Extension of Metabolic Control Theory to dynamic calcium handling in cardiac ventricular myocytes

2003 ◽  
Author(s):  
C. Smith ◽  
S. Gyorke ◽  
T. Wiesner
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Ventricular Myocytes ◽  
Calcium Handling ◽  
Metabolic Control Theory ◽  
Cardiac Ventricular Myocytes

Metabolic Control Theory

2013 ◽  
pp. 1239-1243 ◽  
Author(s):  
Emma Saavedra ◽  
Rafael Moreno-Sánchez
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Metabolic Control Theory

PRINCIPLES OF METABOLIC CONTROL THEORY

1995 ◽  
Vol 03 (01) ◽  
pp. 115-125
Author(s):  
REINHART HEINRICH
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Basic Assumption ◽  
Reaction Rates ◽  
Relaxation Processes ◽  
Metabolite Concentrations ◽  
Metabolic Control Theory ◽  
Control Coefficients

Starting from parameter independent definitions of scaled and unscaled control coefficients for fluxes and metabolite concentrations the basic assumption and equations of metabolic control theory are explained. The theory is extended for the control of relaxation processes as well as by consideration of finite perturbations of reaction rates.

scholarly journals Do deleterious mutations act synergistically? Metabolic control theory provides a partial answer.

Genetics ◽  
1993 ◽  
Vol 133 (1) ◽  
pp. 127-132 ◽  
Author(s):  
E Szathmáry
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Gene Structure ◽  
Metabolic Pathway ◽  
Equilibrium Concentration ◽  
Pool Size ◽  
Partial Answer ◽  
Deleterious Mutations ◽  
Selection For ◽  
Metabolic Control Theory

Abstract Metabolic control theory is used to derive conditions under which two deleterious mutations affecting the dynamics of a metabolic pathway act synergistically. It is found that two mutations tend to act mostly synergistically when they reduce the activity of the same enzyme. If the two mutations affect different enzymes, the conclusion depends on the way that fitness is determined by aspects of the pathway. The cases analyzed are: selection for (1) maximal flux, (2) maximal equilibrium concentration (pool size) of an intermediate, (3) optimal flux, (4) optimal pool size. The respective types of epistasis found are: (1) antagonistic, (2) partly synergistic, (3-4) synergism is likely to predominate over antagonism. This results in somewhat different predictions concerning the effect of metabolic mutations on fitness in prokaryotes and eukaryotes. The fact that bacteria are largely clonal but have often a mosaic gene structure is consistent with expectations from the model.

Dynamic Metabolic Control Theory.

1992 ◽  
Vol 665 (1 Biochemical E) ◽  
pp. 27-38 ◽  
Author(s):  
JAMES C. LIAO ◽  
JAVIER DELGADO
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Metabolic Control Theory
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