin-4

2013 ◽  
Vol 289 (8) ◽  
pp. 4969-4979 ◽  
Author(s):  
Hyoung-Tae An ◽  
Jeonghan Kim ◽  
Seungmin Yoo ◽  
Jesang Ko
Keyword(s):  
Skeletal Muscle ◽  
Leucine Zipper ◽  
Muscle Differentiation ◽  
Skeletal Muscle Differentiation ◽  
Leucine Zipper Protein

Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor γ activity

Life Sciences ◽  
2015 ◽  
Vol 132 ◽  
pp. 49-54 ◽  
Author(s):  
Hoon Jang ◽  
Hyoung-Joo Kim ◽  
Dong-Hwan Kim ◽  
Jae-Kyung Park ◽  
Wu-Sheng Sun ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Small Heterodimer Partner ◽  
Leucine Zipper Protein

scholarly journals Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity

2003 ◽  
Vol 48 (11) ◽  
pp. 556-563 ◽  
Author(s):  
Zheng Chen ◽  
Long Yu ◽  
Hai Wu ◽  
Jianqiang Yu ◽  
Lisha Zhang ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Inhibition Activity ◽  
Transcription Inhibition ◽  
Transcription Inhibition Activity ◽  
Leucine Zipper Protein

Engineering the Loop Region of a Homeodomain-Leucine Zipper Protein Promotes Efficient Binding to a Monomeric DNA Binding Site†

Biochemistry ◽  
2004 ◽  
Vol 43 (50) ◽  
pp. 15845-15851 ◽  
Author(s):  
Adriana E. Tron ◽  
Elina Welchen ◽  
Daniel H. Gonzalez
Keyword(s):  
Dna Binding ◽  
Binding Site ◽  
Leucine Zipper ◽  
Loop Region ◽  
Dna Binding Site ◽  
Leucine Zipper Protein
Sign in / Sign up

Export Citation Format

Share Document