Logistic planning for pharmaceutical supply chain using multi-objective optimization model

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mohammad Mahdi Ershadi ◽  
Mohamad Sajad Ershadi

Purpose Appropriate logistic planning for the pharmaceutical supply chain can significantly improve many financial and performance aspects. To this aim, a multi-objective optimization model is proposed in this paper that considers different types of pharmaceuticals, different vehicles with determining capacities and multi-period logistic planning. This model can be updated based on new information about resources and newly identified requests. Design/methodology/approach The main objective function of the proposed model in this paper is minimizing the unsatisfied prioritized requests for pharmaceuticals in the network. Besides, the total transportation activities of different types of vehicles and related costs are considered as other objectives. Therefore, these objectives are optimized hierarchically in the proposed model using the Lexicographic method. This method finds the best value for the first objective function. Then, it tries to optimize the second objective function while maintaining the optimality of the first objective function. The third objective function is optimized based on the optimality of other objective functions, as well. A non-dominated sorting genetic algorithm II-multi-objective particle swarm optimization heuristic method is designed for this aim. Findings The performances of the proposed model were analyzed in different cases and its results for different problems were shown within the framework of a case study. Besides, the sensitivity analysis of results shows the logical behavior of the proposed model against various factors. Practical implications The proposed methodology can be applied to find the best logistic plan in real situations. Originality/value In this paper, the authors have tried to use a multi-objective optimization model to guide and correct the pharmaceutical supply chain to deal with the related requests. This is important because it can help managers to improve their plans.

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mohammad Mahdi Ershadi ◽  
Hossein Shams Shemirani

PurposeProper planning for the response phase of humanitarian relief can significantly prevent many financial and human losses. To this aim, a multi-objective optimization model is proposed in this paper that considers different types of injured people, different vehicles with determining capacities and multi-period logistic planning. This model can be updated based on new information about resources and newly identified injured people.Design/methodology/approachThe main objective function of the proposed model in this paper is minimizing the unsatisfied prioritized injured people in the network. Besides, the total transportation activities of different types of vehicles are considered as another objective function. Therefore, these objectives are optimized hierarchically in the proposed model using the Lexicographic method. This method finds the best value for the first objective function. Then, it tries to optimize transportation activities as the second objective function while maintaining the optimality of the first objective function.FindingsThe performances of the proposed model were analyzed in different cases and its robust approach for different problems was shown within the framework of a case study. Besides, the sensitivity analysis of results shows the logical behavior of the proposed model against various factors.Practical implicationsThe proposed methodology can be applied to find the best response plan for all crises.Originality/valueIn this paper, we have tried to use a multi-objective optimization model to guide and correct response programs to deal with the occurred crisis. This is important because it can help emergency managers to improve their plans.


Kybernetes ◽  
2019 ◽  
Vol 49 (6) ◽  
pp. 1623-1644 ◽  
Author(s):  
Jie Jian ◽  
Milin Wang ◽  
Lvcheng Li ◽  
Jiafu Su ◽  
Tianxiang Huang

Purpose Selecting suitable and competent partners is an important prerequisite to improve the performance of collaborative product innovation (CPI). The purpose of this paper is to propose an integrated multi-criteria approach and a decision optimization model of partner selection for CPI from the perspective of knowledge collaboration. Design/methodology/approach First, the criteria for partner selection are presented, considering comprehensively the knowledge matching degree of the candidates, the knowledge collaborative performance among the candidates, and the overall expected revenue of the CPI alliance. Then, a quantitative method based on the vector space model and the synergetic matrix method is proposed to obtain a comprehensive performance of candidates. Furthermore, a multi-objective optimization model is developed to select desirable partners. Considering the model is a NP-hard problem, a non-dominated sorting genetic algorithm II is developed to solve the multi-objective optimization model of partner selection. Findings A real case is analyzed to verify the feasibility and validity of the proposed model. The findings show that the proposed model can efficiently select excellent partners with the desired comprehensive attributes for the formation of a CPI alliance. Originality/value Theoretically, a novel method and approach to partner selection for CPI alliances from a knowledge collaboration perspective is proposed in this study. In practice, this paper also provides companies with a decision support and reference for partner selection in CPI alliances establishment.


2021 ◽  
Vol 13 (15) ◽  
pp. 8279
Author(s):  
Ali Ebadi Torkayesh ◽  
Hadi Rezaei Vandchali ◽  
Erfan Babaee Tirkolaee

Healthcare Waste Management (HWM) is considered as one of the important urban decision-making problems due to its potential environmental, economic, and social risks and damages. The network of the HWM system involves important decisions such as facility locating, inventory management, and transportation management. Moreover, with growing concerns towards sustainable development objectives, HWM systems should address its environmental and social aspects as well as its economic and technical characteristics. In this regard, this paper formulates a novel multi-objective optimization model to empower companies in making optimized decisions considering the economic, environmental, and social aspects. Within the proposed model, the first objective function aims to minimize the transportation costs, processing costs, and establishment costs. The second objective function aims to minimize environmental risks and emissions related to the transportation of waste between facilities. The third objective function aims to maximize job creation opportunities. Formulating these three functions, an Improved Multi-Choice Goal Programing (IMCGP) approach is proposed to solve the multi-objective optimization model, which is then compared with the Goal Attainment Method (GAM). Finally, to show the applicability and feasibility of the proposed model, an illustrative example of healthcare waste management is analyzed, and the results are discussed.


2018 ◽  
Vol 13 (3) ◽  
pp. 605-625 ◽  
Author(s):  
Mohammad Khalilzadeh ◽  
Hadis Derikvand

Purpose Globalization of markets and pace of technological change have caused the growing importance of paying attention to supplier selection problem. Therefore, this study aims to choose the best suppliers by providing a mathematical model for the supplier selection problem considering the green factors and stochastic parameters. This paper aims to propose a multi-objective model to identify optimal suppliers for a green supply chain network under uncertainty. Design/methodology/approach The objective of this model is to select suppliers considering total cost, total quality parts and total greenhouse gas emissions. Also, uncertainty is tackled by stochastic programming, and the multi-objective model is solved as a single-objective model by the LP-metric method. Findings Twelve numerical examples are provided, and a sensitivity analysis is conducted to demonstrate the effectiveness of the developed mathematical model. Results indicate that with increasing market numbers and final product numbers, the total objective function value and run time increase. In case that decision-makers are willing to deal with uncertainty with higher reliability, they should consider whole environmental conditions as input parameters. Therefore, when the number of scenarios increases, the total objective function value increases. Besides, the trade-off between cost function and other objective functions is studied. Also, the benefit of the stochastic programming approach is proved. To show the applicability of the proposed model, different modes are defined and compared with the proposed model, and the results demonstrate that the increasing use of recyclable parts and application of the recycling strategy yield more economic savings and less costs. Originality/value This paper aims to present a more comprehensive model based on real-world conditions for the supplier selection problem in green supply chain under uncertainty. In addition to economic issue, environmental issue is considered from different aspects such as selecting the environment-friendly suppliers, purchasing from them and taking the probability of defective finished products and goods from suppliers into account.


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Reza Ehtesham Rasi ◽  
Mehdi Sohanian

Purpose The purpose of this paper is to design and optimize economic and environmental dimensions in a sustainable supply chain (SSC) network. This paper developed a mixed-integer linear programing (MILP) model to incorporate economical and environmental data for multi-objective optimization of the SSC network. Design/methodology/approach The overall objective of the present study is to use high-quality raw materials, at the same time the lowest amount of pollution emission and the highest profitability is achieved. The model in the problem is solved using two algorithms, namely, multi-objective genetic and multi-objective particle swarm. In this research, to integrate sustainable supplier selection and optimization of sustainability performance indicators in supply chain network design considering minimization of cost and time and maximization of sustainability indexes of the system. Findings The differences found between the genetic algorithms (GAs) and the MILP approaches can be explained by handling the constraints and their various logics. The solutions are contrasted with the original crisp model based on either MILP or GA, offering more robustness to the proposed approach. Practical implications The model is applied to Mega Motor company to optimize the sustainability performance of the supply chain i.e. economic (cost), social (time) and environmental (pollution of raw material). The research method has two approaches, namely, applied and mathematical modeling. Originality/value There is limited research designing and optimizing the SSC network. This study is among the first to integrate sustainable supplier selection and optimization of sustainability performance indicators in supply chain network design considering minimization of cost and time and maximization of sustainability indexes of the system.


2020 ◽  
Vol 12 (21) ◽  
pp. 8833
Author(s):  
Wei Wang ◽  
Zhentian Sun ◽  
Zhiyuan Wang ◽  
Yue Liu ◽  
Jun Chen

In order to reduce the pressure on urban road traffic, multi-modal travel is gradually replacing single-modal travel. Park and ride (P + R) and kiss and ride (K + R) are effective methods to integrate car transportation and rail transit. However, there is often an imbalance between supply and demand in existing car occupant transfer facilities, which include both P + R and K + R facilities. Therefore, we aim to conduct a research on P + R and K + R facilities’ collaborative decision. It first classifies car occupant transfer facilities into types and levels and sets the service capacity of each category. On the premise of ensuring the occupancy of parking spaces, our model aims to maximize the intercepted vehicle mileage and transfer utility and establishes an optimal decision model for car occupant transfer facilities. The model collaboratively decides the facilities in terms of location selection, layout arrangement, and overflow demand conversion to balance the supply and demand. We choose Chengdu as an example, apply the multi-objective optimization model of car occupant transfer facilities, give improved schemes, and further explore the influence of the quantity of facilities on the optimization objectives. The results show that the scheme obtained by the proposed model is significantly better than the existing scheme.


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