Seeker, whose performance severely affects the accuracy of guidance, plays an important role in guidance, just like the eyes of missiles. To design a seeker meeting the application requirements, multiple environmental conditions have to be taken in to consideration, such as the environments of production process, experiments, transportation and launching. This paper introduces a FEM method based optimization design strategy and a case study of mechanical framework optimization design for an infrared seeker as demonstration. The result of the design example seems positive and offers a proof of the effectiveness of the proposed method.