Strain-Insensitive Naphthalene-Diimide-Based Conjugated Polymers Through Sequential Regularity Control

Diversified structure design is applied to donor−acceptor (D−A)-type conjugated polymers (CPs) to improve their mobility−stretchability properties. Most methods that are capable of improving mechanical durability without sacrificing charge transport performance...

Enhancement in Room Temperature Ammonia Sensing Properties of Naphthalene Diimides through Core Expansion

An amperometric type sensor whose active layer is derived from a tetra core-substituted organic semiconductor, naphthalene diimide (NDI-CN4), has been evaluated for ammonia gas (3, 6, 25 and 50 ppm)...

New Near-Infrared absorbing conjugated electron donor-acceptor molecules with fused tetrathiafulvalene- naphthalene diimide framework

Molecular materials that can absorb and emit light in the near-infrared (NIR) region are getting more and more attentions in many fields. In this paper, we report the synthesis, photophysical...

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and co-crystal structures. The role of bound water molecules in the crystal structures of G-quadruplex-small molecule complexes has been analyzed in this study, focusing on the water arrangements in several G-quadruplex ligand complexes. One is the complex between the tetrasubstituted naphthalene diimide compound MM41 and a human intramolecular telomeric DNA G-quadruplex, and the others are in substituted acridine bimolecular G-quadruplex complexes. Bridging water molecules form most of the hydrogen-bond contacts between ligands and DNA in the parallel G-quadruplex structures examined here. Clusters of structured water molecules play essential roles in mediating between ligand side chain groups/chromophore core and G-quadruplex. These clusters tend to be conserved between complex and native G-quadruplex structures, suggesting that they more generally serve as platforms for ligand binding, and should be taken into account in docking and in silico studies.