A CC IPT hybrid topology with High Misalignment Tolerant

2021 ◽  
Author(s):  
Mengzhou Sun ◽  
Jianwei Mai ◽  
Xuesong Gao ◽  
Yousu Yao ◽  
Yijie Wang ◽  
...  
Keyword(s):  
Hybrid Topology

S-Chord: Hybrid Topology Makes Chord Efficient

2005 ◽  
pp. 480-487 ◽  
Author(s):  
Liu Hui-shan ◽  
Xu Ke ◽  
Xu Ming-wei ◽  
Cui Yong
Keyword(s):  
Hybrid Topology

Affordable hybrid topology for PV and LDV's in prospering India: Case study of 48 V (P)HEV system benefits

2017 ◽  
Author(s):  
Ajith Kumaran ◽  
Ashraf Emran ◽  
Ragupathi Soundara Rajan ◽  
Vijay Sharma ◽  
Gaurav Sadekar ◽  
...  
Keyword(s):  
Hybrid Topology

scholarly journals On the interaction of an anticancer trisubstituted naphthalene diimide with G-quadruplexes of different topologies: a structural insight

2020 ◽  
Vol 48 (21) ◽  
pp. 12380-12393
Author(s):  
Chiara Platella ◽  
Marko Trajkovski ◽  
Filippo Doria ◽  
Mauro Freccero ◽  
Janez Plavec ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Dissociation Constants ◽  
Therapeutic Potential ◽  
In Vivo Studies ◽  
Binding Modes ◽  
Hybrid Topology ◽  
Naphthalene Diimide ◽  
G Quadruplex ◽  
Naphthalene Diimides

Abstract Naphthalene diimides showed significant anticancer activity in animal models, with therapeutic potential related to their ability to strongly interact with G-quadruplexes. Recently, a trifunctionalized naphthalene diimide, named NDI-5, was identified as the best analogue of a mini-library of novel naphthalene diimides for its high G-quadruplex binding affinity along with marked, selective anticancer activity, emerging as promising candidate drug for in vivo studies. Here we used NMR, dynamic light scattering, circular dichroism and fluorescence analyses to investigate the interactions of NDI-5 with G-quadruplexes featuring either parallel or hybrid topology. Interplay of different binding modes of NDI-5 to G-quadruplexes was observed for both parallel and hybrid topologies, with end-stacking always operative as the predominant binding event. While NDI-5 primarily targets the 5′-end quartet of the hybrid G-quadruplex model (m-tel24), the binding to a parallel G-quadruplex model (M2) occurs seemingly simultaneously at the 5′- and 3′-end quartets. With parallel G-quadruplex M2, NDI-5 formed stable complexes with 1:3 DNA:ligand binding stoichiometry. Conversely, when interacting with hybrid G-quadruplex m-tel24, NDI-5 showed multiple binding poses on a single G-quadruplex unit and/or formed different complexes comprising two or more G-quadruplex units. NDI-5 produced stabilizing effects on both G-quadruplexes, forming complexes with dissociation constants in the nM range.

Miniaturization of patch antenna based on hybrid topology optimization

2020 ◽  
Vol 30 (9) ◽  
Author(s):  
Shun‐Hui Zhu ◽  
Xue‐Song Yang ◽  
Jian Wang ◽  
Bing‐Zhong Wang
Keyword(s):  
Topology Optimization ◽  
Patch Antenna ◽  
Hybrid Topology
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