PRINCIPLES OF METABOLIC CONTROL THEORY

1995 ◽  
Vol 03 (01) ◽  
pp. 115-125
Author(s):  
REINHART HEINRICH
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Basic Assumption ◽  
Reaction Rates ◽  
Relaxation Processes ◽  
Metabolite Concentrations ◽  
Metabolic Control Theory ◽  
Control Coefficients

Starting from parameter independent definitions of scaled and unscaled control coefficients for fluxes and metabolite concentrations the basic assumption and equations of metabolic control theory are explained. The theory is extended for the control of relaxation processes as well as by consideration of finite perturbations of reaction rates.

VALUE OF CONTROL THEORY IN THE STUDY OF CELLULAR METABOLISM — BIOMEDICAL IMPLICATIONS

1995 ◽  
Vol 03 (01) ◽  
pp. 165-175 ◽  
Author(s):  
MONIQUE MALGAT ◽  
THIERRY LETELLIER ◽  
SOPHIE L. JOUAVILLE ◽  
JEAN-PIERRE MAZAT
Keyword(s):  
Cytochrome C ◽  
Control Theory ◽  
Metabolic Networks ◽  
Threshold Effect ◽  
Cytochrome C Reductase ◽  
Succinate Cytochrome C Reductase ◽  
Nadh Cytochrome ◽  
Metabolic Control Theory ◽  
Control Coefficients

We use some examples to show that Metabolic Control Theory (MTC) not only allows the determination of the controlling steps of a metabolic network with the so-called control coefficients, but also leads to better understanding of the functioning of metabolic networks. The examples are taken partly from our own work on mitochondrial myopathies, partly from the literature: — the threshold effect observed in mitochondria diseases; — the problem of the diagnosis of complex I, II or III defects by measuring the NADH-cytochrome-c-reductase or the succinate-cytochrome-c-reductase activities with illustration by some cases. The possibility of a sum of control coefficients greater than one is also considered.

Metabolic Control Theory

2013 ◽  
pp. 1239-1243 ◽  
Author(s):  
Emma Saavedra ◽  
Rafael Moreno-Sánchez
Keyword(s):  
Control Theory ◽  
Metabolic Control ◽  
Metabolic Control Theory
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