In a nuclear power plant there are two major equipment with high mechanical inertia, which have a rotating shaft. These are Pumps in the Primary Heat Transport System and Turbine in the secondary system. In both cases, the shaft seizure leads to transfer of very large loads to the supports. These supports, if not designed for seizure loads may fail. If the supports fail, there is a good possibility of a missile generated and hit the safety equipment. Seizure loads in these machines have three components namely mechanical inertial load, electrical load and hydraulic load. While the electrical and hydraulic loads have a limited peak value, the inertial load depends on the seizure time. For the normal observed seizures the three have a similar order of magnitude during seizure. As the casing is overdesigned the combined load is experienced by the supports. The pump of the Primary Heat Transport System (PHTS) of a nuclear power plant is centrifugal type run by an induction motor. If the pump shaft seizes, the seizure load will be experienced by the support structure. Due to the presence of the flywheel, the total moment of inertia of the pump motor assembly is quite high. Hence the resisting torque may be higher than the support’s design torque. Besides, the electric torque will continue to be applied as the motor trip on the overload current is delayed by several seconds as the corresponding relay is a thermal relay. Seizure torque will depend on pump seizure time. Lesser the seizure time, higher would be the load on the pump supports. The turbine in the secondary system has a large inertia due to blades. In case of a seizure the generator is tripped in hundreds of milliseconds. The load experienced by turbine supports due to seizure is significantly enhanced in the first few seconds due to sustained steam supply before it is cut off. This paper discusses the estimation of the three types of loads during seizure of the shafts in the pumps and turbine. It also discusses the possible safety consequences of these loads.